ctDNA quantification improves estimation of outcomes in patients with high-grade osteosarcoma: a translational study from the OS2006 trial

Audinot, B.; Drubay, D.; Gaspar, N.; Mohr, A.; Cordero, C.; Marec-Bérard, P.; Lervat, C.; Piperno-Neumann, S.; Jimenez, M.; Mansuy, L.; Castex, M.-P.; Revon-Riviere, G.; Marie-Cardine, A.; Berger, C.; Piguet, C.; Massau, K.; Job, B.; Moquin-Beaudry, G.; Le Deley, M.-C.; Tabone, M.-D.; Berlanga, P.; Brugières, L.; Crompton, B.D.; Marchais, A.; Abbou, S.

doi:10.1016/j.annonc.2023.12.006

ctDNA quantification improves estimation of outcomes in patients with high-grade osteosarcoma: a translational study from the OS2006 trial

PURPOSE Osteosarcoma stratification relies on clinical parameters and histological response. We developed a new personalized stratification using less invasive circulating tumor DNA (ctDNA) quantification. PATIENTS AND METHODS Plasma from patients homogeneously treated in the prospective protocol…