Cyclotron production of Ac-225 for targeted alpha therapy11Dedicated to Prof. Dr. Franz Baumgärtner on the occasion of his 75th birthday.
Abstract
The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8 MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.
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Chemical purification of the irradiated targets generates 225Ac with high isotopic purity because there are no other long-lived actinium isotopes, such as 227Ac, co-produced.
“Chemical purification of the irradiated targets generates 225Ac with high isotopic purity because there are no other long-lived actinium isotopes, such as 227Ac, co-produced (100).”
From Alpha-peptide receptor radionuclide therapy using actinium-225 labeled somatostatin receptor agonists and antagonists (2022) · cites this paper as [100]
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References 10 · Cited by 176
- Authors
- Apostolidis, C., Molinet, R., McGinley, J., Abbas, K., Möllenbeck, J., & Morgenstern, A.
- Affiliations
- Joint Research Centre (DE)
- European Commission (BE)
- Corresponding author
- Morgenstern, A.
- ORCID
- Apostolidis, C.
- Venue
- Applied Radiation and Isotopes
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 62
- Issue
- 3
- Pages
- 383-387
- ISSN
- 0969-8043 (ISSN-L)
- OpenAlex
- W2268258123
- Cited by
- 176
- References
- 10
- Citations by year
- 2026: 21 · 2025: 16 · 2024: 24 · 2023: 11 · 2022: 9 · 2021: 14 · 2020: 14 · 2019: 6 · 2018: 13 · 2017: 6 · 2016: 9 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 5
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Radiation and Isotopes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › Nuclear physics research studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Chemical Reactions and Isotopes
- Keywords
- actinium-225, cyclotron production, proton irradiation, radium-226, reaction cross sections, radiochemical separation, targeted alpha therapy, cancer radiotherapy
- MeSH terms
- Actinium, Alpha Particles, Nuclear Medicine, Protons, Radiotherapy, Radium, Cyclotrons
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