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Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides
Open accessAbstract
Eight new 9,10-anthraquinones (1–8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6–8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC–DAD–ESI–MS analysis of the extracts, the previously and newly isolated 2-methoxymethyl- and 2-ethoxymethyl-9,10-anthraquinones (4, 5, and 9–13), as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives (6–8), were shown to be solvolytic artifacts. In the in vitro assays, compound 4 was active to protect hepatocyte (WB-F344) damage.
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“However, extracting anthraquinones at temperatures above 65 °C or over 78 °C in methanol or ethanol based solvents, respectively, for prolonged periods (> 9 h) can result in the formation of artefacts, such as 2-ethoxyethyl or 2-ethoxymethyl groups [33,110].”
From Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential (2021) · cites this paper as [110]
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Research works printed but not linked: 19
- Wang, 1985, Studies on the chemical constotuents of Knoxia valerianoides Thorel ex Pitard, Acta Pharm Sin, 20, 615
- Zhou, 1994, Anthraquinones from Knoxia valerianoides, Phytochemistry, 36, 765, 10.1016/S0031-9422(00)89813-1 · DOI
- Yuan, 2005, Chemical constotuents of Knoxia valerianoides, Acta Pharm Sin, 40, 432
- Yuan, 2006, Chemical constotuents of Knoxia valerianoides, Acta Pharm Sin, 41, 735
- Yoo, 2010, Anthraquinones from the roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro, Arch Pharmacal Res, 33, 209, 10.1007/s12272-010-0204-7 · DOI
- Liu, 2011, Machilusides A and B: structurally unprecedented homocucurbitane glycosides from the stem bark of Machilus yaoshansis, Org Lett, 13, 2856, 10.1021/ol200854k · DOI
- Xiong, 2011, Lignans and neolignans from Sinocalamus affinis, and their absolute configurations, J Nat Prod, 74, 1186, 10.1021/np200117y · DOI
- Tian, 2011, Lathyrane diterpenoids from the roots of Euphorbia micractina, and their biological activities, J Nat Prod, 74, 1221, 10.1021/np2001489 · DOI
- Li, 2011, Bioactive neolignans and lignans from the bark of Machilus robusta, J Nat Prod, 74, 1444, 10.1021/np2001896 · DOI
- Lin, 2011, Two new Ar-bisabol sesquiterpenes from the stem bark of Fraxinus sielboldiana, Acta Pharm Sin B, 1, 89, 10.1016/j.apsb.2011.06.004 · DOI
- Zhao, 2011, Bioactive anthraquinones from the roots of Knoxia valerianoides, J Asia Nat Prod Res, 13, 1023, 10.1080/10286020.2011.606813 · DOI
- Zhao, 2011, Anthraquinones from the roots of Knoxia valerianoides, Chin J Chin Mater Med, 36, 2980
- Itokawa, 1983, Studies on a novel anthraquinone and its glycoside insolated from Rubia cordiforlia and R. akane, Chem Pharm Bull, 31, 2353, 10.1248/cpb.31.2353 · DOI
- Kawasaki, 1992, The mutagenic constitutents of Rubia tinctorum, Chem Pharm Bull, 40, 1504, 10.1248/cpb.40.1504 · DOI
- El-Gamal, 1995, Anthraquinones from Galium Sinaicum, Phytochemistry, 40, 245, 10.1016/0031-9422(95)00145-W · DOI
- Ling, 2002, Iridoids and anthraquinones from the Malaysian medicinal plant, Saprosma scortechinii (Rubiaceae), Chem Pharm Bull, 50, 1035, 10.1248/cpb.50.1035 · DOI
- Bowie, 1962, Colouring matters of australian plants. IX. anthraquinones from Morinda species, Aust J Chem, 15, 332, 10.1071/CH9620332 · DOI
- Cheng, 2009, Chemical constituents of the bark of Machilus wangchiana, and their biological activities, J Nat Prod, 72, 2145, 10.1021/np900504a · DOI
- Rath, 1995, Antifungal anthraquinones from Morinda lucida, Int J Pharmacogn, 33, 107, 10.3109/13880209509055208 · DOI
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Dulo, B., Phan, K., Githaiga, J., Raes, K., & De Meester, S. (2021) · Waste and Biomass Valorization · doi:10.1007/s12649-021-01443-9 · Cited by 181
“However, extracting anthraquinones at temperatures above 65 °C or over 78 °C in methanol or ethanol based solvents, respectively, for prolonged periods (> 9 h) can result in the formation of artefacts, such as 2-ethoxyethyl or 2-ethoxymethyl groups [33, 110].”
Background
Metadata
- Authors
- Zhao, F., Wang, S., Lin, S., Zhu, C., Yue, Z., Yu, Y., Liu, B., Wu, X., Yang, Y., Li, Y., & Shi, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Wang, Sujuan
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 2
- Issue
- 3
- Pages
- 260-266
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W1982607381
- Cited by
- 21
- References
- 0
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 6 · 2014: 1 · 2012: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Sciences Foundation of China (30825044, 20932007)
- National Science and Technology Project of China (2009ZX09311-004)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Phytochemistry and Bioactivity Studies
- Keywords
- 9,10-anthraquinone, natural product isolation, hepatoprotection, root extract
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