Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis

Zhao, Zhe, Li, Fangyuan, Ning, Jingwen, Peng, Ran, Shang, Junmei, Liu, Hui, Shang, Meiyu, Bao, Xiu-Qi +1 more·2021·Acta Pharmaceutica Sinica B

Cited by (137)

Items 101–137 of 137

  1. Gut bacteria composition in animal models of Parkinson’s disease: a systematic review and meta-analysis
    Joshua D. Elford, Elise Jasmijn Heesbeen, Nienke A. van der Plaats, Johan Garssen, Aletta D. Kraneveld, Lucianne Groenink, Paula Perez‐Pardo · 2026 · npj Parkinson s Disease
  2. Yinhua Gouteng decoction alleviates tic disorder symptoms by modulating neuro-inflammation in a rat model
    Mingge Hu, Yan Wei Yang, Shuxia Wang, Lirong Huang, Lifei Chen, Xinguang Zhang, Wenbo Yao, Zheng Xue · 2026 · Frontiers in Immunology
  3. Targeting TLR4 in Parkinson's disease: mechanisms and therapeutic prospects
    Shuo Dong, Jiayin Lu, Lingfeng Wu, Siyi Wang, 宫玉波, Jinglin Hu, Yang Liu, Xinhua Chen · 2026 · International Immunopharmacology
  4. The Novel Insight of Gut Microbiota from Mouse Model to Clinical Patients and the Role of NF-κB Pathway in Polycystic Ovary Syndrome
    Fansheng Kong, Panwang Huang, Jian‐Huan Chen, Yaping Ma · 2024 · Reproductive Sciences
  5. Echinatin Inhibits Oxidative Stress and Inflammatory Processes in Trophoblast Cells by Inhibiting TLR4‐MyD88‐NF‐κB Pathway in Preeclampsia
    Xiangyun Deng, Chen Hu, Yang Zhang, Fengmei Xu, Qian Zhou · 2024 · Journal of Clinical Pharmacy and Therapeutics
  6. Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway
    Fangfang Li, Yuan-Peng Zheng, Gen Li, Yang Yang, Jingwei Ma, Caixia Zang, Deng Tao, Li Li, Xiu-Qi Bao, Dan Zhang · 2025 · Journal of Asian Natural Products Research
  7. Gut-brain axis modulation in remote rehabilitation of Parkinson’s disease: reconstructing the fecal metabolome and nigral network connectivity
    Yuting Jin, Huan Wang, Jinan Song · 2025 · Frontiers in Neurology
  8. Taurine modulates gut microbiota and attenuates inflammation in a rotenone-induced mouse model of Parkinson's disease
    Yunbo Zhu, Shuo Wang, Shuang Zhao, Yu Zeng, Jing Li, Pingyue Wang, Zhijie Dou, Tianjun Wang · 2026 · NeuroToxicology
  9. ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ, НЕЙРОКОГНІТИВНІ РОЗЛАДИ І ОМЕГА-3 ПОЛІНЕНАСИЧЕНІ ЖИРНІ КИСЛОТИ (огляд лiтератури)
    Alexandr A. Serhiyenko, Вероніка Сегін, Віталій Сулима, Victoria A Serhiyenko · 2026 · PROBLEMS OF ENDOCRINE PATHOLOGY
  10. Gut microbiota: A critical regulator of oxaliplatin-induced peripheral neurotoxicity development
    Zhen Liu, TingRong Zhang, WANG Simin, HuaFang Yin, Xiaxia Shao, LingJuan Gao, XiangDong Lu · 2026 · NeuroToxicology
  11. Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson’s Disease
    Wanyu Yao, Li Liu, Jiaxin Wang, Shanshan Chen, Chaofan Zhang, Ruiyi Liao, Yiwei Wang, Kunling Ou, Lirong Jiang, Yang Yu et al. · 2026 · Cellular and Molecular Neurobiology
  12. Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis
    Mengqi Zhu, Xi Yang, Jingmin Xie, Xiaojing Shi, Jiajing Li, Yuhua Shi, Lijiang Zhang, Xinyao Tian, Yang Li, Jihong Yao et al. · 2026 · European Journal of Pharmacology
  13. Baihu Guizhi decoction alleviates inflammation in rats with acute gouty arthritis by targeting miR-17–5p to regulate the TLR4/Myd88/NF-κB signaling pathway
    GuangYu Liu, JunKai Wu, HongJie Song · 2025 · Clinics
  14. Improving Cognitive Function Through Inhibiting the Activation of Microglia by Jia Wei Kai Xin San on Alzheimer's Disease Rats
    Yang Liu, Shi-Yu Chen, Jingjing Ma, Yuqing Jiang, Feng Gu, Zheng Hong-xin · 2022 · International Journal of Pharmacology
  15. Discovery of 3-Bromoflavone Derivative D5 as a Novel TLR4-MD2 Antagonist For The Treatment of Acute Lung Injury And Sepsis
    Xu Cheng, Yijie Wang, Hao Wang, Jing Xu, Lin Wang, Shouguo Zhang, Shu‐Chen Liu, Tao Peng · 2023 · SSRN Electronic Journal
  16. Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ after multi-dose in cynomolgus monkeys
    Jiayu Li, Shuofeng Zhang, Rui Chen · 2024 · Xenobiotica
  17. Artemether Restores the Barrier Damage and Intestinal Dysbiosis to Alleviate Postoperative Cognitive Dysfunction Via Inhibiting Tlr4/Myd88/Traf6 Pathway
    Hong Yu, Siqi Chen, Xuan Li, Jingrun Lin, Zhuming Xue, Jiayi Liu, Weijie Violet Lin, Lin Sen Cao · 2024 · SSRN Electronic Journal
  18. Systemic exposure to rotenone toxicity induces gastro-inflammatory damage in mice: protective response of Zingiber officinale Roscoe extract
    Olusegun G. Adebayo, Emmanuel Uchechukwu Modo, Blessing Ogechukwu Orji, Joseph Chimezie, Iheanyichukwu Wopara, Adebimpe V. Masanwoola, Patrick Chukwuyenum Ichipi-Ifukor, Benjamin Oritsemuelebi, Kelly Iria Esezobor · 2025 · Nutrire
  19. The potential role of gut microbiota, short-chain fatty acids, and intestinal permeability in obesity: A scoping review
    Qi Tang, Yetian Liang, PeiYuan Liu, Beibei Tong, Sikai Shan, HongBo Chen, Shaomei Shang · 2025 · Interdisciplinary Nursing Research
  20. Protective effect and mechanism of synagrantol A from Euphorbia pseudomollis on LPS-induced neuroinflammation
    Qingwen Hu, Dan Zhang, Hanxuan Wang, Keyuan Chen, Fuyuan Zhang, Xin Zhang, Yi Zhun Zhu · 2025 · Journal of Ethnopharmacology
  21. D-mannose alleviates rotenone-induced PD mouse model through microbiota-gut-brain axis
    Yan Hong, Chang Ge, Jing Jin, Yifei Gao, Yujie Tang · 2026 · Scientific Reports
  22. Hydrophobic covalent organic framework as a solid-phase microextraction coating for high-throughput quantification of endocannabinoids in Parkinson’s disease rat plasma
    Di Zhao, Chunmei Zhang, Zhiyu Zhang, Z. -Y. Chen, Yanmei Shi, Kai Hu · 2026 · Journal of Chromatography B
  23. Gut Microbiota Remodeling after Fecal Microbiota Transplantation Is Associated with Reduced Inflammation and Cardiac Injury in Fluoride-Arsenic Co-Exposed Rats
    Xiaoxuan Li, Xiaolin Tian, Peng Liu, Jiyu Yuan, Penghui Liu, Xiaodong Ying, Hengyi Guo, Chenyue Ma, Di Zhao, Ruijing Xuan et al. · 2026 · Biological Trace Element Research
  24. Evodiamine alleviates MPTP-induced Parkinson’s disease in mice by regulating gut microbiota and suppressing TLR4/MyD88/NF-kB pathway
    Shuo Wang, Yunbo Zhu, Jiuxue Wang, Wei Jin, Na Li, Zhe Li, Yajun Chang, Chao Qiang Jiang, Tianjun Wang · 2026 · Scientific Reports
  25. Lycium barbarum glycopeptide alleviates diabetic retinopathy by modulating the gut microbiota and metabolites
    Yiwen Ou, Yinhua Huang, Zekai Cui, Shangli Ji, Xu Yang, Rangsheng Mei, Zhexiong Yu, Kwok‐Fai So, Jiansu Chen, Shibo Tang et al. · 2026 · Neural Regeneration Research
  26. Neuroprotective effects of a biopeptidomimetic on an in vitro model
    Olga Babich, Сергей Леонидович Тихонов, Irina Mikhailovna Chernukha, Станислав Алексеевич Сухих, Наталья Валерьевна Тихонова, Евгений Борисович Сысуев · 2026 · Food systems
  27. PB2 alleviates diabetic nephropathy: Intervene gut-flora-dependent metabolite TMAO promote DN-associated inflammatory responses through ferroptosis, ER stress–autophagy axis, and macrophage polarization
    Qingqing Zhang, Ziheng Zhang, Nannan Song, Chongzheng Pang, Fanglong Hu, Jianpeng Li, Can Liu, Aiya Zhao, Jinting Chen, Baohua Chen et al. · 2026 · Journal of Pharmaceutical Analysis
  28. Muribaculaceae regulate β-muricholic acid to target S1PR2 signaling and reduce neurological injury in intracerebral hemorrhage
    Song Liu, Yi Lv · 2026 · Experimental Neurology
  29. Zexieyin formula ameliorates high-fat diet-induced cognitive impairment via pericyte-associated LRP1 modulating CypA/NF-κB/MMP-9 pathway
    Shihan Zhou, XinYi Chen, MeiLing Ni, Wenwen Chang, Rumin Huang, Yanqing Wang, Xiangrui Zhang, Hailou Zhang, Haoxin Wu, Yan Sun · 2026 · Phytomedicine
  30. Protective Effects of Cubebin on Neuroinflammation, Neurotransmitter Depletion, Mitochondrial Dysfunction, and Motor Disability in Parkinsonian Rats
    Omar Awad Alsaidan, Ameeduzzafar Zafar, Naveed Ahmad, Nadeem Sayyed, Sami Ibrahim Alzarea · 2026 · Journal of Disability Research
  31. The inhibition of lactate/Gpr81 signalling driven by moderate-intensity continuous training protects against osteoarthritis
    Peng Sun, Yilan Guo, Aochuan Xue, Jingting Ni, Yichen Ren, Yan Sun, Xingyu Qian, Xiaoliu Li, Yu You, Ying Zhao et al. · 2026 · Experimental & Molecular Medicine
  32. Effects of maternal supplementation with fatty acid-balanced oil on the performance of sows and intestinal barrier function of offspring
    Huiling Zhu, Yuhui Tang, Kun Qin, Mengke Yan, Yu Cao, Jihua Wang, Xiao Xu, Shaokui Chen, Kan Xiao, Yulan Liu · 2026 · Animal nutrition
  33. In Vivo Evaluation of the Efficacy, Biosafety, and Bioavailability of Potential NBC Probiotic Strains
    Elvan Anadol, Ateş Kara, Hasan Tezer, Şaban Cem Sezer, Zeynep Yığman, Deniz Billur, Beyza Aydoğan Kara, Sibel Söylemez, Sinem Yücel Aytekin, Mustafa Arslan · 2026 · Research Square
  34. Near-infrared photocatalytic oral microalgae-carbon nitride-based nanozyme ameliorate Parkinson's disease via suppressing gut microbiota-indole-3-lactic acid-brain axis-mediated neuroinflammation
    Xiao-Ling Zhang, Yue Yang, Yan Zhang, Yanchao Liu, Meng-Zhu Zhou, Chao Chen, Yi-Tong Tao, Qitao Zhang, Mingxuan Liu · 2026 · Biomaterials
  35. Microbiota-regulated TCDCA associates with Parkinson’s disease severity and promotes BBB dysfunction through VSMC TGR5 signaling in mice
    Zhe Zhao, LIU Yixuan, Wen Ma, Gaofei Hu, Jincen Hao, Bai Chaobo, Jing Chen, Qi Zhang, Huanhuan Cao, Xiaoyi Liu et al. · 2026 · Cell Reports Medicine
  36. Research Progress on the Neuroprotective Effects of Intranasal Insulin via Modulation of Inflammatory Signaling Pathways
    Dai Qing · 2026 · Advances in Clinical Medicine
  37. Small Molecules Targeting TrkB/BDNF for Neurodegenerative Disease Therapeutic Discovery
    Ramu Venkatesan, Megan P. Paustian, Princess Simeon, Paul C. Trippier · 2026 · ACS Chemical Neuroscience