The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications
Open accessAbstract
Pharmaceutical cocrystals are multicomponent systems in which at least one component is an active pharmaceutical ingredient and the others are pharmaceutically acceptable ingredients. Cocrystallization of a drug substance with a coformer is a promising and emerging approach to improve the performance of pharmaceuticals, such as solubility, dissolution profile, pharmacokinetics and stability. This review article presents a comprehensive overview of pharmaceutical cocrystals, including preparation methods, physicochemical properties, and applications. Furthermore, some examples of drug cocrystals are highlighted to illustrate the effect of crystal structures on the various aspects of active pharmaceutical ingredients, such as physical stability, chemical stability, mechanical properties, optical properties, bioavailability, sustained release and therapeutic effect. This review will provide guidance for more efficient design and manufacture of pharmaceutical cocrystals with desired physicochemical properties and applications.
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Cites
Insoluble drug delivery strategies: review of recent advances and business prospects
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Pharmaceutical cocrystals: along the path to improved medicines
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Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications
Karimi-Jafari, M., Padrela, L., Walker, G. M., & Croker, D. M. (2018) · Crystal Growth & Design · doi:10.1021/acs.cgd.8b00933 · Cited by 667
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Cited by
Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13
Metadata
- Authors
- Guo, M., Sun, X., Chen, J., & Cai, T.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 11
- Issue
- 8
- Pages
- 2537-2564
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W3137880689
- Cited by
- 386
- References
- 69
- FWCI
- 27.70
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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