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Cited by 428

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Green synthesis: In-vitro anticancer activity of copper oxide nanoparticles against human cervical carcinoma cells

Open access
Nagajyothi, P.C., Muthuraman, P., Sreekanth, T.V.M., Kim, Doo Hwan, Shim, Jaesool·2017·Arabian Journal of Chemistry

Abstract

Copper oxide nanoparticles (CuO NPs) were synthesized by a green route using an aqueous black bean extract and characterized by XRD, FT-IR, XPS, Raman spectroscopy, DLS, TEM, SAED, SEM, and EDX. The synthesized CuO NPs were spherical in shape, and the XRD results show the average size of the NPs was ∼26.6 nm. The cytotoxic effect of the CuO NPs was determined by sulforhodamine-B assay. Mitochondria-derived reactive oxygen species (ROS) were increased and initiated lipid peroxidation of the liposomal membrane, which regulates several signaling pathways and influences the cytokinetic movements of cells. Mitochondrial fragmentation disruption assay confirmed the alteration in the mitochondrial structure after incubation with nanoparticles. In addition, clonogenic assay confirmed the inability of NPs incubated cancer cells to proliferate well. Our experimental results show that the CuO NPs can induce apoptosis and suppress the proliferation of HeLa cells.

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Metadata

Authors
Nagajyothi, P. C., Muthuraman, P., Sreekanth, T. V. M., Kim, D. H., & Shim, J.
Venue
Arabian Journal of Chemistry
Published
2017-02
Volume
10
Issue
2
Pages
215-225
ISSN
1878-5352 (ISSN-L)
OpenAlex
W2277763500
Cited by
428
References
45
FWCI
10.33
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Green synthesis: In-vitro anticancer activity of copper oxide nanoparticles against human cervical carcinoma cells. https://app.cochat.ai/papers/10.1016/j.arabjc.2016.01.011
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Nagajyothi, P. C., Muthuraman, P., Sreekanth, T. V. M., Kim, D. H., & Shim, J. (2017). Green synthesis: In-vitro anticancer activity of copper oxide nanoparticles against human cervical carcinoma cells. Arabian Journal of Chemistry. https://doi.org/10.1016/j.arabjc.2016.01.011

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