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Cited by 22Bone Tissue Engineering MaterialsPeriodontal Regeneration and TreatmentsDental Implant Techniques and Outcomes

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Basic fibroblast growth factor up-regulates the expression of vascular endothelial growth factor during healing of allogeneic bone graft

Rabie, A. Bakr M., Lu, Mei·2004·Archives of Oral Biology
DOI 10.1016/j.archoralbio.2004.05.012
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Abstract

Recently we reported that basic fibroblast growth factor (bFGF) improved the healing of allogeneic bone grafts. However, the mechanism of action of the bFGF was not known. Therefore, the present study was designed to identify the expression pattern of vascular endothelial growth factor (VEGF) in the presence of bFGF reconstituted in demineralized intramembranous bone matrix (DBMIM) during the healing of allogeneic bone grafts. Eighteen critical size (15 mm x 10 mm) defects were created on rabbit mandibles bilaterally. Three groups of six defects each were grafted with allogeneic bone alone, allogeneic bone and DBMIM, and allogeneic bone and bFGF reconstituted in DBMIM. Three weeks later, the defects were retrieved for immunohistochemistry and in situ hybridization for VEGF. The percentage of positive staining area was quantified by using image analyzer. The increase (517%) in the expression of VEGF mRNA was accompanied by an increase (492%) of immunoreactive VEGF protein in allogeneic bone graft augmented by bFGF reconstituted in DBMIM. A close correlation existed between levels of VEGF production and the amount of newly formed bone. The results show that bFGF reconstituted in DBMIM markedly up-regulated the expression of VEGF in the grafted area. Basic FGF augments the healing of allogeneic bone grafts by enhancing vascularization through the up-regulation of VEGF.

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Metadata

Authors
Rabie, A. B. M., & Lu, M.
Affiliations
Prince Philip Dental Hospital (CN)
Corresponding author
Rabie, A. Bakr M.
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2004-12
Volume
49
Issue
12
Pages
1025-1033
ISSN
0003-9969 (ISSN-L)
DOI
10.1016/j.archoralbio.2004.05.012
OpenAlex
W2049557883
Cited by
22
References
1
Citations by year
2023: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Oral Biology (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • University of Melbourne
  • University of Hong Kong
  • Chinese University of Hong Kong
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
Keywords
basic fibroblast growth factor, vascular endothelial growth factor, bone allografts, bone regeneration, demineralized bone matrix, critical-size bone defect, bone vascularization, VEGF mRNA expression, rabbit mandible
MeSH terms
Animals, Bone and Bones, Immunohistochemistry, Rabbits, RNA, Messenger, Wound Healing, Up-Regulation, Bone Transplantation, Fibroblast Growth Factor 2, In Situ Hybridization, Neovascularization, Physiologic, Vascular Endothelial Growth Factors

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