Sexual dimorphism of murine masticatory muscle function
Open accessAbstract
Objective To determine if gender distinctions of force generating capacity existed in murine masticatory muscles.Design In order to investigate the effect of sex on force generating capacity in this muscle group, an isolated muscle preparation was developed utilising the murine anterior deep masseter. Age-matched male and female mice were utilized to assess function, muscle fibre type and size in this muscle.Results Maximum isometric force production was not different between age-matched male and female mice. However, the rate of force generation and relaxation was slower in female masseter muscles. Assessment of fibre type distribution by immunohistochemistry revealed a three-fold decrease in the proportion of myosin heavy chain 2b positive fibres in female masseters, which correlated with the differences in contraction kinetics.Conclusions These results provide evidence that masticatory muscle strength in mice is not affected by sex, but there are significant distinctions in kinetics associated with force production between males and females.
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Analysis of tetanic force in the mouse masseter shows no significant differences between the sexes on force production.
“Analysis of tetanic force in the mouse masseter shows no significant differences between the sexes on force production (22).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [22]
During a tetanic force protocol, the maximal rate of force generation is significantly higher in males than in females (516 vs. 382 g/s).
“However, the same study reveals that, during a tetanic force protocol, the maximal rate of force generation is significantly higher in males than in females (516 vs. 382 g/s).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [22]
The rate of relaxation is significantly faster in the male masseter during a tetanus compared with the female masseter (41 vs. 48 ms).
“Additionally, the rate of relaxation is significantly faster in the male masseter during a tetanus compared with the female masseter (41 vs. 48 ms) (22).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [22]
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References 33 · Cited by 19
- Authors
- Daniels, D. W., Tian, Z., & Barton, E. R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Barton, Elisabeth R.
- ORCID
- Barton, Elisabeth R.
- Venue
- Archives of Oral Biology
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 53
- Issue
- 2
- Pages
- 187-192
- ISSN
- 0003-9969 (ISSN-L)
- PMC
- PMC2262833
- OpenAlex
- W1995909089
- Cited by
- 19
- References
- 33
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 3 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Oral Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (U54AR052646, R01AR057363)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- sexual dimorphism, masticatory muscles, masseter muscle, isometric force production, contraction kinetics, relaxation rate, muscle fiber type distribution, muscle fiber size
- MeSH terms
- Animals, Biomechanical Phenomena, Bite Force, Female, Isometric Contraction, Male, Masticatory Muscles, Sex Characteristics, Muscle Fibers, Skeletal, Mice
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