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Calcium mitigates fluoride-induced kallikrein 4 inhibition via PERK/eIF2α/ATF4/CHOP endoplasmic reticulum stress pathway in ameloblast-lineage cells

Liu, Xiaojing, Huang, Ruizhe, Gao, Yuguang, Gao, Meili, Ruan, Jianping, Gao, Jianghong·2021·Archives of Oral Biology
DOI 10.1016/j.archoralbio.2021.105093
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Abstract

Objectives The present study aimed to investigated the effect and mechanism of Ca 2+ treatment on fluoride in ameloblast-lineage cells (ALCs). Materials and methods The effects of fluoride and different Ca 2+ levels treatment on the proliferative activity, cell apoptosis, cell cycle, intracellular free Ca 2+ , were firstly determined. Kallikrein 4 (KLK4), glucose-responsive protein 78 (GRP78), Protein kinase R -like endoplasmic reticulum kinase (PERK), the α subunit of eukaryotic initiation factor 2 (eIF2α), activating transcription factor 4 (ATF4), CCAAT enhancer-binding protein homologous protein (CHOP), were investigated in ALCs. Results The proliferative activity was obviously inhibited under concentrations of single fluoride high than 1 mM, and indicated highest proliferation at single 2.5 mM Ca 2+ concentration in ALC cells. In addition, we found that single fluoride markedly induced intracellular free Ca 2+ increasing, G2/M phase arrest, apoptosis. GRP78 and endoplasmic reticulum stress pathway of PERK/eIF2α/ATF4/CHOP were significantly increased, while the proliferation and KLK4 were markedly reduced in ALCs. Ca 2+ additional treatment can obviously reverse the effect of fluoride-induced apoptosis and inhibition of KLK4. The effect of GRP78 and endoplasmic reticulum stress pathway of PERK/eIF2α/ATF4/CHOP were also alleviated under Ca 2+ additional treatment in ALCs. More important, the results of 2.5 mmol/L Ca 2+ treatment on the proliferation, cell cycle and apoptosi…

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Metadata

Authors
Liu, X., Huang, R., Gao, Y., Gao, M., Ruan, J., & Gao, J.
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2021-05
Volume
125
Pages
105093
ISSN
0003-9969
DOI
10.1016/j.archoralbio.2021.105093
Cited by
17
References
0
Language
en
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