Regulatory RNA-binding proteins in senescence
Abstract
The expression of senescence-associated genes, which governs the progression and the maintenance of senescence, is regulated at multiple levels. Apart from the transcriptional mechanisms that control cellular senescence, studies over the past decade have revealed that post-transcriptional gene regulation, especially through changes in mRNA turnover and translation, critically influences protein expression patterns in the senescent cell. Among the post-transcriptional regulatory factors, RNA-binding proteins (RBPs) are particularly influential in the establishment of senescence-associated protein profiles. In this review, I discuss the current knowledge of the role of RBPs in cellular senescence and the molecular mechanisms that regulate their function.
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Post-transcriptional regulatory pathways contribute to control senescence through the action of RBPs and noncoding RNAs, particularly specific miRNAs.
“Post-transcriptional regulatory pathways also contribute to control senescence through the action of mRNA-binding proteins (RBPs) and noncoding RNAs, particularly specific microRNAs (miRNAs), the levels of which help to mediate the senescence state [179,180].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [180]
Cites
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Transcriptional regulation of cellular senescence
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Mechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works
- Authors
- Wang, W.
- Affiliations
- Peking University (CN)
- Corresponding author
- Wang, Wengong
- ORCID
- Wang, Wengong
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 11
- Issue
- 4
- Pages
- 485-490
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2071980615
- Cited by
- 27
- References
- 5
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- cellular senescence, RNA-binding proteins, post-transcriptional regulation, mRNA turnover, translational regulation, senescence-associated gene expression
- MeSH terms
- Animals, Humans, RNA Processing, Post-Transcriptional, RNA, Messenger, Protein Biosynthesis, RNA-Binding Proteins, Cellular Senescence
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