Dietary restriction and lifespan: lessons from invertebrate models
Open accessAbstract
Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.
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Signal modulations including mRNA translation, transcription, autophagy, and mitochondrial function have been shown to mediate extended lifespan.
“These signal modulations, including mRNA translation, transcription, autophagy, and mitochondrial function, have been shown to mediate extended lifespan [186].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [186]
The round worm Caenorhabditis elegans is used to investigate metabolic pathways and has been instrumental in elucidating key genetic regulators of metabolism in relation to lifespan.
“The round worm Caenorhabditis elegans, for instance, is used to investigate metabolic pathways and has been instrumental in elucidating key genetic regulators of metabolism in relation to lifespan (36, 293, 294).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [36]
Dietary restrictions increase lifespan and healthspan in all animal models of aging (yeast, C. elegans, Drosophila, mouse).
“Dietary restrictions have been shown to increase lifespan and healthspan in all animal models of aging (e.g., yeast, C. elegans, Drosophila, mouse) [239,289,290,291].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [291]
Nutrient-sensing mTOR and insulin/IGF1 pathways mediate the effect of dietary restriction on aging.
“It is evident that the nutrient-sensing mTOR and the insulin/IGF1 pathways mediate the effect of dietary restriction on aging [149,291].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [291]
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References 187 · Cited by 340
- Authors
- Kapahi, P., Kaeberlein, M., & Hansen, M.
- Affiliations
- Buck Institute for Research on Aging (US)
- University of Washington (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Hansen, Malene
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 39
- Pages
- 3-14
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC5476520
- OpenAlex
- W2564232696
- Cited by
- 340
- References
- 187
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 33 · 2023: 40 · 2022: 44 · 2021: 62 · 2020: 38 · 2019: 39 · 2018: 27 · 2017: 13
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01AG038688, AG045835, AG038518, AG031108, AG005136, AG013280, AG038664, AG039756)
- AFAR
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- dietary restriction, lifespan extension, invertebrate models, mTOR, insulin/IGF-1 signaling, sirtuins, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, aging
- MeSH terms
- Animals, Drosophila, Drosophila melanogaster, Insulin, Insulin-Like Growth Factor I, Longevity, Recombinant Proteins, Saccharomyces cerevisiae, Signal Transduction, Caenorhabditis elegans, Models, Animal, Caloric Restriction, Sirtuins, TOR Serine-Threonine Kinases
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