Circadian rhythms, time-restricted feeding, and healthy aging
Open accessAbstract
Circadian rhythms optimize physiology and health by temporally coordinating cellular function, tissue function, and behavior. These endogenous rhythms dampen with age and thus compromise temporal coordination. Feeding-fasting patterns are an external cue that profoundly influence the robustness of daily biological rhythms. Erratic eating patterns can disrupt the temporal coordination of metabolism and physiology leading to chronic diseases that are also characteristic of aging. However, sustaining a robust feeding-fasting cycle, even without altering nutrition quality or quantity, can prevent or reverse these chronic diseases in experimental models. In humans, epidemiological studies have shown erratic eating patterns increase the risk of disease, whereas sustained feeding-fasting cycles, or prolonged overnight fasting, is correlated with protection from breast cancer. Therefore, optimizing the timing of external cues with defined eating patterns can sustain a robust circadian clock, which may prevent disease and improve prognosis.
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The molecular clock at the cellular and tissue levels can have significant effects on physiology.
“This demonstrates how the molecular clock at the cellular and tissue levels can have significant effects on physiology [249].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [249]
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References 130 · Cited by 330
Research works printed but not linked: 2
- Korte M Carrolltt P Wolf E Brem G Thoenent H Bonhoeffer T Brain-Derived Neurotrophic 1995 92 8856 8860 PMC41066 7568031
- Roh JH Huang Y Bero AW Kasten T Stewart FR Bateman RJ Holtzman DM Sleep-wake cycle and diurnal fluctuation of amyloid-β as biomarkers of brain amyloid pathology Sci. Transl. Med 2012 4 1 20 PMC3654377 22956200
- Authors
- Manoogian, E. N. C., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Panda, Satchidananda
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 39
- Pages
- 59-67
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC5814245
- OpenAlex
- W2562847852
- Cited by
- 330
- References
- 130
- Citations by year
- 2026: 36 · 2025: 40 · 2024: 32 · 2023: 49 · 2022: 41 · 2021: 47 · 2020: 42 · 2019: 20 · 2018: 16 · 2017: 7
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY016807)
- National Cancer Institute (P30CA014195)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- circadian rhythm, time-restricted feeding, healthy aging, feeding-fasting cycle, chronic disease prevention, breast cancer
- MeSH terms
- Healthy Aging, Aging, Animals, Circadian Rhythm, Energy Metabolism, Fasting, Feeding Behavior, Humans
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