Corticosteroids and local anesthetics decrease positive effects of platelet-rich plasma: an in vitro study on human tendon cells

Carofino, Bradley; Chowaniec, David M.; McCarthy, Mary Beth; Bradley, James P.; Delaronde, Steve; Beitzel, Knut; Cote, Mark P.; Arciero, Robert A.; Mazzocca, Augustus D.

doi:10.1016/j.arthro.2011.09.013

Corticosteroids and local anesthetics decrease positive effects of platelet-rich plasma: an in vitro study on human tendon cells

Purpose To determine the effects of mixing anesthetics or corticosteroids with platelet-rich plasma (PRP) on human tenocytes in vitro. Methods Two separate protocols (double spin and single spin) were used to obtain homologous PRP from the blood of 8 healthy volunteers. Discarded tendon acquired …