Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice

Pedersen, Tanja X.; Bro, Susanne; Andersen, Mikkel H.; Etzerodt, Michael; Jauhiainen, Matti; Moestrup, Søren; Nielsen, Lars B.

doi:10.1016/j.atherosclerosis.2008.04.041

Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice

Objective Uremia markedly increases the risk of atherosclerosis. Thus, effective anti-atherogenic treatments are needed for uremic patients. This study examined effects of non-lipidated recombinant human apoA-I (h-apoA-I) and a recombinant trimeric apoA-I molecule (TripA-I) on lipid metabolism an…