Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages

Adorni, Maria Pia; Cipollari, Eleonora; Favari, Elda; Zanotti, Ilaria; Zimetti, Francesca; Corsini, Alberto; Ricci, Chiara; Bernini, Franco; Ferri, Nicola

doi:10.1016/j.atherosclerosis.2016.11.019

Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages

Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) may have extra-hepatic effects on cholesterol homeostasis of vascular macrophages. In this study, we aimed to investigate PCSK9 role on the anti-atherogenic process of ATP binding cassette transporter A1 (Abca1)-mediated ch…