Real world efficacy of bempedoic acid in statin-intolerant patients with high cardiovascular risk
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In a small prospective study (n=15) in high cardiovascular risk patients with statin intolerance, after 3 months only 8 patients remained on bempedoic acid.
“After 3 months, only 8 patients remained on bempedoic acid; these patients achieved a 32.3% LDL-C reduction (baseline LDL-C = 179.0 mg/dL) [35].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [35]
The paper’s Abstract reports that 10 of 15 patients were still taking bempedoic acid at approximately three months, not eight. Eight was the number of continuing patients whose LDL cholesterol fell; that subgroup had a mean reduction of 32.3%. (LLM, conf=0.91)
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Experimental — accuracy not yet measuredLDL-C reductions with bempedoic acid in statin-intolerant patients ranged from 22% to 38%.
“Consistent effects were also seen when bempedoic acid was added to statins (15% to 39%) [25,30,32,38,39,44], and when used in statin intolerant patients (22% to 38%) [24,29,34,35,37,40,41], despite the latter group having higher baseline LDL-C.”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [35]
The paper’s Abstract reports a mean LDL-cholesterol reduction of 32.3% in eight statin-intolerant patients whose LDL cholesterol fell, which is within the cited range. It does not report a 22%–38% range; its mean also excludes patients who had no reduction. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThose 8 patients achieved a 32.3% LDL-C reduction at 3 months.
“these patients achieved a 32.3% LDL-C reduction (baseline LDL-C = 179.0 mg/dL) [35].”
From Systematic literature review on the real-world effectiveness and safety of bempedoic acid (2026) · cites this paper as [35]
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Systematic literature review on the real-world effectiveness and safety of bempedoic acid
Cicero, A. F. G., Cannon, C. P., Gautam, R., Anwar, S., Ghatak, A., Sarnes, E., Powell, H. A., Chhabra, R., & Jawla, S. (2026) · Atherosclerosis Plus · doi:10.1016/j.athplu.2026.100562 · Cited by 1 · see citing works
“[24,29,34,35,37,40,41], despite the latter group having higher baseline LDL-C.”
Influential
- Authors
- Mccarron, E. P., Hamilton, P., & Roberts, B. V.
- Affiliations
- Royal Victoria Hospital (GB)
- ORCID
- Hamilton, P.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 355
- Pages
- 220
- ISSN
- 0021-9150 (ISSN-L)
- OpenAlex
- W4293579360
- Cited by
- 3
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Atherosclerosis (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- bempedoic acid, statin intolerance, ATP-citrate lyase inhibitor, dyslipidemia, high cardiovascular risk, real-world effectiveness, tolerability, routine clinical practice
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