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Lung Transplantation and Coronary Artery Disease
Abstract
Background Coronary artery disease (CAD) remains a relative contraindication to lung transplantation. We have offered lung transplantation and coronary revascularization to selected patients with discrete CAD and preserved left ventricular function. The purpose of this report is the following: (1) to examine the short-term and medium-term outcome of patients after coronary revascularization and lung transplantation; and (2) to compare the short-term and medium-term outcome of this cohort to a matched group of lung transplant recipients without CAD. Methods From January 2000 to March 2010, 27 patients with CAD underwent coronary revascularization and lung transplantation. The control group was matched based on age, diagnosis, lung allocation score, and type of procedure. Results Lung transplant recipients with CAD and the control group had similar incidence of primary graft dysfunction (grade III). The duration of mechanical ventilation, intensive care unit stay, and hospital stay were the same. At a mean follow-up of 3 years, the incidence of composite adverse cardiac events was similar in the 2 groups. Conclusions Lung transplant recipients with CAD and the control group also had similar medium-term survival. Lung transplantation can be considered in patients with preexistent CAD with acceptable early and medium-term outcomes.
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There was no significant difference in the survival rate of patients with mild to moderate CAD or who underwent coronary intervention before surgery.
“there was no significant difference in the survival rate of patients with mild to moderate CAD or who underwent coronary intervention before surgery”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [17]
Peripheral vascular disease is not considered an absolute contraindication for lung transplantation.
“PVD is not considered an absolute contraindication”
From Indications for Lung Transplantation and Patient Selection (2022) · cites this paper as [17]
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No references could be resolved yet.
Research works printed but not linked: 17
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Cited by
Sorted by citations
Chaikriangkrai, K., Jyothula, S., Jhun, H. Y., Estep, J., Loebe, M., Scheinin, S., & Torre-Amione, G. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.08.009 · Cited by 33
McKellar, S. H., Bowen, M. E., Baird, B. C., Raman, S., Cahill, B. C., & Selzman, C. H. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.05.029 · Cited by 31
How important is coronary artery disease when considering lung transplant candidates?
Koprivanac, M., Budev, M. M., Yun, J. J., Kelava, M., Pettersson, G. B., McCurry, K. R., Johnston, D. R., Mangi, A. A., Houghtaling, P. L., Blackstone, E. H., et al. (2016) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2016.03.011 · Cited by 30
Halloran, K., Hirji, A., Li, D., Jackson, K., Kapasi, A., Meyer, S., Mullen, J., Lien, D., & Weinkauf, J. (2019) · Transplantation · doi:10.1097/tp.0000000000002609 · Cited by 21
Lung transplant patients with coronary artery disease rarely die of cardiac causes
Makey, I. A., Sui, J. W., Huynh, C., Das, N. A., Thomas, M., & Johnson, S. (2018) · Clinical Transplantation · doi:10.1111/ctr.13354 · Cited by 18
Indications for Lung Transplantation and Patient Selection
Son, J., & Shin, C. (2022) · Journal of Chest Surgery · doi:10.5090/jcs.22.057 · Cited by 10
“As patients with PVD are more likely to have concomitant vascular disease, which can be a problem, various preoperative evaluations are necessary, and a cautious approach must be taken [17-20].”
Background
Metadata
- Authors
- Sherman, W., Rabkin, D. G., Ross, D., Saggar, R., Lynch, J. P., Belperio, J., Saggar, R., Hamilton, M., & Ardehali, A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Ardehali, Abbas
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 92
- Issue
- 1
- Pages
- 303-308
- ISSN
- 0003-4975 (ISSN-L)
- OpenAlex
- W2043988266
- Cited by
- 40
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Annals of Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Keywords
- lung transplantation, coronary artery disease, coronary revascularization, primary graft dysfunction, post-transplant survival, adverse cardiac events, left ventricular function, transplant contraindications
- MeSH terms
- Aged, Coronary Artery Bypass, Cause of Death, Combined Modality Therapy, Coronary Artery Disease, Female, Follow-Up Studies, Graft Rejection, Graft Survival, Humans, Male, Middle Aged, Postoperative Complications, Prognosis, Retrospective Studies, Survival Analysis, Case-Control Studies, Lung Transplantation, Hospital Mortality, Lung Diseases, Interstitial, Risk Assessment, Patient Selection, Pulmonary Disease, Chronic Obstructive, Kaplan-Meier Estimate
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