The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Blood Transfusion and Infection After Cardiac Surgery
Open accessAbstract
Cardiac surgery is the largest consumer of blood products in medicine; although believed life saving, transfusion carries substantial adverse risks. This study characterizes the relationship between transfusion and risk of major infection after cardiac surgery. 5,158 adults were prospectively enrolled to assess infections after cardiac surgery. The most common procedures were isolated coronary artery bypass grafting (31%) and isolated valve surgery (30%); 19% were reoperations. Infections were adjudicated by independent infectious disease experts. Multivariable Cox modeling was used to assess the independent effect of blood and platelet transfusions on major infections within 60±5 days of surgery. Red blood cells (RBCs) and platelets were transfused in 48% and 31% of patients, respectively. Each RBC unit transfused was associated with a 29% increase in crude risk of major infection (P<0.001). Among RBC recipients, the most common infections were pneumonia (3.6%) and bloodstream infections (2%). Risk factors for infection included postoperative RBC units transfused, longer duration of surgery, and transplant or ventricular assist device implantation, in addition to chronic obstructive pulmonary disease, heart failure, and elevated preoperative creatinine. Platelet transfusion decreased the risk of infection (P=.02). Greater attention to management practices that limit RBC use, including cell salvage, small priming volumes, vacuum-assisted venous return with rapid autologous priming, and ultrafiltration, and pre- and intraoperative measures to elevate hematocrit could potentially reduce occurrence of major postoperative infections.
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Cites
Horan, T. C., Andrus, M., & Dudeck, M. A. (2008) · American Journal of Infection Control · doi:10.1016/j.ajic.2008.03.002 · Cited by 6,626
Murphy, G. J., Reeves, B. C., Rogers, C. A., Rizvi, S. I. A., Culliford, L., & Angelini, G. D. (2007) · Circulation · doi:10.1161/circulationaha.107.698977 · Cited by 1,371 · cited 1×
“Although an increase in infections may itself explain the relation between RBC transfusion and prolonged postoperative length of stay and increased mortality, it also has been demonstrated that the number of transfusions given during and after cardiac surgery appears to be associated with not only increased early mort…”
Duration of Red-Cell Storage and Complications after Cardiac Surgery
Koch, C. G., Li, L., Sessler, D. I., Figueroa, P., Hoeltge, G. A., Mihaljevic, T., & Blackstone, E. H. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070403 · Cited by 1,363
Self-citationFerraris, V. A., Brown, J. R., Despotis, G. J., Hammon, J. W., Reece, T. B., Saha, S. P., Song, H. K., Clough, E. R., Shore-Lesserson, L. J., Goodnough, L. T., et al. (2011) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2010.11.078 · Cited by 1,289
Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial
Hajjar, L. A., Vincent, J.-L., Galas, F. R. B. G., Nakamura, R. E., Silva, C. M. P., Santos, M. H., Fukushima, J., Filho, R. K., Sierra, D. B., Lopes, N. H., et al. (2010) · JAMA · doi:10.1001/jama.2010.1446 · Cited by 1,054
Koch, C. G., Li, L., Duncan, A. I., Mihaljevic, T., Cosgrove, D. M., Loop, F. D., Starr, N. J., & Blackstone, E. H. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217920.48559.d8 · Cited by 936
Self-citationEffect of blood transfusions on subsequent kidney transplants.
Opelz, G., SENGAR, D. P. S., Mickey, M. R., & Terasaki, P. I. (1973) · PubMed · Cited by 845
Effect of blood transfusion on long-term survival after cardiac operation
Engoren, M. C., Habib, R. H., Zacharias, A., Schwann, T. A., Riordan, C. J., & Durham, S. J. (2002) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)03766-9 · Cited by 683
Hill, G. E., Frawley, W. H., Griffith, K. E., Forestner, J. E., & Minei, J. P. (2003) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000022460.21283.53 · Cited by 556
Efficacy and Safety of Epoetin Alfa in Critically Ill Patients
Corwin, H. L., Gettinger, A., Fabian, T. C., May, A., Pearl, R. G., Heard, S., An, R., Bowers, P. J., Burton, P., Klausner, M. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071533 · Cited by 545
Cited by
Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update
Anderson, D. J., Podgorny, K., Berríos-Torres, S. I., Bratzler, D. W., Dellinger, E. P., Greene, L., Nyquist, A.-C., Saiman, L., Yokoe, D. S., Maragakis, L. L., et al. (2014) · Infection Control & Hospital Epidemiology · doi:10.1017/s0899823x00193869 · Cited by 369
Metadata
- Authors
- Horvath, K. A., Acker, M. A., Chang, H., Bagiella, E., Smith, P. K., Iribarne, A., Kron, I. L., Lackner, P., Argenziano, M., Ascheim, D. D., Gelijns, A. C., Michler, R. E., Van Patten, D., Puskas, J. D., O'Sullivan, K., Kliniewski, D., Jeffries, N. O., O'Gara, P. T., Moskowitz, A. J., & Blackstone, E. H.
- Venue
- The Annals of Thoracic Surgery
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 95
- Issue
- 6
- Pages
- 2194-2201
- ISSN
- 0003-4975 (ISSN-L)
- OpenAlex
- W2074857397
- Cited by
- 306
- References
- 33
- FWCI
- 20.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Horvath, K. A., Acker, M. A., Chang, H., Bagiella, E., Smith, P. K., Iribarne, A., Kron, I. L., Lackner, P., Argenziano, M., Ascheim, D. D., Gelijns, A. C., Michler, R. E., Van Patten, D., Puskas, J. D., O'Sullivan, K., Kliniewski, D., Jeffries, N. O., O'Gara, P. T., Moskowitz, A. J., & Blackstone, E. H. (2013). Blood Transfusion and Infection After Cardiac Surgery. The Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2012.11.078
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
