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Cited by 6Lipoproteins and Cardiovascular HealthCerebrovascular and Carotid Artery DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Association of remnant cholesterol with intra-and extra-cranial atherosclerosis in Chinese community population

Open access
Wang, Anxin, Tian, Xue, Zuo, Yingting, Wu, Jianwei, Tang, Hefei, Wang, Yongjun, Zhao, Xingquan·2021·Atherosclerosis Plus
DOI 10.1016/j.athplu.2021.10.002PMC PMC9833241
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Abstract

Background: Multifocal atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than single artery affected. Triglyceride-rich lipoprotein (TRL) has been implicated in the early development of atherosclerosis.However, evidence on the effect of remnant cholesterol, a major atherogenic component of TRL, on multifocal atherosclerosis in Chinese health asymptomatic subjects is insufficient. This study aimed to investigate the association of remnant cholesterol with intra- and extra-cranial atherosclerosis in Chinese population. Methods: This study enrolled 3665 participants (median age 52.31 years) from the Asymptomatic Polyvascular Abnormalities Community study. Parameters of intra- and extra-cranial atherosclerosis includes intracranial artery stenosis (ICAS), carotid plaque, carotid artery stenosis (CAS), and carotid hypertrophy (intima-media thickness >0.9 mm). Logistic regression was used to assess these associations. Results: for trend <0.0001). In the multivariable-adjusted model, the odds ratio with 95% confidence interval comparing participants in Q4 versus Q1 of remnant cholesterol was 1.73 (1.29-2.31) for ICAS, 1.54 (1.22-1.94) for carotid plaque, 1.47 (1.17-1.84) for CAS, and 1.93 (1.48-2.52) for carotid hypertrophy, respectively. Furthermore, multivariable-adjusted spline regression showed S-shaped associations between remnant cholesterol and these outcomes. Conclusion: Individuals with a high level of remnant cholesterol had a higher risk of intra- and extra-cranial atherosclerosis in Chinese population. Interventions aimed at reducing remnant cholesterol to prevent atherosclerotic diseases warrant further investigations.

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  • Elevated levels of cholesterol-enriched remnant lipoproteins contribute to the development of premature coronary and peripheral atherosclerosis.

    “As a result, elevated levels of cholesterol-enriched remnant lipoproteins contribute to the development of premature coronary [22,23,24] and peripheral [25,26] atherosclerosis.”

    From Spectrum and Prevalence of Rare APOE Variants and Their Association with Familial Dysbetalipoproteinemia (2024) · cites this paper as [26]

    The Discussion (page unavailable) reports that higher remnant cholesterol was associated with intracranial and extracranial carotid atherosclerosis in asymptomatic Chinese adults. This lends some support to the cited peripheral-atherosclerosis point, but the paper does not establish premature or peripheral-limb disease. Its Limitations section explicitly says the cross-sectional design limits causal inference, so it does not establish that remnant lipoproteins contribute to disease development. (LLM, conf=0.84)

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Cited by

Sorted by citations

Authors
Wang, A., Tian, X., Zuo, Y., Wu, J., Tang, H., Wang, Y., & Zhao, X.
Affiliations
Capital Medical University (CN)
Corresponding author
  • Wang, Yongjun
  • Zhao, Xingquan
ORCID
Venue
Atherosclerosis Plus
Publisher
Elsevier BV
Published
2021-12
Volume
46
Pages
20-26
ISSN
2667-0895 (ISSN-L)
DOI
10.1016/j.athplu.2021.10.002
PMC
PMC9833241
OpenAlex
W3209554498
Cited by
6
References
2
Citations by year
2026: 2 · 2024: 3 · 2023: 1
FWCI
0.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Atherosclerosis Plus (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Beijing Natural Science Foundation (Z200016)
  • National Natural Science Foundation of China (81870905, U20A20358)
  • CAMS Innovation Fund for Medical Sciences (2019-I2M-5-029)
  • Beijing Municipal Science and Technology Commission (D171100003017002)
  • China Academy of Space Technology (2018QNRC001)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
remnant cholesterol, triglyceride-rich lipoproteins, intracranial atherosclerosis, extracranial atherosclerosis, intracranial stenosis, carotid artery stenosis, carotid plaque, carotid intima-media thickness, multifocal atherosclerosis, Chinese population

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