Other autonomic neuropathies associated with ganglionic antibody
Open accessAbstract
The acetylcholine receptor ganglionic (G-AchR) antibody is a very specific serologic test for autoimmune autonomic ganglionopathy. The spectrum of autoimmune (or presumed to be autoimmune) autonomic disorders, however, is quite broad and positivity to this antibody has been reported in a variety of other conditions, albeit infrequent and with low titer. This review describes the autonomic neuropathies most frequently encountered in clinical practice in which an autoimmune etiology is suspected. They include a chronic form (pure autonomic failure) and limited autonomic neuropathies with predominant involvement of one neurotransmitter type (i.e., cholinergic vs. adrenergic) or one system (such as the gastrointestinal system) or a distal small fiber dysfunction. In each of these conditions, occasional positivity to the G-AchR antibody has been found, but the pathogenetic significance of such finding is still uncertain. Other antigens and antibodies yet to be identified are more likely to be responsible in these disorders.
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Sandroni and Low demonstrated occasional positivity to gAChR antibodies in POTS patients.
“Sandroni and Low demonstrated occasional positivity to gAChR antibodies in POTS patients.10”
From Autoimmune postural orthostatic tachycardia syndrome (2018) · cites this paper as [10]
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References 24 · Cited by 63
- Authors
- Sandroni, P., & Low, P. A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Low, Phillip A.
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 146
- Issue
- 1-2
- Pages
- 13-17
- ISSN
- 1566-0702 (ISSN-L)
- PMC
- PMC2671239
- OpenAlex
- W2049574145
- Cited by
- 63
- References
- 24
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 2 · 2013: 6 · 2012: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (P01NS044233, P50NS032352)
- Topics
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- autoimmune autonomic ganglionopathy, autonomic neuropathy, pure autonomic failure, small fiber neuropathy, autoimmune etiology, serological markers
- MeSH terms
- Adult, Aged, Autoantibodies, Autoantigens, Autonomic Nervous System Diseases, Chronic Disease, Female, Ganglia, Autonomic, Humans, Hypohidrosis, Intestinal Pseudo-Obstruction, Male, Receptors, Nicotinic, Shy-Drager Syndrome, Virus Diseases, Autoimmune Diseases of the Nervous System, Pure Autonomic Failure, Postural Orthostatic Tachycardia Syndrome, Young Adult
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