Correct laboratory approach to APS diagnosis and monitoring
Abstract
Triple positivity (positive Lupus Anticoagulant, anticardiolipin and anti β2-glycoptrotein I antibodies) identifies the pathogenic autoantibody (anti Domain I of β2-glycoptroteinI) that is present in patients with definite Antiphospholipid Syndrome (APS). This is supported by the fact that aβ2GPI antibodies obtained by affinity purification in these patients possess LA activity. Moreover, patients and carriers of this profile carry a much higher risk of thrombosis and pregnancy loss than APS patients with positivity for only one of the tests. Thus, very different risk categories exist among patients with APS as well as among carriers of aPL. Clinical studies and interventional trials should first take these high risk subjects into consideration.
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In our study, triple positivity was strongly associated with thrombosis.
“In our study, triple positivity was strongly associated with thrombosis, which is consistent with previous studies. 19,23”
From Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2021) · cites this paper as [23]
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References 37 · Cited by 62
- Authors
- Pengo, V., Banzato, A., Denas, G., Jose, S. P., Bison, E., Hoxha, A., & Ruffatti, A.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Pengo, V.
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 12
- Issue
- 8
- Pages
- 832-834
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2014136441
- Cited by
- 62
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 9 · 2015: 5 · 2014: 20 · 2013: 6 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, triple positivity, lupus anticoagulant, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, affinity purification, thrombosis risk, miscarriage, risk stratification
- MeSH terms
- Autoantibodies, Female, Humans, Pregnancy, Pregnancy Complications, Hematologic, Thrombosis, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, beta 2-Glycoprotein I
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