Benefits of physical exercise on executive functions in older people with Parkinson's disease
Abstract
The benefits of physical exercise on cognitive functioning have been reported in the literature, but the potential benefits to slow the eventual decline in executive functioning (EF) caused by neurodegeneration from Parkinson's Disease (PD) have rarely been studied. Thus the objective of this study was to analyze the effects of a multimodal physical exercise program on EF in older people with Parkinson's disease. The EF of the older people was evaluated by neuropsychological testing, and for confounding variables such as attention, depressive symptoms and anxiety, before and after intervention. The 20 participants were assigned into Control (CG) and Trained (TG) Groups. The TG participated in generalized physical training for 6 months. The ANOVA showed a significant interaction (p<.05) that indicated a beneficial contribution of training on EF. No significant interactions were found in the results for confounding variables between groups and pre- and post-intervention, which supports the beneficial findings of physical exercise training on EF.
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Both MPTP and 6-OHDA toxins lead to destruction of nigrostriatal dopamine neurons and subsequent depletion of dopamine in the dorsal striatum.
“Both toxins lead to the destruction of nigrostriatal DA neurons and the subsequent depletion of DA in the dorsal striatum.”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [71]
Two commonly used models of dopamine depletion include the MPTP-lesioned mouse and the 6-OHDA-lesioned rat.
“Two commonly used models of DA-depletion include the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse and the 6-hydroxydopamine (6-OHDA)-lesioned rat models.71”
From Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease (2013) · cites this paper as [71]
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References 64 · Cited by 221
- Authors
- Tanaka, K., Quadros, A. C. D., Santos, R. F., Stella, F., Gobbi, L. T. B., & Gobbi, S.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Associação Fundo de Incentivo à Pesquisa (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Corresponding author
- Tanaka, Kátia
- Venue
- Brain and Cognition
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 69
- Issue
- 2
- Pages
- 435-441
- ISSN
- 0278-2626 (ISSN-L)
- OpenAlex
- W2030012686
- Cited by
- 221
- References
- 64
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 13 · 2018: 22 · 2017: 17 · 2016: 20 · 2015: 21 · 2014: 17 · 2013: 22 · 2012: 14
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Cognition (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Keywords
- Parkinson's disease, physical activity, executive function, older adults, cognitive decline, neurodegeneration, attention, depressive symptoms, anxiety
- MeSH terms
- Aged, Analysis of Variance, Anxiety, Attention, Depression, Female, Humans, Male, Mental Processes, Neuropsychological Tests, Parkinson Disease, Exercise
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