Commentary on: ‘Old and new data, new issues: The mitochondrial Δψ’ by H. Tedeschi
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A recent review [H.Tedeschi, Old and New Data, New Issues: the Mitochondrial Deltapsi, Biochim. Biophys. Acta, Bioenerg. (2005)] has questioned the validity of experiments performed more than 30 years ago that provided the first quantitative estimates of the protonmotive force generated by mitochondria. This commentary explains that the review author's confusion stems from ignoring the data in these papers on the trans-membrane pH gradient.
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The negative plasma membrane potential drives TPP+ movement from extracellular space into cytoplasm up to 10-fold, and TPP+ accumulates within mitochondria up to several hundred fold due to higher mitochondrial membrane potential.
“This is achieved because the cells’ negative plasma membrane potential (-30mV to -60mV) drives the movement of TPP+ from the extracellular space into the cytoplasmic compartment up to 10-fold. TPP+ can further accumulate within the mitochondria up to several hundred fold due to the higher mitochondrial membrane potential (−140 to −180 mV) [15,16].”
From Mitochondrially targeted compounds and their impact on cellular bioenergetics (2013) · cites this paper as [16]
The commentary’s discussion of lipophilic cations (section labeled Abstract; page unavailable) identifies TPP+ as a probe of mitochondrial membrane potential. It does not describe TPP+ moving from extracellular space into cytoplasm, or give the claimed plasma-membrane and mitochondrial potential ranges or 10-fold and several-hundred-fold accumulation figures. (LLM, conf=0.78)
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Mitochondrially targeted compounds and their impact on cellular bioenergetics
Reily, C., Mitchell, T., Chacko, B. K., Benavides, G. A., Murphy, M. P., & Darley-Usmar, V. M. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.009 · Cited by 227 · see citing works
- Authors
- Nicholls, D. G.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Nicholls, David G.
- ORCID
- Nicholls, David G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 1710
- Issue
- 2-3
- Pages
- 63-65
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W1968912767
- Cited by
- 25
- References
- 0
- Citations by year
- 2024: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
- Keywords
- mitochondrial membrane potential, proton motive force, mitochondrial proton gradient, mitochondrial bioenergetics
- MeSH terms
- Animals, Hydrogen-Ion Concentration, Membrane Potentials, Mitochondria, Reproducibility of Results, Proton-Motive Force, Rats
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