The physiological regulation of uncoupling proteins
Open accessAbstract
Despite the enormous interest in the roles of novel uncoupling proteins, there is still great uncertainty as to their mechanism and regulation. The regulation of the architypal uncoupling protein 1 from brown adipose tissue was elucidated more than 20 years ago. This review suggests that a number of the approaches and criteria developed for the study of UCP1 could with profit be applied to current investigations of the novel UCPs.
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ANT, rather than UCP2, may be most responsible for the antioxidant mechanism in heart muscle mitochondria.
“However, ANT, rather than UCP2, may be most responsible for the antioxidant mechanism in heart muscle mitochondria (238).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [238]
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References 54 · Cited by 183
- Authors
- Nicholls, D. G.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Nicholls, David G.
- ORCID
- Nicholls, David G.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 1757
- Issue
- 5-6
- Pages
- 459-466
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2080057943
- Cited by
- 183
- References
- 54
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 14 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 11
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01 AG1440)
- National Institute of Neurological Disorders and Stroke (R01 NS4 1908, R01NS041908)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- uncoupling proteins, UCP1, brown adipose tissue, protein regulation, thermogenesis, mitochondrial uncoupling
- MeSH terms
- Uncoupling Protein 1, Animals, Biological Transport, Adipose Tissue, Brown, Carrier Proteins, Fatty Acids, Ion Channels, Membrane Proteins, Protons, Purine Nucleotides, Lipid Peroxidation, Ion Channel Gating, Mitochondrial Proteins
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