The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
White matter integrity and vulnerability to Alzheimer’s disease: preliminary findings and future directions
Open accessAbstract
Neuroimaging biomarkers that precede cognitive decline have the potential to aid early diagnosis of Alzheimer's disease (AD). A body of diffusion tensor imaging (DTI) work has demonstrated declines in white matter (WM) microstructure in AD and its typical prodromal state, amnestic mild cognitive impairment. The present review summarizes recent evidence suggesting that WM integrity declines are present in individuals at high AD-risk, prior to cognitive decline. The available data suggest that AD-risk is associated with WM integrity declines in a subset of tracts showing decline in symptomatic AD. Specifically, AD-risk has been associated with WM integrity declines in tracts that connect gray matter structures associated with memory function. These tracts include parahippocampal WM, the cingulum, the inferior fronto-occipital fasciculus, and the splenium of the corpus callosum. Preliminary evidence suggests that some AD-risk declines are characterized by increases of radial diffusivity, raising the possibility that a myelin-related pathology may contribute to AD onset. These findings justify future research aimed at a more complete understanding of the neurobiological bases of DTI-based declines in AD. With continued refinement of imaging methods, DTI holds promise as a method to aid identification of presymptomatic AD. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.
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“AD pathology in the white matter includes the loss of myelin and a decrease in oligodendrocyte proteins [62–68].”
From Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts (2016) · cites this paper as [68]
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“Despite these previous findings in symptomatic Alzheimer’s disease participants, white matter changes in the preclinical phase before the occurrence of cognitive impairment have been examined only in a few studies (Gold et al., 2012).”
From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Gold et al., 2012
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“This discrepancy may be attributed to the distinct characteristics of these metrics (42).”
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“Such microstructural alterations often appear early in the disease course and are closely associated with both pathological hallmarks and cognitive decline [6].”
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“…high particularly in large myelinated fibers (e.g., corpus callosum), while MD is more sensitive to subtle alterations in microstructure, given its assessment of overall diffusion in all directions (Acosta-Cabronero et al., 2010; Assaf and Pasternak, 2008; Figley et al., 2022; Gold et al., 2012).”
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Metadata
- Authors
- Gold, B. T., Johnson, N. F., Powell, D. K., & Smith, C. D.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Gold, Brian T.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 1822
- Issue
- 3
- Pages
- 416-422
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3213315
- OpenAlex
- W1984939243
- Cited by
- 170
- References
- 68
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 12 · 2014: 15 · 2013: 16 · 2012: 6
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NINDS (R01 NS-36660)
- NIA (R01 AG033036)
- NSF (BCS-0814302)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, white matter integrity, diffusion tensor imaging, amnestic mild cognitive impairment, neuroimaging biomarkers, early diagnosis, radial diffusivity, myelin pathology, cingulum, inferior fronto-occipital fasciculus, splenium of corpus callosum, white matter microstructure
- MeSH terms
- Alzheimer Disease, Brain, Cognition Disorders, Humans, Nerve Fibers, Myelinated, Risk Factors, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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