Selective changes in white matter integrity in MCI and older adults with cognitive complaints
Open accessAbstract
Background White matter changes measured using diffusion tensor imaging have been reported in Alzheimer's disease and amnestic mild cognitive impairment, but changes in earlier pre-mild cognitive impairment stages have not been fully investigated. Methods In a cross-sectional analysis, older adults with mild cognitive impairment (n=28), older adults with cognitive complaints but without psychometric impairment (n=29) and healthy controls (n=35) were compared. Measures included whole-brain diffusion tensor imaging, T1-weighted structural magnetic resonance imaging, and neuropsychological assessment. Diffusion images were analyzed using Tract-Based Spatial Statistics. Voxel-wise fractional anisotropy and mean, axial, and radial diffusivities were assessed and compared between groups. Significant tract clusters were extracted in order to perform further region of interest comparisons. Brain volume was estimated using FreeSurfer based on T1 structural images. Results The mild cognitive impairment group showed lower fractional anisotropy and higher radial diffusivity than controls in bilateral parahippocampal white matter. When comparing extracted diffusivity measurements from bilateral parahippocampal white matter clusters, the cognitive complaint group had values that were intermediate to the mild cognitive impairment and healthy control groups. Group difference in diffusion tensor imaging measures remained significant after controlling for hippocampal atrophy. Across the entire sample, diffusion tensor imaging indices in parahippocampal white matter were correlated with memory function. Conclusions These findings are consistent with previous results showing changes in parahippocampal white matter in Alzheimer's disease and mild cognitive impairment compared to controls. The intermediate pattern found in the cognitive complaint group suggests the potential of diffusion tensor imaging to contribute to earlier detection of neurodegenerative changes during prodromal stages. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.
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In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum, whereas some studies reported no statistically significant differences in diffusion metrics.
“In individuals with SCD, significantly decreased FA and increased MD have been observed in the cerebrum, mainly in the hippocampal body, entorhinal cortex and parahippocampal gyrus, uncinated fasciculi, longitudinal fasciculi and corpus callosum [77, 78, 109–113], whereas Kiuchi et al. and Viviano et al. reported no statistically significant differences in diffusion metrics [114, 115].”
From Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease (2020) · cites this paper as [110]
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- Authors
- Wang, Y., West, J. D., Flashman, L. A., Wishart, H. A., Santulli, R. B., Rabin, L. A., Pare, N., Arfanakis, K., & Saykin, A. J.
- Affiliations
- Indiana University Indianapolis (US)
- Indiana University School of Medicine (US)
- Dartmouth College (US)
- The Graduate Center, CUNY (US)
- Illinois Institute of Technology (US)
- Corresponding author
- Saykin, Andrew J.
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 1822
- Issue
- 3
- Pages
- 423-430
- ISSN
- 0925-4439 (ISSN-L)
- PMC
- PMC3235544
- OpenAlex
- W2027184912
- Cited by
- 110
- References
- 10
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 12 · 2018: 13 · 2017: 6 · 2016: 10 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 1
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- National Institutes of Health
- NIA R01 AG19771
- Indiana Economic Development Corporation
- IEDC #87884
- NIA P30 AG10133-18S1 Core Supplement
- Siemens AG
- UL1 RR025761
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- mild cognitive impairment, cognitive complaints, white matter integrity, fractional anisotropy, radial diffusivity, diffusion tensor imaging, hippocampal atrophy, memory function, prodromal Alzheimer's disease, brain aging, older adults
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Cognition Disorders, Cross-Sectional Studies, Female, Humans, Male, Memory, Nerve Fibers, Myelinated, Neuropsychological Tests, Anisotropy, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Cognitive Dysfunction
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