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Cited by 73Liver physiology and pathologyLiver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Dendritic cells and liver fibrosis

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Rahman, Adeeb H., Aloman, Costica·2013·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
DOI 10.1016/j.bbadis.2013.01.005PMC PMC3641166
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Abstract

Dendritic cells are a relative rare population of specialized antigen presenting cells that are distributed through most lymphoid and non-lymphoid tissues and play a critical role in linking the innate and adaptive arms of the immune system. The liver contains a heterogeneous population of dendritic cells that may contribute to liver inflammation and fibrosis through a number of mechanisms. This review summarizes current knowledge on the development and characterization of liver dendritic cells and their potential impact on liver fibrosis. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

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  • The intensity of the Th1 response by ADH-specific T cells in active drinkers, as indicated by IFN-ƴ production, correlated with disease severity.

    “Furthermore, the intensity of the Th1 response by ADH-specific T cells in active drinkers, as indicated by IFN-ƴ production, correlated with disease severity (59).”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [59]

    The Subsets of liver dendritic cells section discusses interferon production by dendritic cells during hepatitis C infection, not IFN-γ production by ADH-specific T cells in active drinkers. Searches for ADH-specific T cells, active drinkers, and the claimed correlation with disease severity found no passage addressing that result. (LLM, conf=0.76)

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  • In a study of patients with alcohol-related cirrhosis, active drinkers exhibited antigen-specific peripheral T-cell responses against alcohol dehydrogenase, which were largely absent in cirrhotic patients who had abstained from alcohol for more than 6 months.

    “In a study of patients with alcohol-related cirrhosis, active drinkers exhibited antigen-specific peripheral T-cell responses against the ethanol-metabolizing enzyme alcohol dehydrogenase (ADH), which were largely absent in cirrhotic patients who had abstained from alcohol for >6 months.”

    From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [59]

    Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.

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References 51 · Cited by 73

Research works printed but not linked: 49

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Authors
Rahman, A. H., & Aloman, C.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Aloman, Costica
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2013-07
Volume
1832
Issue
7
Pages
998-1004
ISSN
0925-4439 (ISSN-L)
DOI
10.1016/j.bbadis.2013.01.005
PMC
PMC3641166
OpenAlex
W2021097748
Cited by
73
References
51
Citations by year
2026: 5 · 2025: 7 · 2024: 11 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 7 · 2013: 3
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK088954)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
dendritic cells, liver fibrosis, antigen presentation, liver inflammation, dendritic cell development, innate and adaptive immunity
MeSH terms
Dendritic Cells, Hepatitis, Humans, Liver Cirrhosis

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