Protective features of peripheral monocytes/macrophages in stroke
Open accessAbstract
Hematogenous recruitment of monocytes and macrophages has traditionally been viewed as a harmful process causing exacerbation of brain injury after stroke. However, emerging findings suggest equally important protective features. Inflammatory monocytes are rapidly recruited to ischemic brain via a CCR2-dependent pathway and undergo secondary differentiation in the target tissue towards non-inflammatory macrophages, mediating neuroprotection and repair of the ischemic neurovascular unit. In contrast, independent recruitment of non-inflammatory monocytes via CX3CR1 does not occur. Thus, protective features of hematogenous macrophages mainly depend on initial CCR2-dependent cell recruitment. Under therapeutic considerations, specific modulation of monocyte-derived macrophages will therefore be more appropriate than non-selectively blocking their hematogenous recruitment. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
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The CCL2-CCR2 axis is implicated in the infiltration of monocytes into the inflamed brain.
“The CCL2-CCR2 axis has been implicated in the infiltration of monocytes into the inflamed brain.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [229]
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References 107 · Cited by 88
Research works printed but not linked: 1
- R. Rajakariar, et al., Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2, Proc. Natl. Acad. Sci. U. S. A. 104 (52) (2007) 20979-20984.
- Authors
- Gliem, M., Schwaninger, M., & Jander, S.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- University of Lübeck (DE)
- Corresponding author
- Jander, Sebastian
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 1862
- Issue
- 3
- Pages
- 329-338
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2236679345
- Cited by
- 88
- References
- 107
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 4 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 14 · 2017: 6 · 2016: 7 · 2015: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SCHW 416/7-1, JA 690/8-1)
- European Union's Seventh Framework Programme (607962)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- stroke, monocytes, macrophages, CCR2, CX3CR1, neuroinflammation, neuroprotection, ischemic brain injury, monocyte differentiation
- MeSH terms
- Neuroprotection, Animals, Brain, Humans, Inflammation, Macrophages, Monocytes, Stroke, Receptors, CCR2, Protective Factors
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