Drosophila as a model for ageing
Open accessAbstract
Drosophila melanogaster has been a key model in developing our current understanding of the molecular mechanisms of ageing. Of particular note is its role in establishing the evolutionary conservation of reduced insulin and IGF-1-like signaling in promoting healthy ageing. Capitalizing on its many advantages for experimentation, more recent work has revealed how precise nutritional and genetic interventions can improve fly lifespan without obvious detrimental side effects. We give a brief summary of these recent findings as well as examples of how they may modify ageing via actions in the gut and muscle. These discoveries highlight how expanding our understanding of metabolic and signaling interconnections will provide even greater insight into how these benefits may be harnessed for anti-ageing interventions.
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Inbreeding can have a negative impact on lifespan, as observed across various species, from fruit flies and butterflies to cattle or dogs.
“Furthermore, inbreeding can have a negative impact on lifespan, as it has been observed across various species, from fruit flies [193] and butterflies [194], to cattle [195] or dogs [196,197].”
From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [193]
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References 189 · Cited by 273
- Authors
- Piper, M. D. W., & Partridge, L.
- Affiliations
- Monash University (AU)
- Max Planck Institute for Biology of Ageing (DE)
- Corresponding author
- Partridge, Linda
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 1864
- Issue
- 9
- Pages
- 2707-2717
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2758538841
- Cited by
- 273
- References
- 189
- Citations by year
- 2026: 27 · 2025: 48 · 2024: 47 · 2023: 45 · 2022: 36 · 2021: 33 · 2020: 19 · 2019: 13 · 2018: 5
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Australian Research Council (FT150100237)
- Wellcome Trust UK (098565/Z/12/Z)
- Max Planck Society
- European Research Council (268739)
- European Union Seventh Framework Programme (FP7/2007-2013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Drosophila melanogaster, aging, lifespan extension, insulin signaling, IGF-1 signaling, evolutionary conservation, dietary intervention, genetic interventions, intestine, muscle, anti-aging interventions, metabolic signaling
- MeSH terms
- Aging, Animals, Diet, Drosophila melanogaster, Genetic Engineering, Insulin, Insulin-Like Growth Factor I, Longevity, Muscles, Protein Kinases, Research, Signal Transduction, Nutrition Assessment, Models, Animal, Drosophila Proteins, Gastrointestinal Tract, Activating Transcription Factor 4, Metabolic Networks and Pathways, AMP-Activated Protein Kinases, TOR Serine-Threonine Kinases
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