The chemistry and biological activities of N-acetylcysteine

Samuni, Yuval, Goldstein, Sara, Dean, Olivia M., Berk, Michael·2013·Biochimica et Biophysica Acta (BBA) - General Subjects
DOI 10.1016/j.bbagen.2013.04.016

Cites (264)

Items 201–264 of 264

  1. Redox Paradox: Effect of N-Acetylcysteine and Serum on Oxidation Reduction–Sensitive Mitogen-Activated Protein Kinase Signaling Pathways
    Edward D. Chan, David W. H. Riches, Carl W. White · 2001 · American Journal of Respiratory Cell and Molecular Biology
  2. N-Acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps
    Richard D. Estensen, Michael Levy, Steven J Klopp, Arthur R. Galbraith, Jack S. Mandel, Joyce A Blomquist, Lee W. Wattenberg · 1999 · Cancer Letters
  3. Protection from oxidation enhances the survival of cultured mesencephalic neurons
    Carol A. Colton, Fernando Pagán, Julie C. Snell, Joel S. Colton, Alex C. Cummins, Daniel L. Gilbert · 1995 · Experimental Neurology
  4. N-acetylcysteine inhibits IL-8 and MMP-9 release and ICAM-1 expression by bronchoalveolar cells from interstitial lung disease patients
    Dorota Magdalena Radomska-Leśniewska, Ewa Skopińska-Różewska, Ewa A. Jankowska-Steifer, Małgorzata Sobiecka, Anna M. Sadowska, Agata Hevelke, Jacek Malejczyk · 2010 · Pharmacological Reports
  5. Lack of effect of oral N-acetylcysteine on the acute dialysis-related lowering of total plasma homocysteine in hemodialysis patients
    Andrew G. Bostom, Douglas G. Shemin, David C. Yoburn · 1996 · Atherosclerosis
  6. Effect of N‐acetylcysteine on the early expression of inflammatory markers in the retina and plasma of diabetic rats
    Gina Tsai, Jing Z Cui, Husnain Syed, Zhengyuan Xia, Uğur Özerdem, John Hugh McNeill, Joanne Aiko Matsubara · 2009 · Clinical and Experimental Ophthalmology
  7. Oxygen homeostasis, thiol equilibrium and redox regulation of signalling transcription factors in the alveolar epithelium
    John J. Haddad · 2002 · Cellular Signalling
  8. Systemic administration of N‐acetylcysteine protects dopaminergic neurons against 6‐hydroxydopamine‐induced degeneration
    Ana Muñoz, Pablo Rey, Ramón Soto‐Otero · 2004 · Journal of Neuroscience Research
  9. N-Acetylcysteine Decreases Angiotensin II Receptor Binding in Vascular Smooth Muscle Cells
    Michael E. Ullian, Andrew K. Gelasco, Wayne R. Fitzgibbon, Christy Beck, Thomas A. Morinelli · 2005 · Journal of the American Society of Nephrology
  10. N-acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death
    Motoki Arakawa, Nobuyuki Ushimaru, Nobuhiro Osada, Tetsuro Oda, Kumiko Ishige, Yoshihisa Ito · 2006 · Neuroscience Research
  11. Characterizing N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) binding for lead poisoning treatment
    Weiqing Chen, Nuran Erçal, Tien Huynh · 2011 · Journal of Colloid and Interface Science
  12. Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects
    Henne A. Kleinveld, Pierre N.M. Demacker, Anton F. H. Stalenhoef · 1992 · European Journal of Clinical Pharmacology
  13. The Antioxidant N-Acetylcysteine Promotes Atherosclerotic Plaque Stabilization Through Suppression of RAGE, MMPs and NF-κB in ApoE-Deficient Mice
    Yonggang Lu, Weiwei Qin, Tao Shen · 2011 · Journal of Atherosclerosis and Thrombosis
  14. Effect of N-acetylcysteine and deferoxamine on endogenous antioxidant defense system gene expression in a rat hepatocyte model of cocaine cytotoxicity
    Asunción Zaragoza, Carmen Díez‐Fernández, Alberto M. Alvarez · 2000 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  15. Protective effects of N-acetylcysteine against cadmium-induced damage in cultured rat normal liver cells
    Odewumi · 2010 · International Journal of Molecular Medicine
  16. Reduced nonprotein thiols inhibit activation and function of MMP-9: Implications for chemoprevention
    Ping Pei, Michael P. Horan, Russ Hille, Craig F. Hemann, Steven P. Schwendeman, Susan R. Mallery · 2006 · Free Radical Biology and Medicine
  17. N-acetyl-cysteine in the treatment of Parkinson’s disease. What are we waiting for?
    Marcos Martı́nez · 2012 · Medical Hypotheses
  18. Evidence that N-acetylcysteine inhibits TNF-α-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase
    Matthias D. Sury, Manuela Frese‐Schaper, Miranda K. Mühlemann · 2006 · Free Radical Biology and Medicine
  19. DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase
    Jiqin Liu, Yasuhiro Yoshida, Uki Yamashita · 2008 · Molecular Immunology
  20. A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain
    Gerardo Guillermo Mackenzie, Gabriela Alejandra Salvador, Carolina B. Romero, Carl L. Keen, Patricia I. Oteiza · 2011 · Free Radical Biology and Medicine
  21. Inhibitory Effects of N-acetylcysteine on Superoxide Anion Generation in Human Polymorphonuclear Leukocytes
    Victoria Villagrasa, Julio Cortijo, Miguel Martí‐Cabrera · 1997 · Journal of Pharmacy and Pharmacology
  22. N-acetylcysteine as an anti-oxidant and anti-inflammatory drug and its some clinical applications
    Dorota Magdalena Radomska-Leśniewska, Piotr Skopiński · 2012
  23. Detoxification of mercury species—an in vitro study with antidotes in human whole blood
    Stefan Trümpler, Sascha Nowak, Björn Meermann · 2009 · Analytical and Bioanalytical Chemistry
  24. Antiapoptotic and antigenotoxic effects of N-acetylcysteine in human cells of endothelial origin.
    Maria Grazia Aluigi, S. De Flora, Francesco D’Agostini, Adriana Albini, Gianfranco Fassina · 2000 · PubMed
  25. A Double-blind, Cross-over, Study of Oral N-Acetylcysteine in Sjögren’s Syndrome
    M. T. Walters, C. E. Rubin, S J Keightley · 1986 · Scandinavian Journal of Rheumatology
  26. Role of glutathione and other endogenous thiols in radiation protection
    James B. Mitchell, John E. Biaglow, Angelo Russo · 1988 · Pharmacology & Therapeutics
  27. Role of Organic Anion and Amino Acid Carriers in Transport of Inorganic Mercury in Rat Renal Basolateral Membrane Vesicles: Influence of Compensatory Renal Growth
    Lawrence Harold Lash, Sarah E. Hueni, David Alan Putt · 2005 · Toxicological Sciences
  28. p53-Independent Inhibition of Proliferation and p21Waf1/Cip1-Modulated Induction of Cell Death by the Antioxidants N-acetylcysteine and Vitamin E
    Jennifer L. Nargi‐Aizenman, Rajiv R. Ratan, Diane E. Griffin · 1999 · Neoplasia
  29. Effect of pH on the Reactivity of the Carbonate Radical in Aqueous Solution
    Schoen‐Nan Chen, Morton Z. Hoffman · 1975 · Radiation Research
  30. N-acetyl-l-cysteine fosters inactivation and transfer to endolysosomes of c-Src
    Ewa Krystyna Krasnowska, Eugenia Pittaluga, Anna Maria Brunati, Roberto Brunelli, Graziella Costa, Marco De Spirito, Annalucia Serafino, Fulvio Ursini, Tiziana Parasassi · 2008 · Free Radical Biology and Medicine
  31. Inhibitory effects of N-acetylcysteine on invasion and MMP-9 production of T24 human bladder cancer cells
    理 川上 · 2001 · Medical Entomology and Zoology
  32. Metabolic, Desmutagenic and Anticarcinogenic Effects of N-Acetylcysteine
    S. De Flora, Antônio Rossi, Antonio DE FLORA · 2009 · Respiration
  33. N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production
    Kana Shimada, Toshinori Murayama, Masayuki Yokode, Toru Kita, Hiroyasu Uzui, Takanori Ueda, Jong-Dae Lee, Chiharu Kishimoto · 2009 · Circulation Journal
  34. N-Acetylcysteine Enhances Antibody-Dependent Cellular Cytotoxicity in Neutrophils and Mononuclear Cells from Healthy Adults and Human Immunodeficiency Virus-Infected Patients
    Robert L. Roberts, Vanita R. Aroda, Bonnie J. Ank · 1995 · The Journal of Infectious Diseases
  35. Relationship between Phosphorylated Histone H2AX Formation and Cell Survival in Human Microvascular Endothelial Cells (HMEC) as a Function of Ionizing Radiation Exposure in the Presence or Absence of Thiol-Containing Drugs
    Yasushi Kataoka, Jeffrey S. Murley, Kenneth L. Baker, David J. Grdina · 2007 · Radiation Research
  36. Electrochemical Oxidation ofN-Acyldopamines and Regioselective Reactions of Their Quinones withN-Acetylcysteine and Thiourea
    Xin Huang, Rongda Xu, M. Dale Hawley · 1998 · Archives of Biochemistry and Biophysics
  37. The effects of antioxidants on radiation-induced apoptosis pathways in TK6 cells
    Ayelet M. Samuni, William DeGraff, John A. Cook, Murali Cherukuri Krishna, Angelo Russo, James B. Mitchell · 2004 · Free Radical Biology and Medicine
  38. Intravenous N-Acetylcysteine in the Prevention of Contrast Media-Induced Nephropathy
    Spencer M. Anderson, Zoon H. Park, Ramesh V. Patel · 2011 · Annals of Pharmacotherapy
  39. N-Acetylcysteine Attenuates Copper Overload-Induced Oxidative Injury in Brain of Rat
    Derviş Özçelik, Hafize Uzun, Mustafa Nazıroğlu · 2012 · Biological Trace Element Research
  40. Maternal N-acetyl-cysteine (NAC) protects the rat fetal brain from inflammatory cytokine responses to lipopolysaccharide (LPS)
    Ron Beloosesky, Zeev Weiner, Yuval Ginsberg, Michael Glenn Ross · 2012 · The Journal of Maternal-Fetal & Neonatal Medicine
  41. Interaction of N-acetylcysteine and Cysteine in Human Plasma
    Kendra K. Radtke, Lisa D. Coles, Usha R. Mishra, Paul J. Orchard, Mary Holmay, James C. Cloyd · 2012 · Journal of Pharmaceutical Sciences
  42. Cadmium(ii) N-acetylcysteine complex formation in aqueous solution
    Farideh Jalilehvand, Zahra Amini, Karnjit S. Parmar, Eun Young Kang · 2011 · Dalton Transactions
  43. N-Acetylcysteine elicited increase in cytochrome c oxidase activity in mice synaptic mitochondria
    Marcos Martı́nez, Natividad Martínez-Banaclocha · 1999 · Brain Research
  44. N-Acetylcysteine enhances UV-mediated caspase-3 activation, fragmentation of E2F-4, and apoptosis in human C8161 melanoma: inhibition by ectopic Bcl-2 expression
    Manuel Rieber, Manuel Rieber, Mary Strasberg Rieber · 2003 · Biochemical Pharmacology
  45. Distribution of Radio-Labeled N -Acetyl- L -Cysteine in Sprague-Dawley Rats and Its Effect on Glutathione Metabolism Following Single and Repeat Dosing by Oral Gavage
    Darryl P. Arfsten, Eric W. Johnson, Erin R. Wilfong, Anne E Jung, Andrew J. Bobb · 2007 · Cutaneous and Ocular Toxicology
  46. N-Acetylcysteine Potentiates Nitroglycerin-Induced Reversal of Platelet Aggregation
    Yuliy Y. Chirkov, John David Horowitz · 1996 · Journal of Cardiovascular Pharmacology
  47. Reactive oxygen species alter autocrine and paracrine signaling
    Richard C. Zangar, Nikki Bollinger, Thomas J. Weber, Ruimin Tan, Lye Meng Markillie, Norman J. Karin · 2011 · Free Radical Biology and Medicine
  48. The antioxidant N-acetyl-cysteine protects cultured epithelial cells from menadione-induced cytopathology
    Walter Malorni, Roberto Rivabene, Paola Matarrese · 1995 · Chemico-Biological Interactions
  49. Neuroprotective effect of N‐acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: Involvement of ERK and p38 phosphorylation
    Chia‐Ho Lin, Sheng‐Chu Kuo, Li‐Jiau Huang · 2006 · Journal of Neuroscience Research
  50. The effect of N‐acetylcysteine on amphetamine‐mediated dopamine release in rat brain striatal slices by ion‐pair reversed‐phase high performance liquid chromatography
    E. Gere‐Pászti, Judit Jakus · 2009 · Biomedical Chromatography
  51. Differential effects of thiols on DNA modifications via alkylation and Michael addition by .alpha.-acetoxy-N-nitrosopyrrolidine
    Mingyao Wang, Akiyoshi Nishikawa, Fung Lung Chung · 1992 · Chemical Research in Toxicology
  52. Inhibition of doxorubicin-initiated membrane damage by N-acetylcysteine: Possible mediation by a thiol-dependent, cytosolic inhibitor of lipid peroxidation
    Saul R. Powell, Paul B. McCay · 1988 · Toxicology and Applied Pharmacology
  53. The Effects of N‐Acetylcysteine and Deferoxamine on Plasma Cytokine and Oxidative Damage Parameters in Critically Ill Patients With Prolonged Hypotension: A Randomized Controlled Trial
    Cassiana Mazon Fraga, Cristiane Damiani Tomasi, Daiane Biff, Maria Fernanda Locks Topanotti, Francine Felisberto, Francieli Silva Vuolo, Fabricia Cardoso Petronilho, Felipe Dal‐Pizzol, Cristiane Ritter · 2011 · The Journal of Clinical Pharmacology
  54. Augmentation of human neutrophil and alveolar macrophage LTB4 production by N‐acetylcysteine: role of hydrogen peroxide
    Gordon Dent, Klaus Friedrich Rabe, HELGO MAGNUSSEN · 1997 · British Journal of Pharmacology
  55. N-acetylcysteine enhances receptor-mediated phagocytosis by human neutrophils.
    L Ohman, Cláes Dahlgren, Per Follin · 1992 · PubMed
  56. Reversible Change in Thiol Redox Status of the Insulin Receptor α-Subunit in Intact Cells
    Michael J. Garant, Sutapa Kole, Elena M. Maksimova · 1999 · Biochemistry
  57. N-Acetylcysteine enhances production of dopaminergic neurons from mesencephalic-derived precursor cells
    Jannette Rodríguez‐Pallares, Pablo Rey, Ramón Soto‐Otero, José Luis Labandeira-García · 2001 · Neuroreport
  58. Free energy relationships for thiol-disulfide interchange reactions between charged molecules in 50% methanol.
    Grayson H. Snyder · 1984 · Journal of Biological Chemistry
  59. Paraquat-Induced Formation of Leukotriene B4 in Rat Lungs: Modulation by N-Acetylcysteine
    Erica Hoffer, Larissa Shenker, Yelena Baum · 1997 · Free Radical Biology and Medicine
  60. N-acetylcysteine inhibits the induction of an antigen-specific antibody response down-regulating CD40 and CD27 co-stimulatory molecules
    Luciana Giordani, Maria Giovanna Quaranta, Walter Malorni · 2002 · Clinical & Experimental Immunology
  61. N‐acetyl‐cysteine enhances cell adhesion properties of epithelial and lymphoid cells.
    Roberto Rivabene, Marina Viora, Paola Matarrese, Gabriella Rainaldi, Antonella D’Ambrosio, Walter Malorni · 1995 · Cell Biology International
  62. Cadmium binding by biological ligands. 2 [1]. Formation of protonated and polynuclear complexes between cadmium and 2-mercaptoethylamine
    Alex Avdeef, Jessica A. Brown · 1984 · Inorganica Chimica Acta
  63. N-acetylcysteine prevents the doxorubicin-induced decrease of cyclic GMP.
    Donald V. Unverferth, Richard H. Fertel, S P Balcerzak · 1983 · PubMed
  64. Mechanisms of matrix metalloproteinase-9 and matrix metalloproteinase-2 inhibition by N-acetylcysteine in the human term decidua and fetal membranes
    Amir Weiss, Shlomit Goldman, Izhar Ben‐Shlomo, Vered Eyali, Shamir Leibovitz, Eliezer Shalev · 2003 · American Journal of Obstetrics and Gynecology