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Cited by 203Mitochondrial Function and PathologyDNA Repair MechanismsAutophagy in Disease and Therapy

Mitochondrial DNA damage and its consequences for mitochondrial gene expression

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Cline, Susan D.·2012·Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
DOI 10.1016/j.bbagrm.2012.06.002PMC PMC3412069
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Abstract

How mitochondria process DNA damage and whether a change in the steady-state level of mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction are questions that fuel burgeoning areas of research into aging and disease pathogenesis. Over the past decade, researchers have identified and measured various forms of endogenous and environmental mtDNA damage and have elucidated mtDNA repair pathways. Interestingly, mitochondria do not appear to contain the full range of DNA repair mechanisms that operate in the nucleus, although mtDNA contains types of damage that are targets of each nuclear DNA repair pathway. The reduced repair capacity may, in part, explain the high mutation frequency of the mitochondrial chromosome. Since mtDNA replication is dependent on transcription, mtDNA damage may alter mitochondrial gene expression at three levels: by causing DNA polymerase γ nucleotide incorporation errors leading to mutations, by interfering with the priming of mtDNA replication by the mitochondrial RNA polymerase, or by inducing transcriptional mutagenesis or premature transcript termination. This review summarizes our current knowledge of mtDNA damage, its repair, and its effects on mtDNA integrity and gene expression. This article is part of a special issue entitled: Mitochondrial Gene Expression.

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Authors
Cline, S. D.
Affiliations
Mercer University (US)
Corresponding author
Cline, Susan D.
ORCID
Cline, Susan D.
Venue
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Publisher
Elsevier BV
Published
2012-09
Volume
1819
Issue
9-10
Pages
979-991
ISSN
1874-9399 (ISSN-L)
DOI
10.1016/j.bbagrm.2012.06.002
PMC
PMC3412069
OpenAlex
W2004616200
Cited by
203
References
246
Citations by year
2026: 12 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 24 · 2019: 15 · 2018: 14 · 2017: 20 · 2016: 22 · 2015: 9 · 2014: 9 · 2013: 16 · 2012: 3
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIH/National Institute of General Medical Sciences (R15GM087681)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial DNA damage, mtDNA repair, mitochondrial gene expression, mitochondrial dysfunction, DNA polymerase gamma, mitochondrial DNA replication, mitochondrial RNA polymerase, transcriptional mutagenesis, aging
MeSH terms
DNA Polymerase gamma, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, DNA, Mitochondrial, Humans, Mitochondria, Oxidation-Reduction, Transcription, Genetic, Reactive Oxygen Species

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