Chromatin states at ribosomal DNA loci
Abstract
Eukaryotic transcription of ribosomal RNAs (rRNAs) by RNA polymerase I can account for more than half of the total cellular transcripts depending on organism and growth condition. To support this level of expression, eukaryotic rRNA genes are present in multiple copies. Interestingly, these genes co-exist in different chromatin states that may differ significantly in their nucleosome content and generally correlate well with transcriptional activity. Here we review how these chromatin states have been discovered and characterized focusing particularly on their structural protein components. The establishment and maintenance of rRNA gene chromatin states and their impact on rRNA synthesis are discussed. This article is part of a Special Issue entitled: Transcription by Odd Pols.
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Repressive histone modifications, DNA methylation and nucleosome remodeling are mechanisms responsible for rDNA silencing in yeast and mammalian cells.
“Repressive histone modifications, DNA methylation and nucleosome remodeling have been identified as the mechanisms responsible for rDNA silencing in studies performed mainly in yeast and mammalian cells (see (26–29) for reviews).”
From Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon (2022) · cites this paper as [27]
Cites
Life on a planet of its own: Regulation of RNA polymerase I transcription in the nucleolus
Grummt, I. (2003) · Genes & Development · doi:10.1101/gad.1098503r · Cited by 540 · see citing works
Integrative genomic analysis of human ribosomal DNA
Zentner, G. E., Saiakhova, A., Manaenkov, P., Adams, M. D., & Scacheri, P. C. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1326 · Cited by 165 · see citing works
Stancheva, I., Lucchini, R., Koller, T., & Sogo, J. M. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.9.1727 · Cited by 51 · see citing works
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Fefelova, E. A., Pleshakova, I. M., Mikhaleva, E. A., Pirogov, S. A., Poltorachenko, V. A., Abramov, Y. A., Romashin, D. D., Shatskikh, A. S., Blokh, R. S., Gvozdev, V. A., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1276 · Cited by 15 · see citing works
- Authors
- Hamperl, S., Wittner, M., Babl, V., Perez-Fernandez, J., Tschochner, H., & Griesenbeck, J.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Griesenbeck, Joachim
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 1829
- Issue
- 3-4
- Pages
- 405-417
- ISSN
- 1874-9399 (ISSN-L)
- OpenAlex
- W2049039063
- Cited by
- 69
- References
- 3
- Citations by year
- 2026: 1 · 2025: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 3 · 2014: 10 · 2013: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- ribosomal DNA, chromatin state, RNA polymerase I, rRNA transcription, ribosomal RNA synthesis, transcriptional activity
- MeSH terms
- Animals, Chromatin, DNA, Ribosomal, Humans, RNA Polymerase I, RNA, Ribosomal, Transcription, Genetic, Epigenesis, Genetic, Genetic Loci
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