Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases
Abstract
Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane.
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Conversion of DAG into PA generates a bioactive metabolite with multiple functions.
“In principle, conversion of DAG into PA also generates a bioactive metabolite with multiple functions [54–58].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [56]
PA can recruit and/or activate PIP5K and can locally influence membrane topology.
“PA can recruit and/or activate specific proteins such as PIP5K [55,56] and, with its cone-shaped geometry, PA can locally influence membrane topology and thus impact in membrane trafficking events [59].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [56]
Cites
Phosphatidic acid, a key intermediate in lipid metabolism
Athenstaedt, K., & Daum, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00822.x · Cited by 403 · see citing works
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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176 · see citing works
Self-citationDiacylglycerol kinases in T cell tolerance and effector function
Chen, S. S., Hu, Z., & Zhong, X.-P. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00130 · Cited by 44 · see citing works
- Authors
- Cockcroft, S.
- Affiliations
- University College London (GB)
- Corresponding author
- Cockcroft, Shamshad
- ORCID
- Cockcroft, Shamshad
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 1791
- Issue
- 9
- Pages
- 905-912
- ISSN
- 1388-1981 (ISSN-L)
- OpenAlex
- W2067400865
- Cited by
- 64
- References
- 1
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 10 · 2012: 4
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Cancer Research UK
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- phosphatidic acid, phosphatidylinositol 4-phosphate 5-kinase, phospholipase D, Arf proteins, second messengers, enzyme activation, plasma membrane, lipid signaling
- MeSH terms
- Amino Acid Sequence, Animals, Enzyme Activation, Humans, Molecular Sequence Data, Phosphatidic Acids, Phospholipase D, Phosphotransferases (Alcohol Group Acceptor), ADP-Ribosylation Factors, Amino Acids, Basic
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