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Cited by 312Ion channel regulation and functionCellular transport and secretionLipid Membrane Structure and Behavior

Phosphoinositides regulate ion channels

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Hille, Bertil, Dickson, Eamonn J., Kruse, Martin, Vivas, Oscar, Suh, Byung-Chang·2015·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2014.09.010PMC PMC4364932
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Abstract

Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides.

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Authors
Hille, B., Dickson, E. J., Kruse, M., Vivas, O., & Suh, B.-C.
Affiliations
  • University of Washington (US)
  • Daegu Gyeongbuk Institute of Science and Technology (KR)
Corresponding author
Hille, Bertil
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2015-06
Volume
1851
Issue
6
Pages
844-856
ISSN
1388-1981 (ISSN-L)
DOI
10.1016/j.bbalip.2014.09.010
PMC
PMC4364932
OpenAlex
W1979196237
Cited by
312
References
145
Citations by year
2026: 8 · 2025: 17 · 2024: 23 · 2023: 28 · 2022: 23 · 2021: 27 · 2020: 34 · 2019: 37 · 2018: 40 · 2017: 26 · 2016: 29 · 2015: 20
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (R37NS08174)
  • Ministry of Education, Science and Technology (2012R1A1A2044699)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords
phosphoinositides, ion channels, phosphatidylinositol 4,5-bisphosphate, membrane lipid composition, electrical excitability, receptor signaling, channel trafficking, lipid second messengers
MeSH terms
Cell Membrane, Gene Expression Regulation, Humans, Type C Phospholipases, Calcium Channels, Potassium Channels, Signal Transduction, Ion Transport, Chloride Channels, Phosphatidylinositol 4,5-Diphosphate, Receptors, G-Protein-Coupled, Transient Receptor Potential Channels, Epithelial Sodium Channels

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