Control of mitochondrial permeability by Bcl-2 family members
Open accessAbstract
Programmed cell death (apoptosis) is regulated by the Bcl-2 family of proteins. Although it remains unclear how these family members control apoptosis, they clearly have the capacity to regulate the permeability of intracellular membranes to ions and proteins. Proapoptotic members of the Bcl-2 family, especially Bax and Bid, have been extensively analyzed for the ability to form channels in membranes and to regulate preexisting channels. Anti-apoptotic members of the family tend to have the opposing effects on membrane channel formation. The molecular mechanisms of the different models for the permeabilization of membranes by the Bcl-2 family members and the regulation of Bcl-2 family member subcellular localizations are discussed.
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Regulation of mitochondrial membrane depolarization, including LRRK2 and BCL2, was upregulated with increased β-amyloid.
“Interestingly, “regulation of mitochondrial membrane depolarization”, which included LRRK2 and BCL2 genes, both of which can regulate apoptotic cell death pathways, was upregulated with increased β-amyloid [64].”
From Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics (2024) · cites this paper as [64]
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References 72 · Cited by 367
- Authors
- Sharpe, J. C., Arnoult, D., & Youle, R. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Youle, Richard J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 1644
- Issue
- 2-3
- Pages
- 107-113
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2100185604
- Cited by
- 367
- References
- 72
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 12 · 2023: 9 · 2022: 4 · 2021: 14 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 11 · 2013: 13 · 2012: 17
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- Bcl-2 family proteins, mitochondrial permeability, apoptosis, Bax, Bid, membrane permeabilization, ion channels, protein channels, subcellular localization, anti-apoptotic proteins, pro-apoptotic proteins
- MeSH terms
- Mitochondrial Permeability Transition Pore, Mitochondrial ADP, ATP Translocases, Animals, Carrier Proteins, Intracellular Membranes, Ion Channels, Membrane Lipids, Membrane Proteins, Mitochondria, Permeability, Proto-Oncogene Proteins, Porins, Proto-Oncogene Proteins c-bcl-2, Mitochondrial Membrane Transport Proteins, Voltage-Dependent Anion Channels, bcl-2 Homologous Antagonist-Killer Protein, BH3 Interacting Domain Death Agonist Protein, bcl-2-Associated X Protein
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