Peroxisomes and aging
Open accessAbstract
Peroxisomes are indispensable for proper functioning of human cells. They efficiently compartmentalize enzymes responsible for a number of metabolic processes, including the absolutely essential beta-oxidation of specific fatty acid chains. These and other oxidative reactions produce hydrogen peroxide, which is, in most instances, immediately processed in situ to water and oxygen. The responsible peroxidase is the heme-containing tetrameric enzyme, catalase. What has emerged in recent years is that there are circumstances in which the tightly regulated balance of hydrogen peroxide producing and degrading activities in peroxisomes is upset-leading to the net production and accumulation of hydrogen peroxide and downstream reactive oxygen species. The factor most essentially involved is catalase, which is missorted in aging, missing or present at reduced levels in certain disease states, and inactivated in response to exposure to specific xenobiotics. The overall goal of this review is to summarize the molecular events associated with the development and advancement of peroxisomal hypocatalasemia and to describe its effects on cells. In addition, results of recent efforts to increase levels of peroxisomal catalase and restore oxidative balance in cells will be discussed.
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Import efficiency is reduced in aged cells.
“It was shown that import efficiency is reduced in aged cells”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Terlecky et al., 2006
Reduced import efficiency in aged cells may disproportionately affect import of catalase relative to reactive oxygen species-producing enzymes, resulting in elevated oxidative stress.
“since catalase has a weak peroxisomal import signal, this may disproportionately affect import of catalase relative to reactive oxygen species-producing enzymes, resulting in elevated oxidative stress”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Terlecky et al., 2006
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References 44 · Cited by 138
Research works printed but not linked: 1
- Q. Chen, B.N. Ames, Senescent-like growth arrest induced by hydrogen peroxide in human diploid fibroblasts, Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 4130-4134.
- Authors
- Terlecky, S. R., Koepke, J. I., & Walton, P. A.
- Affiliations
- Wayne State University (US)
- Western University (CA)
- Corresponding author
- Terlecky, Stanley R.
- ORCID
- Terlecky, Stanley R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 1763
- Issue
- 12
- Pages
- 1749-1754
- ISSN
- 0167-4889 (ISSN-L)
- PMC
- PMC2997701
- OpenAlex
- W2114108892
- Cited by
- 138
- References
- 44
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 15 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 7 · 2012: 7
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056299)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- peroxisomes, aging, catalase, hydrogen peroxide, reactive oxygen species, oxidative stress, fatty acid beta-oxidation, prooxidant-antioxidant balance
- MeSH terms
- Peroxisome-Targeting Signal 1 Receptor, Aging, Catalase, Humans, Hydrogen Peroxide, Cellular Senescence, Receptors, Cytoplasmic and Nuclear, Acatalasia, Peroxisomes, Protein Transport
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