The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

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Items 101–200 of 504

1. Alternative approaches to Hsp90 modulation for the treatment of cancer
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2. Probing Molecular Mechanisms of the Hsp90 Chaperone: Biophysical Modeling Identifies Key Regulators of Functional Dynamics
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3. Inhibition of Heat Shock Protein 90 Prevents HIV Rebound
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4. Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
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5. Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques
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6. Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
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7. Expression of Heat Shock Protein (Hsp90) Paralogues Is Regulated by Amino Acids in Skeletal Muscle of Atlantic Salmon
   Daniel García de la serrana, Ian Alistair Johnston · 2013 · PLoS ONE
8. Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress
   Chun Yan Wang, Su Guo, Jia Yu Wang, Fen Liu, Yuan Yuan Zhang, Hamed Yari, Xu Guang Yan, Lei Jin, Xu Dong Zhang, Chen Chen Jiang · 2016 · Molecular Cancer Therapeutics
9. Following the design path of isoform-selective Hsp90 inhibitors: Small differences, great opportunities
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10. HOP family plays a major role in long‐term acquired thermotolerance in Arabidopsis
    Nuria Fernández‐Bautista, Lourdes Fernández‐Calvino, Alfonso Muñoz, René Toribio, Hans‐Peter Mock, M. Mar Castellano · 2018 · Plant Cell & Environment
11. Hsp90: From Cellular to Organismal Proteostasis
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12. The hormone-dependent function of Hsp90 in the crosstalk between 20-hydroxyecdysone and juvenile hormone signaling pathways in insects is determined by differential phosphorylation and protein interactions
    Wen Liu, Fengxia Zhang, Meijuan Cai, Wen-Li Zhao, Xiang-Ru Li, Jin‐Xing Wang, Xiao‐Fan Zhao · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
13. Structural and functional studies of Leishmania braziliensis Hsp90
    Kamila Parreira da Silva, Thiago Vargas Seraphim, Júlio C. Borges · 2012 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
14. Differential protein–protein interactions of LRRK 1 and LRRK 2 indicate roles in distinct cellular signaling pathways
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15. hERG quality control and the long QT syndrome
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16. Dissecting Structure-Encoded Determinants of Allosteric Cross-Talk between Post-Translational Modification Sites in the Hsp90 Chaperones
    Gabrielle Stetz, Amanda Tse, Gennady M. Verkhivker · 2018 · Scientific Reports
17. RING Finger Protein RNF207, a Novel Regulator of Cardiac Excitation
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18. A chemical compound inhibiting the Aha1–Hsp90 chaperone complex
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19. HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy
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20. Effects of acclimation temperature on the thermal physiology in two geographically distinct populations of lake sturgeon (Acipenser fulvescens)
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21. Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis
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22. Interaction of E. coli Hsp90 with DnaK Involves the DnaJ Binding Region of DnaK
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23. Dynamic Impacts of the Inhibition of the Molecular Chaperone Hsp90 on the T-Cell Proteome Have Implications for Anti-Cancer Therapy
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24. Substrate recognition and function of the R2TP complex in response to cellular stress
    Patrick von Morgen, Zuzana Hořejšı́, Libor Macůrek · 2015 · Frontiers in Genetics
25. Nox5 stability and superoxide production is regulated by C-terminal binding of Hsp90 and CO-chaperones
    Feng Chen, Steven Haigh, Yanfang Yu, Tyler W. Benson, Yusi Wang, Xueyi Li, Huijuan Dou, Zsolt A Bagi, Alexander D. Verin, David W. Stepp et al. · 2015 · Free Radical Biology and Medicine
26. Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors
    Mark R. Woodford, Diana M. Dunn, Jonelle B. Miller, Sami Jamal, Len Neckers, Mehdi Mollapour · 2015 · Advances in cancer research
27. X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition
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28. A switch point in the molecular chaperone Hsp90 responding to client interaction
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29. Hop/Sti1 phosphorylation inhibits its co‐chaperone function
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30. Extensive functional redundancy in the regulation of C andida albicans drug resistance and morphogenesis by lysine deacetylases H os2, H da1, R pd3 and R pd31
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31. Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells
    Katharina Ernst, Johannes Schmid, Matthias Beck, Marlen Hägele, Meike Hohwieler, Patricia Hauff, Anna‐Katharina Ückert, Anna Anastasia, Michael Fauler, Thomas Jank et al. · 2017 · Scientific Reports
32. Establishment of Dimethyl Labeling-based Quantitative Acetylproteomics in Arabidopsis
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33. Chaperome heterogeneity and its implications for cancer study and treatment
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34. Chaperones and chaperone–substrate complexes: Dynamic playgrounds for NMR spectroscopists
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35. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model
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36. Protein plasticity underlines activation and function of ATP-independent chaperones
    Ohad Suss, Dana Reichmann · 2015 · Frontiers in Molecular Biosciences
37. Chaperone families and interactions in metazoa
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38. The Bacterial Hsp90 Chaperone: Cellular Functions and Mechanism of Action
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39. Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches
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40. A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation
    Pablo C. Echeverría, Pierre-André Briand, Didier Picard · 2016 · Molecular and Cellular Biology
41. A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
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42. Differential Modulation of Functional Dynamics and Allosteric Interactions in the Hsp90-Cochaperone Complexes with p23 and Aha1: A Computational Study
    Kristin M. Blacklock, Gennady M. Verkhivker · 2013 · PLoS ONE
43. Allosteric Regulation of the Hsp90 Dynamics and Stability by Client Recruiter Cochaperones: Protein Structure Network Modeling
    Kristin M. Blacklock, Gennady M. Verkhivker · 2014 · PLoS ONE
44. Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation
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45. Extracellular HSP90 Machineries Build Tumor Microenvironment and Boost Cancer Progression
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46. Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia
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47. Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery
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48. hsp90 and hsp47 appear to play an important role in minnow Puntius sophore for surviving in the hot spring run-off aquatic ecosystem
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49. Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy
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50. Getting Folded: Chaperone Proteins in Muscle Development, Maintenance and Disease
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51. p53 Protein Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression
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52. Modulation of Molecular Chaperones in Huntington’s Disease and Other Polyglutamine Disorders
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53. Long Noncoding RNA CPS1-IT1 Suppresses Cell Proliferation and Metastasis in Human Lung Cancer
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54. Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation
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55. Transcriptome reveals the important role of metabolic imbalances, immune disorders and apoptosis in the treatment of Procambarus clarkii at super high temperature
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56. The penalty of stress ‐ Epichaperomes negatively reshaping the brain in neurodegenerative disorders
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57. The Co-Chaperone Hch1 Regulates Hsp90 Function Differently than Its Homologue Aha1 and Confers Sensitivity to Yeast to the Hsp90 Inhibitor NVP-AUY922
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58. Correctors Rescue CFTR Mutations in Nucleotide‐Binding Domain 1 (NBD1) by Modulating Proteostasis
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59. Investigating the underlying mechanism of Saccharomyces cerevisiae in response to ethanol stress employing RNA-seq analysis
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60. SGTA: A New Player in the Molecular Co-Chaperone Game
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61. Potent Antitrypanosomal Activities of Heat Shock Protein 90 Inhibitors In Vitro and In Vivo
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62. The Role of HSP90 Inhibitors in the Treatment of Cardiovascular Diseases
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63. Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation
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64. Isoform-Specific Phosphorylation in Human Hsp90β Affects Interaction with Clients and the Cochaperone Cdc37
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65. Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains
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66. Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue
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67. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone
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68. Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils
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69. AIPL1: A specialized chaperone for the phototransduction effector
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70. Methyl group assignment using pseudocontact shifts with PARAssign
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71. The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation
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72. HOP, a Co-chaperone Involved in Response to Stress in Plants
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73. The co-chaperone p23 controls root development through the modulation of auxin distribution in the Arabidopsis root meristem
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74. Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins
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75. Heat Shock Protein HSP24 Is Involved in the BABA-Induced Resistance to Fungal Pathogen in Postharvest Grapes Underlying an NPR1-Dependent Manner
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76. Comparative transcriptome analysis of differentially expressed genes and pathways in Procambarus clarkii (Louisiana crawfish) at different acute temperature stress
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77. Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone
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78. Transcriptome profiling of Issatchenkia orientalis under ethanol stress
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79. Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin
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80. The HSP40 family chaperone isoform DNAJB6b prevents neuronal cells from tau aggregation
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81. Antioxidant Systems and Vitagenes in Poultry Biology: Heat Shock Proteins
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83. Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates
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87. Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1
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89. Low Resolution Structural Studies Indicate that the Activator of Hsp90 ATPase 1 (Aha1) of Leishmania braziliensis Has an Elongated Shape Which Allows Its Interaction with Both N- and M-Domains of Hsp90
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99. Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives
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