Ferroportin-mediated iron transport: Expression and regulation
Open accessAbstract
The distinguishing feature between iron homeostasis in single versus multicellular organisms is the need for multicellular organisms to transfer iron from sites of absorption to sites of utilization and storage. Ferroportin is the only known iron exporter and ferroportin plays an essential role in the export of iron from cells to blood. Ferroportin can be regulated at many different levels including transcriptionally, post-transcriptionally, through mRNA stability and post-translationally, through protein turnover. Additionally, ferroportin may be regulated in both cell-dependent and cell-autonomous fashions. Regulation of ferroportin is critical for iron homeostasis as alterations in ferroportin may result in either iron deficiency or iron overload. This article is part of a Special Issue entitled: Cell Biology of Metals.
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Synthesis of FPN is transcriptionally regulated by cellular hypoxia, iron and heme concentrations, and inflammatory signaling.
“Synthesis of FPN is transcriptionally regulated by cellular hypoxia, iron and heme concentrations, and inflammatory signaling 6 .”
From Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms (2020) · cites this paper as [6]
Ferritin and ferroportin can be regulated through mRNA stability or post-translationally through protein turnover.
“Ferritin and ferroportin can be regulated through mRNA stability or post-translationally through protein turnover [85], [86].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [85]
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References 88 · Cited by 373
- Authors
- Ward, D. M., & Kaplan, J.
- Affiliations
- University of Utah (US)
- Corresponding author
- Kaplan, Jerry
- ORCID
- Ward, Diane M.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 1823
- Issue
- 9
- Pages
- 1426-1433
- ISSN
- 0167-4889 (ISSN-L)
- PMC
- PMC3718258
- OpenAlex
- W1972051185
- Cited by
- 373
- References
- 88
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 44 · 2023: 25 · 2022: 23 · 2021: 32 · 2020: 37 · 2019: 32 · 2018: 26 · 2017: 28 · 2016: 24 · 2015: 15 · 2014: 27 · 2013: 11 · 2012: 3
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (DK070947, R01DK070947)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- ferroportin, iron transport, iron homeostasis, iron export, gene expression regulation, post-transcriptional regulation, mRNA stability, protein turnover, iron deficiency, iron overload, multicellular organisms
- MeSH terms
- Ferroportin, Animals, Cations, Divalent, Ceruloplasmin, Homeostasis, Humans, Iron, Protein Processing, Post-Translational, Transcriptional Activation, Gene Expression, Ion Transport, Protein Structure, Tertiary, RNA Stability, Antimicrobial Cationic Peptides, Cation Transport Proteins, Hepcidins
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