Mammalian iron metabolism and its control by iron regulatory proteins
Open accessAbstract
Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the past decade, significant progress has been made in understanding how IRPs are regulated by iron-dependent and iron-independent mechanisms and the pathological consequences of IRP2 deficiency in mice. The identification of novel IREs involved in diverse cellular pathways has revealed that the IRP-IRE network extends to processes other than iron homeostasis. A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism. This article is part of a Special Issue entitled: Cell Biology of Metals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IRPs 1 and 2 are mechanisms to maintain cytosolic iron levels.
“One such mechanism to maintain cytosolic iron levels are the iron regulatory proteins (IRPs) 1 and 2 [5, 179, 195].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 219 · Cited by 493
Research works printed but not linked: 1
- [179]Meyron-Holtz EG Ghosh MC Iwai K LaVaute T Brazzolotto X Berger UV Land W Ollivierre-Wilson H Grinberg A Love P Rouault TA Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis EMBO J 23 2004 386 395 14726953 PMC1271751
- Authors
- Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A.
- Affiliations
- University of Utah (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- Leibold, Elizabeth A.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 1823
- Issue
- 9
- Pages
- 1468-1483
- ISSN
- 0167-4889 (ISSN-L)
- PMC
- PMC3675657
- OpenAlex
- W1974844038
- Cited by
- 493
- References
- 219
- Citations by year
- 2026: 27 · 2025: 27 · 2024: 30 · 2023: 33 · 2022: 30 · 2021: 48 · 2020: 47 · 2019: 36 · 2018: 41 · 2017: 36 · 2016: 26 · 2015: 27 · 2014: 48 · 2013: 35 · 2012: 2
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (GM45201, DK068602, DK089212, DK66600, T32DK007115, T32DK007665)
- USDA Hatch Project (WIS01324)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron homeostasis, iron regulatory proteins, iron regulatory protein 1, IRP2, iron-responsive element, mRNA untranslated regions, iron metabolism disorders, metal homeostasis
- MeSH terms
- Animals, Ferritins, Gene Expression Regulation, Homeostasis, Humans, Iron, Mammals, Receptors, Transferrin, Ion Transport, Mice, Knockout, Response Elements, Untranslated Regions, Iron Regulatory Protein 1, Iron Regulatory Protein 2, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
