Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

Lane, D.J.R., Merlot, A.M., Huang, M.L.-H., Bae, D.-H., Jansson, P.J., Sahni, S., Kalinowski, D.S., Richardson, D.R.·2015·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cited by (399)

Items 101–200 of 399

  1. A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence
    Bidyottam Mittra, Maria Fernanda Laranjeira‐Silva, Juliana Perrone Bezerra de Menezes, Jennifer Jensen, Vladimir Michailowsky, Norma Windsor Andrews · 2016 · PLoS Pathogens
  2. Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A
    Belén Fernández, Elena Fdez, Patricia Gómez‐Suaga, Fernando Gil, Isabel Molina-Villalba, Isidró Ferrer, Sandip Patel, Grant C. Churchill, Sabine Hilfiker · 2016 · Autophagy
  3. From Rust to Quantum Biology: The Role of Iron in Retina Physiopathology
    Émilie Picard, Alejandra Daruich, Jenny Youale, Yves Courtois, Francine Béhar‐Cohen · 2020 · Cells
  4. Mitochondrial Ferritin Deletion Exacerbates β‐Amyloid‐Induced Neurotoxicity in Mice
    Peina Wang, Qiong Wu, Wenyue Wu, Haiyan Li, Yuetong Guo, Peng Yu, Guofen Gao, Zhenhua Shi, Baolu Zhao, Yan‐Zhong Chang · 2017 · Oxidative Medicine and Cellular Longevity
  5. Rare anemias due to genetic iron metabolism defects
    Pierre Brissot, Delphine G. Bernard, Éolia Brissot, Olivier Loréal, Marie‐Bérengère Troadec · 2018 · Mutation Research/Reviews in Mutation Research
  6. Regulation of mitochondrial iron homeostasis by sideroflexin 2
    Ei Ei Mon, Fan‐Yan Wei, Raja Norazireen Raja Ahmad, Takahiro Yamamoto, Toshiro Moroishi, Kazuhito Tomizawa · 2018 · The Journal of Physiological Sciences
  7. Molybdenum and tungsten enzymes redox properties – A brief overview
    Cristina M. Cordas, José J. G. Moura · 2019 · Coordination Chemistry Reviews
  8. Glutaredoxins and iron-sulfur protein biogenesis at the interface of redox biology and iron metabolism
    Ulrich Mühlenhoff, Joseph J. Braymer, Stefan Christ, Nicole Rietzschel, Marta A. Uzarska, Benjamin D Weiler, Roland Lill · 2020 · Biological Chemistry
  9. In vitro reconstitution, functional dissection, and mutational analysis of metal ion transport by mitoferrin-1
    Eric T. Christenson, Austin S. Gallegos, Anirban Banerjee · 2018 · Journal of Biological Chemistry
  10. Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia
    Shannon Chiang, Danuta S. Kalinowski, Patric J. Jansson, Des Raymond Richardson, Michael L.H. Huang · 2017 · Neurochemistry International
  11. A facile colorimetric method for the quantification of labile iron pool and total iron in cells and tissue specimens
    Usama Abbasi, Srinivas Abbina, Arshdeep Gill, Vriti Bhagat, Jayachandran N. Kizhakkedathu · 2021 · Scientific Reports
  12. The interplay of iron, oxidative stress, and α-synuclein in Parkinson’s disease progression
    Yan Chen, Xixi Luo, Yukun Yin, Elizabeth Rosalind Thomas, Kezhi Liu, Wenjun Wang, Xiang Li · 2025 · Molecular Medicine
  13. Iron homeostasis
    Shanshan Guo, David Michael Frazer, Gregory Jon Anderson · 2016 · Current Opinion in Clinical Nutrition & Metabolic Care
  14. Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI
    Ferdinand Schweser, Jesper Hagemeier, Michael G. Dwyer, Niels Bergsland, Simon Hametner, Bianca Weinstock‐Guttman, Robert Zivadinov · 2020 · Human Brain Mapping
  15. 3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis
    Chenwen Shao, Yani Liu, Zhang‐Peng Chen, Yajuan Qin, Xueao Wang, Xueting Wang, Chao Yan, Hai‐Liang Zhu, Jing Zhao, Yong Qian · 2021 · Cell chemical biology
  16. Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice
    Zhenzhen Liu, Kang Han, Xuege Huo, Bingqi Yan, Mohan Gao, Xin Lv, Peng Yu, Guofen Gao, Yan‐Zhong Chang · 2020 · Life Sciences
  17. Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities
    Usama Abbasi, Srinivas Abbina, Arshdeep Gill, Lily E. Takuechi, Jayachandran N. Kizhakkedathu · 2021 · ACS Chemical Biology
  18. Erythrocyte Efferocytosis by the Arterial Wall Promotes Oxidation in Early-Stage Atheroma in Humans
    Sandrine Delbosc, Richard Bayles, Jamila Khallou‐Laschet, Véronique Ollivier, Benoît Ho‐Tin‐Noé, Ziad Touat, Catherine Deschildre, Marion Morvan, Liliane Louedec, Laurent Gouya et al. · 2017 · Frontiers in Cardiovascular Medicine
  19. Impact of ferroptosis on preeclampsia: A review
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  20. Keeping heart homeostasis in check through the balance of iron metabolism
    Driton Vela · 2019 · Acta Physiologica
  21. Iron Assimilation during Emerging Infections Caused by Opportunistic Fungi with emphasis on Mucorales and the Development of Antifungal Resistance
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  22. Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes
    Darius J.R. Lane, Dong-Hun Bae, A. Rosemary Siafakas, Yohan Suryo Rahmanto, Lina Al-Akra, Patric J. Jansson, Robert A. Casero, Des Raymond Richardson · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  23. Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease
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  24. Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration
    Laura Prieto Clemente, Malena Rabenau, Stephan Tang, Josefina Stanka, Eileen Cors, Jenny Stroh, Carsten Culmsee, Silvia von Karstedt · 2020 · Cells
  25. An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
    Riccardo Turchi, Raffaella Faraonio, Daniele Lettieri‐Barbato, Katia Aquilano · 2020 · Biomolecules
  26. Control of nutrient uptake by IRF4 orchestrates innate immune memory
    Endi K. Santosa, Hyunu Kim, Timo Rückert, Jean-Benoît Le Luduec, Aamna J. Abbasi, Claire K. Wingert, Lila Peters, Joe N. Frost, Katharine C. Hsu, Chiara Romagnani et al. · 2023 · Nature Immunology
  27. Acute and Chronic Iron Overloading Differentially Modulates the Expression of Cellular Iron-homeostatic Molecules in Normal Rat Kidney
    Bassem Refaat, Abdelghany H. Abdelghany, Mohammad Abubakar Basalamah, Mohamed El‐Boshy, Jawwad Ahmad, Shakir Idris · 2018 · Journal of Histochemistry & Cytochemistry
  28. Deferoxamine-induced high expression of TfR1 and DMT1 enhanced iron uptake in triple-negative breast cancer cells by activating IL-6/PI3K/AKT pathway
    Chunli Chen, Ping Liu, Xiaoyue Duan, Man Cheng, L. Xu · 2019 · OncoTargets and Therapy
  29. Current roles of metals in arming sonodynamic cancer therapy
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  30. A rhodamine-based novel turn on trivalent ions sensor
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  31. Sucrosomial® Iron Supplementation in Mice: Effects on Blood Parameters, Hepcidin, and Inflammation
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  32. Sodium molybdate inhibits the growth of ovarian cancer cells via inducing both ferroptosis and apoptosis
    Guoping Mao, Dedong Xin, Qian Wang, Dongmei Lai · 2022 · Free Radical Biology and Medicine
  33. Copper Exposure Induced Chicken Hepatotoxicity: Involvement of Ferroptosis Mediated by Lipid Peroxidation, Ferritinophagy, and Inhibition of FSP1-CoQ10 and Nrf2/SLC7A11/GPX4 Axis
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  34. Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α—Ve-Cadherin Pathway
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  35. Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies
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  36. Anthracycline-induced cardiotoxicity: An overview from cellular structural perspective
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  37. Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects
    Yan-Sheng Wu, Hao Li, K. Yue, Chao Jing, Yuan-Sheng Duan · 2025 · Molecular Cancer
  38. Iron Absorption: Molecular and Pathophysiological Aspects
    Margherita Correnti, Elena Gammella, Gaetano Cairo, Stefania Recalcati · 2024 · Metabolites
  39. Methoxyeugenol regulates the p53/p21 pathway and suppresses human endometrial cancer cell proliferation
    Bruna Pasqualotto Costa, Marcella Tornquist Nassr, Fernando Mendonça Diz, Krist Helen Antunes, Géssica Luana Antunes, Lucas Kich Grün, Florencia María Barbé‐Tuana, Fernanda Bordignon Nunes, Gisele Branchini, Jarbas Rodrigues de Oliveira · 2020 · Journal of Ethnopharmacology
  40. Mitochondrial biology and dysfunction in secondary mitochondrial disease
    Megan J. Baker, Jordan J. Crameri, David R. Thorburn, Ann E. Frazier, Diana Stojanovski · 2022 · Open Biology
  41. PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool
    Brandon Chen, Nupur Kanti Das, Indrani Talukder, Rashi Singhal, Cristina Castillo, Anthony C. Andren, Joseph Douglas Mancias, Costas Andreas Lyssiotis, Yatrik Madhukar Shah · 2023 · Journal of Biological Chemistry
  42. Spotlight on iron and ferroptosis: research progress in diabetic retinopathy
    Junlin Ouyang, Ling Zhou, Qing Wang · 2023 · Frontiers in Endocrinology
  43. Epigenomic regulation by labile iron
    Vladimir Camarena, Tyler C. Huff, Gaofeng Wang · 2021 · Free Radical Biology and Medicine
  44. In vitro assessment of bio-augmented minerals from peanut oil cakes fermented by Aspergillus oryzae through Caco-2 cells
    Pardeep Kumar Sadh, Prince Chawla, Latika Bhandari, Ravinder Kaushik, Joginder Singh Duhan · 2017 · Journal of Food Science and Technology
  45. Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome
    David Haschka, Chiara Volani, Ambra Stefani, Piotr Tymoszuk, Thomas Mitterling, Evi Holzknecht, Anna Heidbreder, Stefan Coassin, Zuzana Sumbalová, Markus Seifert et al. · 2018 · Movement Disorders
  46. Management of iron overload: lessons from transfusion-dependent hemoglobinopathies
    Thomas D. Coates · 2024 · Blood
  47. Adaptive Changes Allow Targeting of Ferroptosis for Glioma Treatment
    Renxuan Huang, Rui Dong, Nan Wang, Yichun He, Peining Zhu, Chong Wang, Beiwu Lan, Yufei Gao, Liankun Sun · 2021 · Cellular and Molecular Neurobiology
  48. Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers
    Dorianne Sant’Angelo, Géraldine Descamps, Valentin Lecomte, Dimitri Stanicki, Sébastien Penninckx, Tatiana Dragan, Dirk Van Gestel, Sophie Laurent, Fabrice Journé · 2025 · Pharmaceuticals
  49. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells
    Volodymyr Tryndyak, Iryna Kindrat, Kostiantyn Dreval, Mona I. Churchwell, Frederick A. Beland, Igor P. Pogribny · 2018 · Food and Chemical Toxicology
  50. New Perspectives on Iron Uptake in Eukaryotes
    Harry G. Sherman, Carolyn Jovanovic, Snow Stolnik, Keith H. R. Baronian, Alison J. Downard, Frankie James Rawson · 2018 · Frontiers in Molecular Biosciences
  51. Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions
    Hassan Mustafa Arif, Zhong‐Ming Qian, Rui Wang · 2021 · Antioxidants and Redox Signaling
  52. Iron participated in breast cancer chemoresistance by reinforcing IL-6 paracrine loop
    Jing Li, Kun He, Ping Liu, Lisa Xuemin Xu · 2016 · Biochemical and Biophysical Research Communications
  53. Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal‐of‐Entry
    Juan Ma, Ruibin Li, Yin Liu, Guangbo Qu, Jing L. Liu, Wenli Guo, Haoyang Song, Xinghong Li, Yajun Liu, Tian Xia et al. · 2017 · Small
  54. Visualizing Metal Content and Intracellular Distribution in Primary Hippocampal Neurons with Synchrotron X-Ray Fluorescence
    Robert A. Colvin, Qiaoling Jin, Barry Chi Hong Lai, Lech Kiedrowski · 2016 · PLoS ONE
  55. Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase
    Kavita Gaur, Sofia C. Pérez Otero, Josué A. Benjamín-Rivera, Israel Rodríguez, Sergio A. Loza-Rosas, Alexandra M. Vázquez-Salgado, Eman A. Akam, Liz Hernández-Matías, Rohit Kumar Sharma, Nahiara Alicea et al. · 2021 · JACS Au
  56. Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy
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  57. Iron Ion-Releasing Polypeptide Thermogel for Neuronal Differentiation of Mesenchymal Stem Cells
    Madhumita Patel, Hyun Jung Lee, Seungyi Son, Heeju Kim, Jinheung Kim, Byeongmoon Jeong · 2019 · Biomacromolecules
  58. Mitochondrial iron supply is required for the developmental pulse of ecdysone biosynthesis that initiates metamorphosis in Drosophila melanogaster
    José Vicente Llorens, Christoph Metzendorf, Fanis Missirlis, Maria Lind · 2015 · JBIC Journal of Biological Inorganic Chemistry
  59. Emerging field: O-GlcNAcylation in ferroptosis
    Hongshuo Zhang, Juan Zhang, Haojie Dong, Ying Kong, Youfei Guan · 2023 · Frontiers in Molecular Biosciences
  60. Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence
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  61. Iron Responsive Element-Mediated Responses to Iron Dyshomeostasis in Alzheimer’s Disease
    Nhi Hin, Morgan Newman, Stephen Pederson, Michael Lardelli · 2021 · Journal of Alzheimer s Disease
  62. Research progress on the mechanism of ferroptosis and its clinical application
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  63. Heme in Cardiovascular Diseases: A Ubiquitous Dangerous Molecule Worthy of Vigilance
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  64. Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion
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  65. Silencing of Iron and Heme-Related Genes Revealed a Paramount Role of Iron in the Physiology of the Hematophagous Vector Rhodnius prolixus
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  66. Loss of Ssq1 leads to mitochondrial dysfunction, activation of autophagy and cell cycle arrest due to iron overload triggered by mitochondrial iron–sulfur cluster assembly defects in Candida albicans
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  71. Differences in the frequency of genetic variants associated with iron imbalance among global populations
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