The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics
Open accessAbstract
The versatility of mitochondrial metabolism and its fine adjustments to specific physiological or pathological conditions regulate fundamental cell pathways, ranging from proliferation to apoptosis. In particular, Ca2+ signalling has emerged as a key player exploited by mitochondria to tune their activity according with cell demand. The functional interaction between mitochondria and endoplasmic reticulum (ER) deeply impacts on the correct mitochondrial Ca2+ signal, thus modulating cell bioenergetics and functionality. Indeed, Ca2+ released by the ER is taken up by mitochondria where, both in the intermembrane space and in the matrix, it regulates the activity of transporters, enzymes and proteins involved in organelles' metabolism. In this review, we will briefly summarize Ca2+-dependent mechanisms involved in the regulation of mitochondrial activity. Moreover, we will discuss some recent reports, in which alterations in mitochondrial Ca2+ signalling have been associated with specific pathological conditions, such as neurodegeneration and cancer.
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Self-citationThe Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism
Gherardi, G., Monticelli, H., Rizzuto, R., & Mammucari, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.554904 · Cited by 109
Gomzikova, M. O., James, V., & Rizvanov, A. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.653322 · Cited by 106
Calcium, Bioenergetics, and Parkinson’s Disease
Zampese, E., & Surmeier, D. J. (2020) · Cells · doi:10.3390/cells9092045 · Cited by 79
Metadata
- Authors
- Rossi, A., Pizzo, P., & Filadi, R.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 1866
- Issue
- 7
- Pages
- 1068-1078
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2898534233
- Cited by
- 489
- References
- 106
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rossi, A., Pizzo, P., & Filadi, R. (2019). Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2018.10.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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