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Cited by 105Iron Metabolism and DisordersTrace Elements in HealthPlant Micronutrient Interactions and Effects

Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones

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Philpott, Caroline C., Patel, Sarju J., Protchenko, Olga·2020·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
DOI 10.1016/j.bbamcr.2020.118830PMC PMC7484093
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Abstract

Iron-containing proteins rely on the incorporation of a set of iron cofactors for activity. The cofactors must be synthesized or assembled from raw materials located within the cell. The chemical nature of this pool of raw material - referred to as the labile iron pool - has become clearer with the identification of micro- and macro-molecules that coordinate iron within the cell. These molecules function as a buffer system for the management of intracellular iron and are the focus of this review, with emphasis on the major iron chaperone protein coordinating the labile iron pool: poly C-binding protein 1.

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  • In mammals, GSH-Fe2+ complexes interact with iron chaperones (PCBP proteins) important for the distribution of iron to storage proteins, nonheme iron enzymes, and the ferroportin iron exporter.

    “For example, in mammals GSH-Fe2+ complexes interact with iron chaperones (PCBP proteins) important for the distribution of iron to storage proteins (ferritin), nonheme iron enzymes, and the ferroportin (Fpn1) iron exporter.144”

    From Metals in Motion: Understanding Labile Metal Pools in Bacteria (2025) · cites this paper as [144]

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Cited by

Sorted by citations

Authors
Philpott, C. C., Patel, S. J., & Protchenko, O.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Publisher
Elsevier BV
Published
2020-11
Volume
1867
Issue
11
Pages
118830
ISSN
0167-4889 (ISSN-L)
DOI
10.1016/j.bbamcr.2020.118830
PMC
PMC7484093
OpenAlex
W3081077178
Cited by
105
References
2
Citations by year
2026: 15 · 2025: 25 · 2024: 15 · 2023: 21 · 2022: 16 · 2021: 10 · 2020: 3
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Keywords
labile iron pool, iron chaperone, PCBP1, iron cofactor, iron-containing proteins, iron coordination
MeSH terms
Ferroptosis, Cytosol, DNA-Binding Proteins, Fatty Liver, Glutathione, Humans, Iron, Iron-Sulfur Proteins, RNA-Binding Proteins, Molecular Chaperones

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