The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Molecular mechanisms of stress granule assembly and disassembly
Open accessAbstract
Stress granules (SGs) are membrane-less ribonucleoprotein-based cellular compartments that form in the cytoplasm of a cell upon exposure to various environmental stressors. SGs contain a large set of proteins, as well as mRNAs that have been stalled in translation as a result of stress-induced polysome disassembly. Despite the fact that SGs have been extensively studied for many years, their function is still not clear. They presumably help the cell to cope with the encountered stress, and facilitate the recovery process after stress removal, upon which SGs disassemble. Aberrant formation of SGs and impaired SG disassembly majorly contributes to various pathological phenomena in cancer, viral infections, and neurodegeneration. The assembly of SGs is largely driven by liquid-liquid phase separation (LLPS), however the molecular mechanisms behind that are not fully understood. Recent studies have proposed a novel mechanism for SG formation that involves the interplay of a large interaction network of mRNAs and proteins. Here we review this novel concept for the assembly of SGs, and discuss the current insights into SG disassembly.
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Cites
1 retracted
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Cited by
Temporal control of the integrated stress response by a stochastic molecular switch
Klein, P., Kallenberger, S. M., Roth, H., Roth, K., Ly-Hartig, T. B. N., Magg, V., Aleš, J., Talemi, S. R., Qiang, Y., Wolf, S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk2022 · Cited by 50
(2025) · doi:10.1038/s41557-025-01847-3 · Cited by 40
Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state
(2022) · doi:10.1016/j.jmb.2022.167801 · Cited by 29
Metadata
- Authors
- Hofmann, S., Kedersha, N., Anderson, P., & Ivanov, P.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 1868
- Issue
- 1
- Pages
- 118876
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W3089848576
- Cited by
- 389
- References
- 155
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hofmann, S., Kedersha, N., Anderson, P., & Ivanov, P. (2021). Molecular mechanisms of stress granule assembly and disassembly. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. https://doi.org/10.1016/j.bbamcr.2020.118876
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