Amphibian antimicrobial peptides and Protozoa: Lessons from parasites
Open accessAbstract
Antimicrobial peptides (AMPs) from amphibians and other eukaryotes recognize pathogenicity patterns mostly related to differences in membrane composition between the host and a variety of bacterial, fungal and protozoan pathogens. Compared to the other two groups, protozoa are fairly neglected targets in antimicrobial chemotherapy, despite their role as causative agents for scourges such as malaria, amoebiasis, Chagas' disease or leishmaniasis. Herein we review the scarce but growing body of knowledge addressing the use of amphibian AMPs on parasitic protozoa, the adaptations of the protozoan to AMP pressure and their impact on AMP efficacy and specificity, and the current and foreseeable strategies for developing AMPs into practical therapeutic alternatives against parasitic disease.
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Some antimicrobial peptides have been shown to be broad-spectrum antibacterial, antifungal or antiprotozoal agents for which pathogens have a limited capability to develop resistance.
“Some of these molecules have been shown to be broad-spectrum antibacterial, antifungal or antiprotozoal agents for which pathogens have a limited capability to develop resistance [76,77].”
From Biofuels from algae: Challenges and potential (2010) · cites this paper as [77]
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References 151 · Cited by 121
- Authors
- Rivas, L., Luque-Ortega, J. R., & Andreu, D.
- Affiliations
- Universitat Pompeu Fabra (ES)
- ORCID
- Andreu, David
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 1788
- Issue
- 8
- Pages
- 1570-1581
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2010215490
- Cited by
- 121
- References
- 151
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 13 · 2017: 8 · 2016: 3 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Consejo Superior de Investigaciones Científicas
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- antimicrobial peptides, amphibian antimicrobial peptides, protozoan parasites, membrane composition, host-pathogen interaction, malaria, amoebiasis, Chagas disease, leishmaniasis, antiparasitic drug development, peptide specificity
- MeSH terms
- Amino Acid Sequence, Animals, Antiprotozoal Agents, Molecular Sequence Data, Phospholipids, Structure-Activity Relationship, Glycocalyx, Antimicrobial Cationic Peptides, Amphibian Proteins, Eukaryota
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