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Influenza M2 proton channels
Open accessAbstract
M2 of the influenza virus is an intriguing transmembrane protein that forms a minuscule proton channel in the viral envelope. Its recognized function is to equilibrate pH across the viral membrane during cell entry and across the trans-Golgi membrane of infected cells during viral maturation. It is vital for viral replication and it is a target for the anti-influenza drugs, amantadine and rimantadine. Recently, high resolution structures of M2 channels of both flu A and B have been obtained, providing the desperately needed structural details for understanding the mechanism of proton conductance. In particular, the establishment of the functional solution NMR system of the proton channels enabled simultaneous high resolution structure characterization and measurement of channel dynamics coupled to channel activity. This review summarizes our current understanding of how protons are conducted through the M2 channel from a structural point of view, as well as the modes by which important channel gating elements function during proton conduction.
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Cites
A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants
Harbury, P. B., Zhang, T., Kim, P. S., & Alber, T. (1993) · Science · doi:10.1126/science.8248779 · Cited by 1,490 · cited 1×
“This arrangement for coiled-coil assembly in membrane is an inverse of the water-soluble coiledcoil tetramers, in which positions a and d are typically hydrophobic residues and positions g and e are polar residues [37].”
Cited by
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Wanka, L., Iqbal, K., & Schreiner, P. R. (2013) · Chemical Reviews · doi:10.1021/cr100264t · Cited by 696
Zheng, M., & Kanneganti, T. (2020) · Immunological Reviews · doi:10.1111/imr.12909 · Cited by 586
A topological approach for protein classification
Cang, Z., Mu, L., Wu, K., Opron, K., Xia, K., & Wei, G.-W. (2015) · Computational and Mathematical Biophysics · doi:10.1515/mlbmb-2015-0009 · Cited by 93
Metadata
- Authors
- Pielak, R. M., & Chou, J. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 1808
- Issue
- 2
- Pages
- 522-529
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2085314725
- Cited by
- 203
- References
- 1
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pielak, R. M., & Chou, J. J. (2011). Influenza M2 proton channels. Biochimica et Biophysica Acta (BBA) - Biomembranes. https://doi.org/10.1016/j.bbamem.2010.04.015
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