The Interaction of Antipsychotic Drugs with Lipids and Subsequent Lipid Reorganization Investigated Using Biophysical Methods
Open accessAbstract
The interaction of antipsychotic drugs (AP) with lipids and the subsequent lipid reorganization on model membranes was assessed using a combination of several complementary biophysical approaches (calorimetry, plasmon resonance, fluorescence microscopy, X-ray diffraction and molecular modeling). The effect of haloperidol (HAL), risperidone (RIS), and 9-OH-risperidone (9-OH-RIS) was examined on single lipid and mixtures comprising lipids of biological origin. All APs interact with lipids and induced membrane reorganization. APs showed higher affinity for sphingomyelin than for phosphatidylcholine. Cholesterol increased AP affinity for the lipid bilayer and led to the following AP ranking regarding affinity and structural changes: RIS >9-OH-RIS >HAL. Liquid-ordered domain formation and bilayer thickness were differentially altered by AP addition. Docking calculations helped understanding the observed differences between the APs and offer a representation of their conformation in the lipid bilayer. Present results indicate that AP drugs may change membrane compartmentalization which could differentially modulate the signaling cascade of the dopamine D2 receptor for which APs are ligands.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Antipsychotics can modify D2 receptor activity by altering the lipid environment of the receptor.
“Studies performed on single lipids and mixtures consisting of lipids of biological origin demonstrated that antipsychotics can also modify D2 receptor activity by altering the lipid environment of the receptor [138].”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 53 · Cited by 40
- Authors
- Alves, I., Staneva, G., Tessier, C., Salgado, G. F., & Nuss, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Bulgarian Academy of Sciences (BG)
- Inserm (FR)
- Corresponding author
- Nuss, Philippe
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 1808
- Issue
- 8
- Pages
- 2009-2018
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W1987792440
- Cited by
- 40
- References
- 53
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2012: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 717 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Social Fund
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- antipsychotic drugs, drug-lipid interactions, lipid reorganization, model membranes, haloperidol, risperidone, sphingomyelin, phosphatidylcholine, cholesterol, liquid-ordered domains, bilayer thickness, membrane compartmentalization, molecular docking
- MeSH terms
- Paliperidone Palmitate, Calorimetry, Differential Scanning, Cell Membrane, Cholesterol, Haloperidol, Isoxazoles, Membrane Lipids, Membranes, Artificial, Microscopy, Fluorescence, Models, Molecular, Molecular Conformation, Phosphatidylcholines, Pyrimidines, Sphingomyelins, Structure-Activity Relationship, Antipsychotic Agents, X-Ray Diffraction, 1,2-Dipalmitoylphosphatidylcholine, Molecular Structure, Receptors, Dopamine D2, Dopamine Antagonists, Risperidone, Surface Plasmon Resonance, Dopamine D2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
