Cited by 563Metal-Catalyzed Oxygenation MechanismsGlutathione Transferases and PolymorphismsEnzyme Structure and Function

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Superoxide dismutases—a review of the metal-associated mechanistic variations

Abreu, Isabel A., Cabelli, Diane E.·2010·Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI 10.1016/j.bbapap.2009.11.005

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Abstract

Superoxide dismutases are enzymes that function to catalytically convert superoxide radical to oxygen and hydrogen peroxide. These enzymes carry out catalysis at near diffusion controlled rate constants via a general mechanism that involves the sequential reduction and oxidation of the metal center, with the concomitant oxidation and reduction of superoxide radicals. That the catalytically active metal can be copper, iron, manganese or, recently, nickel is one of the fascinating features of this class of enzymes. In this review, we describe these enzymes in terms of the details of their catalytic properties, with an emphasis on the mechanistic differences between the enzymes. The focus here will be concentrated mainly on two of these enzymes, copper, zinc superoxide dismutase and manganese superoxide dismutase, and some relatively subtle variations in the mechanisms by which they function.

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Authors: Abreu, I. A., & Cabelli, D. E.
Affiliations: Universidade Nova de Lisboa (PT)
Brookhaven National Laboratory (US)
Corresponding author: Cabelli, Diane E.
ORCID: Abreu, Isabel A.
Venue: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Publisher: Elsevier BV
Published: 2010-02
Volume: 1804
Issue: 2
Pages: 263-274
ISSN: 1570-9639 (ISSN-L)
DOI: 10.1016/j.bbapap.2009.11.005
OpenAlex: W2028661305
Cited by: 563
References: 99
Citations by year: 2026: 26 · 2025: 44 · 2024: 31 · 2023: 41 · 2022: 47 · 2021: 60 · 2020: 34 · 2019: 38 · 2018: 35 · 2017: 43 · 2016: 43 · 2015: 26 · 2014: 30 · 2013: 19 · 2012: 20
FWCI: 0.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (publishedVersion)
PubMed (publishedVersion)
Funders: Fundação para a Ciência e a Tecnologia
Topics: Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: superoxide dismutase, copper-zinc superoxide dismutase, manganese superoxide dismutase, enzyme mechanism, metalloenzyme catalysis, superoxide, hydrogen peroxide production, copper, iron, manganese, nickel, diffusion-controlled rate constants
MeSH terms: Animals, Copper, Humans, Iron, Manganese, Superoxide Dismutase, Zinc, Biocatalysis

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Superoxide dismutases—a review of the metal-associated mechanistic variations

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