Cysteine cathepsins: From structure, function and regulation to new frontiers

Turk, Vito, Stoka, Veronika, Vasiljeva, Olga, Renko, Miha, Sun, Tao, Turk, Boris, Turk, Dušan·2012·Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
DOI 10.1016/j.bbapap.2011.10.002

Cites (368)

Items 201–368 of 368

  1. Essential Role of Proline Isomerization in Stefin B Tetramer Formation
    S. Jenko Kokalj, Gregor Gunčar, Igor Štern, Gareth J. Morgan, Sabina Rabzelj, Manca Kenig, Rosemary A. Staniforth, Jonathan P. Waltho, Eva Žerovnik, Vito Türk · 2006 · Journal of Molecular Biology
  2. Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
    Paul Lindahl, Magnus Abrahamson, Ingemar Björk · 1992 · Biochemical Journal
  3. Characterization of the Type‐1 Repeat from Thyroglobulin, a Cysteine‐Rich Module Found in Proteins from Different Families
    Franck Molina, Majida Bouanani, Bernard Pau, Claude Granier · 1996 · European Journal of Biochemistry
  4. uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV
    Lars Kjøller, Lars Henning Engelholm, Maria Helena Høyer-Hansen · 2003 · Experimental Cell Research
  5. Lysosomal Cysteine Proteases: Structural Features and their Role in Apoptosis
    Veronika Stoka, Boris Turk, Vito Türk · 2005 · IUBMB Life
  6. RGD-dependent Binding of Procathepsin X to Integrin αvβ3 Mediates Cell-adhesive Properties
    Annette M. Lechner, Irmgard Assfalg‐Machleidt, Stefan Zahler A, Mechthild Stoeckelhuber, Werner Machleidt, Marianne Jochum, Dorit K. Nägler · 2006 · Journal of Biological Chemistry
  7. The Crystal and Molecular Structures of a Cathepsin K:Chondroitin Sulfate Complex
    Zhenqiang Li, Martin Kienetz, Maia M. Cherney, Michael N.G. James, Dieter Brömme · 2008 · Journal of Molecular Biology
  8. Calpain inhibition by peptide epoxides
    C Parkes, A A Kembhavi, A. John Barrett · 1985 · Biochemical Journal
  9. Selective Cysteine Protease Inhibition Contributes to Blood-feeding Success of the Tick Ixodes scapularis
    Michail Kotsyfakis, Shahid Karim, John F. Andersen · 2007 · Journal of Biological Chemistry
  10. Inhibition Mechanism of Cathepsin L-Specific Inhibitors Based on the Crystal Structure of Papain–CLIK148 Complex
    Hideaki Tsuge, Tomohiro Nishimura, Yukio Tada · 1999 · Biochemical and Biophysical Research Communications
  11. Glycosaminoglycans Facilitate Procathepsin B Activation through Disruption of Propeptide-Mature Enzyme Interactions
    Dejan Caglič, Jerica Rozman Pungerčar, Gunnar Pejler · 2007 · Journal of Biological Chemistry
  12. Kininogens: More than cysteine protease inhibitors and kinin precursors
    Gilles Lalmanach, Clément Naudin, Fabien Lecaille, Hans Fritz · 2010 · Biochimie
  13. Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation
    Nadia Naour, Christine Rouault, Soraya Fellahi, Marie-Ève Lavoie, Christine Poitou, Mayoura Kéophiphath, Delphine Eberlé, Steven E. Shoelson, Salwa W. Rizkalla, Jean‐Philippe Bastard et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
  14. Human cathepsin X: A novel cysteine protease of the papain family with a very short proregion and unique insertions1
    Dorit K. Nägler, Robert Ménard · 1998 · FEBS Letters
  15. Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
    Tamara T. Lah, M Cercek, Andrej Blejec · 2000 · PubMed
  16. Potency and selectivity of inhibition of cathepsin K, L and S by their respective propeptides
    Jocelyne Guay, Jean‐Pierre Falgueyret, Axel Ducret · 2000 · European Journal of Biochemistry
  17. Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity
    Mirosław Cygler, John S. Mort · 1997 · Biochimie
  18. Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells.
    Raphaël Lemaire, Guillemette Huet, Farid Zerimech, Georges Grard, Christian Fontaine, Bernard Duquesnoy, René‐Marc Flipo · 1997 · Lara D. Veeken
  19. Stefin B Interacts with Histones and Cathepsin L in the Nucleus
    Slavko Čeru, Špela Konjar, Katarina Maher, Urška Repnik, Igor Križaj, Mojca Benčina, Miha Renko, Alain Nepveu, Eva Žerovnik, Boris Turk et al. · 2010 · Journal of Biological Chemistry
  20. Autocatalytic processing of procathepsin B is triggered by proenzyme activity
    Jerica Rozman Pungerčar, Dejan Caglič, Mohammed Sajid · 2008 · FEBS Journal
  21. Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B
    Simone S. Cotrin, Luciano Puzer, Wagner Alves de Souza Júdice, Luiz Juliano, Adriana K. Carmona, María A. Juliano · 2004 · Analytical Biochemistry
  22. Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes
    Hiroshi Kobayashi, Nobuhiko Moniwa, Motoi Sugimura · 1993 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  23. Peptidase inhibitors in the MEROPS database
    Neil David Rawlings · 2010 · Biochimie
  24. Inhibitory Fragment from the p41 Form of Invariant Chain Can Regulate Activity of Cysteine Cathepsins in Antigen Presentation
    Marko Miheliĕ, Andreja Doberšek, Gregor Gunčar · 2008 · Journal of Biological Chemistry
  25. Inactivation of human cystatin C and kininogen by human cathepsin D
    Brigita Lenar≷cic̆, Marta Krašovec, Anka Ritonja, Ísleifur Ólafsson, Vito Türk · 1991 · FEBS Letters
  26. pH-induced Conformational Transitions of the Propeptide of Human Cathepsin L
    Roman Jerala, Eva Žerovnik, Jurka Kidrič · 1998 · Journal of Biological Chemistry
  27. Hereditary cystatin C amyloid angiopathy
    Ísleifur Ólafsson, ANDERS O. GRUBB · 2000 · Amyloid
  28. Cleavage Site Specificity of Cathepsin K toward Cartilage Proteoglycans and Protease Complex Formation
    Wu-Shiun Hou, Z. Li, Frank H. Büttner · 2003 · Biological Chemistry
  29. Lysosomal Proteases Cathepsins D, B, H, L and Their Inhibitors Stefins A and B in Head and Neck Cancer
    J Kos, Alojz Šmid, Marta Krašovec · 1995 · Biological Chemistry Hoppe-Seyler
  30. Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.
    Sadiq Hasnain, T. Hirama, Carol P. Huber · 1993 · Journal of Biological Chemistry
  31. Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity.
    Dieter Brömme, Pierre R. Bonneau, Paule Lachance · 1994 · Journal of Biological Chemistry
  32. Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase
    Ivica Klemenčič, Adriana K. Carmona, Maria Helena S. Cezari, María A. Juliano, Luiz Juliano, Gregor Gunčar, Dušan Turk, Igor Križaj, Vito Türk, Boris Turk · 2000 · European Journal of Biochemistry
  33. Human Cathepsin B Is a Metastable Enzyme Stabilized by Specific Ionic Interactions Associated with the Active Site
    Boris Turk, Iztok Dolenc, Eva Žerovnik · 1994 · Biochemistry
  34. Inhibition of cruzipain, the major cysteine proteinase of the protozoan parasite, Trypanosoma cruzi, by proteinase inhibitors of the cystatin superfamily
    Veronika Stoka, Maria Nycander, Brigita Lenar≷cic̆ · 1995 · FEBS Letters
  35. Acidic pH as a physiological regulator of human cathepsin L activity
    Boris Turk, Iztok Dolenc, Brigita Lenar≷cic̆, Igor Križaj, Vito Türk, Joseph G. Bieth, Ingemar Björk · 1999 · European Journal of Biochemistry
  36. Identification of Selective, Nonpeptidic Nitrile Inhibitors of Cathepsin S Using the Substrate Activity Screening Method
    Andrew W. Patterson, Warren J. L. Wood, Michael J. Hornsby · 2006 · Journal of Medicinal Chemistry
  37. Phorbol Ester Activation of a Proteolytic Cascade Capable of Activating Latent Transforming Growth Factor-β
    Meng Guo, Patricia Mathieu, Bruce E. Linebaugh, Bonnie F. Sloane, John J. Reiners · 2002 · Journal of Biological Chemistry
  38. The Crystal Structure of Human Procathepsin K
    Judith M. LaLonde, Baoguang Zhao, Cheryl A. Janson · 1998 · Biochemistry
  39. Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine
    Jayaraman Sivaraman, Dorit K. Nägler, Rulin Zhang, Robert Menard, Miroslaw Cygler · 2000 · Journal of Molecular Biology
  40. Crystallographic refinement of the structure of actinidin at 1.7 Å resolution by fast Fourier least-squares methods
    Edward N. Baker, Eleanor Joy Dodson · 1980 · Acta Crystallographica Section A
  41. Genealogy of mammalian cysteine proteinase inhibitors
    Werner Müller‐Esterl, Hans Fritz, Josef Kellermann · 1985 · FEBS Letters
  42. Molecular genetics of the NCLs — status and perspectives
    Eija Siintola, Anna‐Elina Lehesjoki, Sara Mole · 2006 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  43. Bovine stefin C, a new member of the stefin family.
    Boris Turk, Igor Križaj, B. Kralj · 1993 · Journal of Biological Chemistry
  44. Molecular cloning and sequence analysis of human preprocathepsin C
    Alenka Pariš, Borut Štrukelj, Jože Pungerčar · 1995 · FEBS Letters
  45. Conformational Variability of Chicken Cystatin
    Richard Alan Engh, Thorsten Dieckmann, Wolfram Bode · 1993 · Journal of Molecular Biology
  46. A new subgroup of the family 2 cystatins
    Gail A. Cornwall, Nelson Hsia · 2003 · Molecular and Cellular Endocrinology
  47. Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs
    Christina Stoeckle, Cécile Gouttefangeas, Michael Hammer, Ekkehard Weber, Arthur Melms, Eva Tolosa · 2008 · Experimental Hematology
  48. The Inhibition of Cathepsin S by its Propeptide — Specificity and Mechanism of Action
    Gunter Maubach, Klaus Schilling, Winfried Rommerskirch · 1997 · European Journal of Biochemistry
  49. Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological Disease
    Chi‐Hui Tang, Je–Wook Lee, Michael G. Galvez, Liliane Robillard, Sara Mole, Harold A. Chapman · 2006 · Molecular and Cellular Biology
  50. Crystal structure of cathepsin X: a flip–flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease
    Gregor Gunčar, Ivica Klemenčič, Boris Turk, Vito Türk, Adriana K. Carmona, Luiz Juliano, Dušan Turk · 2000 · Structure
  51. Cystatin B: mutation detection, alternative splicing and expression in progressive myclonus epilepsy of Unverricht-Lundborg type (EPM1) patients
    Tarja H. Joensuu, Mervi Kuronen, Kirsi Alakurtti et al. · 2006 · European Journal of Human Genetics
  52. Hurpin Is a Selective Inhibitor of Lysosomal Cathepsin L and Protects Keratinocytes from Ultraviolet-Induced Apoptosis
    Thomas Welss, Jiuru Sun, James A. Irving, Rainer Blum, A. Ian Smith, James C. Whisstock, Robert Neil Pike, Anna H. von Mikecz, Thomas Ruzicka, Phillip Ian Bird et al. · 2003 · Biochemistry
  53. The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding Mode and Evolution of an Inhibitor Family
    Stephanie X. Wang, Kailash Chand Pandey, Júlio Scharfstein et al. · 2007 · Structure
  54. Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Human Cathepsin L and Their Inhibitory Effect on Bone Resorption
    Tsuneo Yasuma, Satoru Oi, Nobuo Choh · 1998 · Journal of Medicinal Chemistry
  55. Selective Activity‐Based Probes for Cysteine Cathepsins
    Anja Watzke, Gregor Kosec, Maik Kindermann, Volker Jeske, Hans Peter Nestler, Vito Türk, Boris Turk, K. Ulrich Wendt · 2007 · Angewandte Chemie International Edition
  56. Mechanisms of amyloid fibril formation – focus on domain‐swapping
    Eva Žerovnik, Veronika Stoka, Andreja Mirtič, Gregor Gunčar, Jože Grdadolnik, Rosemary A. Staniforth, Dušan Turk, Vito Türk · 2011 · FEBS Journal
  57. Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.
    László Polgár, C Csoma · 1987 · Journal of Biological Chemistry
  58. Cloning a synthetic gene for human stefin B and its expression in E. coli
    Roman Jerala, M. Trstenjak, Brigita Lenar≷cic̆ · 1988 · FEBS Letters
  59. Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma
    Maroulio Talieri, Sofia Papadopoulou, Andreas Scorilas, Dimitrios Xynopoulos, Niki Arnogianaki, George A. Plataniotis, Julia Yotis, Niki Agnanti · 2003 · Cancer Letters
  60. Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes
    Annika Rennenberg, Christine Lehmann, Anna Heitmann, Tina Witt, Guido Hansen, Krishna Nagarajan, Christina Deschermeier, Vito Türk, Rolf Hilgenfeld, Volker Theo Heussler · 2010 · PLoS Pathogens
  61. Crystal Structure of Human Cathepsin V,
    John R. Somoza, Hangjun Zhan, Krista K. Bowman, Lily Yu, Kyle D. Mortara, James T. Palmer, James Matthew Clark, Mary E. McGrath · 2000 · Biochemistry
  62. Inhibitory effects of antisense cathepsin B cDNA transfection on invasion and motility in a human osteosarcoma cell line.
    Sabine Krueger, Carsten Haeckel, Frank Buehling · 1999 · PubMed
  63. Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomes
    Yukio Nishimura, Takahiro Kawabata, Koji Furuno · 1989 · Archives of Biochemistry and Biophysics
  64. Conformational flexibility and allosteric regulation of cathepsin K
    Marko Novinec, Lidija Kovačič, Brigita Lenar≷cic̆ · 2010 · Biochemical Journal
  65. Cathepsin L increases invasion and migration of B16 melanoma
    Zhen Fan Yang, James L Cox · 2007 · Cancer Cell International
  66. Structural basis for the recognition and cleavage of histone H3 by cathepsin L
    Melanie A. Adams-Cioaba, Joanne C. Krupa, Chao Xu, John S. Mort, Jinrong Min · 2011 · Nature Communications
  67. The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators
    John R. Somoza, James T. Palmer, Joseph D. Ho · 2002 · Journal of Molecular Biology
  68. Cathepsins and their involvement in immune responses
    Sébastien Conus, Hans-Uwe Simon · 2010 · Swiss Medical Weekly
  69. Invasiveness of Transformed Human Breast Epithelial Cell Lines Is Related to Cathepsin B and Inhibited by Cysteine Proteinase Inhibitors
    Aleš Bervar, Irena Zajc, N. Sever · 2003 · Biological Chemistry
  70. Cystatins from filarial parasites: Evolution, adaptation and function in the host–parasite relationship
    William F. Gregory, Rick M. Maizels · 2007 · The International Journal of Biochemistry & Cell Biology
  71. Dipeptidyl nitrile inhibitors of Cathepsin L
    Nabil Asaad, Paul A. Bethel, Michelle Coulson, Jack E. Dawson, Susannah J. Ford, S. Gerhardt, Matthew Grist, Gordon A. Hamlin, Michael J. James, Emma V. Jones et al. · 2009 · Bioorganic & Medicinal Chemistry Letters
  72. Purification of the complex of cathepsin L and the MHC class II‐associated invariant chain fragment from human kidney
    Tadeja Ogrinc, Iztok Dolenc, Anka Ritonja · 1993 · FEBS Letters
  73. Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical Implications
    Gaetano Leto, Francesca Maria Tumminello, Giuseppe Pizzolanti, Giuseppe Montalto, Maurizio Soresi, Nicola Gebbia · 2009 · Oncology
  74. Cathepsins B, H and L in human breast carcinoma.
    Dušica Gabrijelčič, Branka Svetic, D. Spaic · 1992 · PubMed
  75. Quantifying Cathepsin S Activity in Antigen Presenting Cells Using a Novel Specific Substrate
    Nicolas Lützner, Hubert Kalbacher · 2008 · Journal of Biological Chemistry
  76. Structural dissection of the multidomain kininogens. Fine mapping of the target epitopes of antibodies interfering with their functional properties.
    J. Kaufmann, Martina Haasemann, Susanne Modrow · 1993 · Journal of Biological Chemistry
  77. Crystal structure of wild‐type human procathepsin K
    Jayaraman Sivaraman, Manon Lalumière, Robert Ménard · 1999 · Protein Science
  78. Collagenolytic Cathepsins of Rabbit Spleen: A Kinetic Analysis of Collagen Degradation and Inhibition by Chicken Cystatin
    Rose A. Maciewicz, David J. Etherington, Janko Kos, Vito Türk · 1987 · Collagen and Related Research
  79. Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft
    Miha Renko, Urška Požgan, Dušana Majera · 2010 · FEBS Journal
  80. Full-Length cDNA of Human Cathepsin F Predicts the Presence of a Cystatin Domain at the N-terminus of the Cysteine Protease Zymogen
    Dorit K. Nägler, Traian I. Sulea, Robert Ménard · 1999 · Biochemical and Biophysical Research Communications
  81. Comparative substrate specificity analysis of recombinant human cathepsin V and cathepsin L
    Luciano Puzer, Simone S. Cotrin, Márcio F.M. Alves · 2004 · Archives of Biochemistry and Biophysics
  82. The S2 subsites of cathepsins K and L and their contribution to collagen degradation
    Fabien Lecaille, Shafinaz F. Chowdhury, Enrico O. Purisima, Dieter Brömme, Gilles Lalmanach · 2007 · Protein Science
  83. Cysteine protease cathepsin X modulates immune response via activation of β2 integrins
    Nataša Obermajer, Urška Repnik, Zala Jevnikar · 2008 · Immunology
  84. S3 to S3' subsite specificity of recombinant human cathepsin K and development of selective internally quenched fluorescent substrates
    Márcio F.M. Alves, Luciano Puzer, Simone S. Cotrin · 2003 · Biochemical Journal
  85. Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: Effects on the invasive phenotype
    Sabine Krueger, Udo Kellner, Frank Buehling · 2001 · Cancer Gene Therapy
  86. Two decades of thyroglobulin type-1 domain research
    Marko Mihelič, Vito Türk · 2007 · Biological Chemistry
  87. Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations
    Alain Roussel, Josiane D. DE CARO, Sofiane Bezzine, Louis N. Gastinel, Alain M. De Caro, Frédéric Carrière, Sabine Leydier, Robert Verger, Christian Cambillau · 1998 · Proteins Structure Function and Bioinformatics
  88. Cathepsin X binds to cell surface heparan sulfate proteoglycans
    Fábio Dupart Nascimento, Cláudia C.A. Rizzi, Iseli L. Nantes · 2005 · Archives of Biochemistry and Biophysics
  89. Probing cathepsin K activity with a selective substrate spanning its active site
    Fabien Lecaille, Enrico Weidauer, María A. Juliano · 2003 · Biochemical Journal
  90. Binding Mode of CA074, a Specific Irreversible Inhibitor, to Bovine Cathepsin B as Determined by X-Ray Crystal Analysis of the Complex
    A. Yamamoto, Tadaoki Hara, Koji Tomoo, T. Ishida, T. Fujii, Y. Hata, Masahiro Murata, KOUICHI KITAMURA · 1997 · The Journal of Biochemistry
  91. Cystatins of Parasitic Organisms
    Christian Klotz, Thomas R. Ziegler, Emilia Daniłowicz-Luebert, Susanne Hartmann · 2011 · Advances in experimental medicine and biology
  92. Determination of Cathepsin B Expression May Offer Additional Prognostic Information for Ovarian Cancer Patients
    Andreas Scorilas, Stelios Fotiou, Evangelos Tsiambas · 2002 · Biological Chemistry
  93. Emerging role of cathepsin S in obesity and its associated diseases
    Soraya Taleb, Karine Clément · 2007 · Clinical Chemistry and Laboratory Medicine (CCLM)
  94. Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.
    Sadie A. Aznavoorian, Barry Moore, L D Alexander-Lister · 2001 · PubMed
  95. Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
    Stephanie Dauth, Ruxandra F. Sîrbulescu, Silvia Jordans, Maren Rehders, Linda Avena, Julia Oswald, Alexander Lerchl, Paul Säftig, Klaudia Brix · 2011 · BMC Neuroscience
  96. Cyclic Ketone Inhibitors of the Cysteine Protease Cathepsin K
    Robert W. Marquis, Yu Ru, Jin Zeng et al. · 2001 · Journal of Medicinal Chemistry
  97. Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C)
    Chih-Min Kam, Marion G. Götz, Gretchen Koot · 2004 · Archives of Biochemistry and Biophysics
  98. Equistatin, a Protease Inhibitor from the Sea Anemone Actinia equina, Is Composed of Three Structural and Functional Domains
    Borut Štrukelj, Brigita Lenar≷cic̆, Kristina Gruden · 2000 · Biochemical and Biophysical Research Communications
  99. Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase.
    Y Ikeda, T Ikata, T Mishiro, Shunji Nakano, Mitsugu Ikebe, Susumu Yasuoka · 2000 · PubMed
  100. Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases
    Marion G. Götz, Conor R. Caffrey, Elizabeth J. Hansell · 2004 · Bioorganic & Medicinal Chemistry
  101. Substrate/propeptide‐derived endo‐epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors
    Norbert Schaschke, Irmgard Assfalg‐Machleidt, Werner Machleidt · 1998 · FEBS Letters
  102. Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation
    Dejan Caglič, Anja Globisch, Maik Kindermann et al. · 2010 · Bioorganic & Medicinal Chemistry
  103. Imaging Proteolysis by Living Human Glioma Cells
    Mansoureh Sameni, Julie Dosescu, Bonnie F. Sloane · 2001 · Biological Chemistry
  104. Cathepsin B and tumor-associated laminin expression in the progression of colorectal adenoma to carcinoma.
    Ashraf Ali Khan, Murli Krishna, Stephen P. Baker · 1998 · PubMed
  105. E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group
    Norbert Schaschke, Irmgard Assfalg‐Machleidt, Werner Machleidt · 1997 · Bioorganic & Medicinal Chemistry
  106. Development of Activity-Based Probes for Cathepsin X
    Margot G. Paulick, Matthew S. Bogyo · 2011 · ACS Chemical Biology
  107. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft
    Igor Štern, Norbert Schaschke, Luis Moroder · 2004 · Biochemical Journal
  108. Structure and functions of human kininogens
    Raul A. DeLa Cadena, Robert W. Colman · 1991 · Trends in Pharmacological Sciences
  109. Papain-like lysosomal cysteine proteases and their inhibitors: drug discovery targets?
    Dŭsan Turk, Boris Turk, Vito Türk · 2003 · Biochemical Society Symposia
  110. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model
    Uta Schurigt, Lisa Sevenich, Corinne Vannier, Mieczyslaw R. Gajda, Anne Schwinde, Fee Werner, Andreas Stahl, Dominik von Elverfeldt, Anne-Katrin Becker, Matthew S. Bogyo et al. · 2008 · Biological Chemistry
  111. The affinity‐labelling of cathepsin s with peptidyl diazomethyl ketones
    Elliott N. Shaw, Sasank Mohanty, Adrijana Čolič · 1993 · FEBS Letters
  112. How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics
    Maurício G. S. Costa, Paulo Ricardo Batista, Cláudio S. Shida, Charles H. Robert, Paulo M. Bisch, Pedro G. Pascutti · 2010 · BMC Genomics
  113. Determination of Cathepsins B and H in Sera and Synovial Fluids of Patients with Different Joint Diseases
    Dušica Gabrijelčič, Anthony Annan-Prah, Branka Rodič · 1990 · Clinical Chemistry and Laboratory Medicine (CCLM)
  114. Interaction of chicken cystatin with inactivated papains
    Ingemar Björk, Karin Ylinenjärvi · 1989 · Biochemical Journal
  115. Cathepsin K: a cysteine protease with unique kinin-degrading properties
    Emmanuel Godat, Fabien Lecaille, Claire Desmazes, Sophie Duchêne, Enrico Weidauer, Paul Säftig, Dieter Brömme, Christophe Vandier, Gilles Lalmanach · 2004 · Biochemical Journal
  116. Structure-Based Development of Pyridoxal Propionate Derivatives as Specific Inhibitors of Cathepsin K in Vitro and in Vivo
    Nobuhiko Katunuma, Atsushi Matsui, Tomoko Inubushi · 2000 · Biochemical and Biophysical Research Communications
  117. Structure of a Cys25→Ser mutant of human cathepsin S
    J.P. Turkenburg, Marieke B. A. C. Lamers, Andrzej Marek Brzozowski · 2002 · Acta Crystallographica Section D Biological Crystallography
  118. Identification of bovine stefin A, a novel protein inhibitor of cysteine proteinases
    Boris Turk, Anka Ritonja, Ingemar Björk · 1995 · FEBS Letters
  119. Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions
    Maia M. Cherney, Fabien Lecaille, Martin Kienitz · 2010 · Journal of Biological Chemistry
  120. High‐molecular‐weight kininogen binds two molecules of cysteine proteinases with different rate constants
    Boris Turk, Veronika Stoka, Vito Türk · 1996 · FEBS Letters
  121. Kinetics of inhibition of bovine cathepsin S by bovine stefin B
    Boris Turk, Adrijana Čolič, Veronika Stoka · 1994 · FEBS Letters
  122. Recombinant human cathepsin X is a carboxymonopeptidase only: a comparison with cathepsins B and L
    Luciano Puzer, Simone S. Cotrin, Maria Helena S. Cezari · 2005 · Biological Chemistry
  123. Novel Peptidyl Aryl Vinyl Sulfones as Highly Potent and Selective Inhibitors of Cathepsins L and B
    Laura Mendieta, Anna Picó, Teresa Tarragó · 2010 · ChemMedChem
  124. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro‐part domain
    Johan Gotthardt Olsen, Anders Kadziola, Conni Lauritzen · 2001 · FEBS Letters
  125. Serum cathepsin B levels and urinary excretion of cathepsin B in the cancer patients with remote metastasis
    Tetsuya Hirano, Tadao Manabe, Shinji Takeuchi · 1993 · Cancer Letters
  126. Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain‐like endo‐ and exopeptidases
    Marko Mihelič, Cory Teuscher, Vito Türk · 2006 · FEBS Letters
  127. Specificity of human cathepsin S determined by processing of peptide substrates and MHC class II-associated invariant chain
    Thomas Rückrich, Jens Brandenburg, Alexander Cansier et al. · 2006 · Biological Chemistry
  128. The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents
    Herbert Angliker, Peter Wikström, Heidrun Kirschke · 1989 · Biochemical Journal
  129. High-affinity binding of two molecules of cysteine proteinases to low-molecular-weight kininogen
    Boris Turk, Veronika Stoka, Ingemar Björk · 1995 · Protein Science
  130. Lung cysteine cathepsins: Intruders or unorthodox contributors to the kallikrein–kinin system?
    Florian Veillard, Fabien Lecaille, Gilles Lalmanach · 2007 · The International Journal of Biochemistry & Cell Biology
  131. Cathepsin B-Like Activity as a Serum Tumour Marker in Ovarian Carcinoma
    Maria Warwas, H Haczyńska, Jerzy Gerber · 1997 · Clinical Chemistry and Laboratory Medicine (CCLM)
  132. Functional involvement of cathepsin W in the cytotoxic activity of NK‐92 cells
    Thomas Wex, Heike Wex, Roland Hartig · 2003 · FEBS Letters
  133. E64 [trans-epoxysuccinyl- l -leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions
    Barbara J. Gour-Salin, Paule Lachance, Marie‐Claude Magny · 1994 · Biochemical Journal
  134. Nuclear Cathepsin F Regulates Activation Markers in Rat Hepatic Stellate Cells
    Gunter Maubach, Michelle Chin Chia Lim, Lang Zhuo · 2008 · Molecular Biology of the Cell
  135. Localization of DNA sequences governing alternative mRNA production of rat kininogen genes.
    Akira Kakizuka, N Kitamura, Shigetada Nakanishi · 1988 · Journal of Biological Chemistry
  136. Selective Inhibition of the Collagenase Activity of Cathepsin K
    Jana Selent, Jadwiga Kaleta, Zhenqiang Li · 2007 · Journal of Biological Chemistry
  137. Intracellular trafficking of lysosomal proteins and lysosomes
    Andrej Hasilík, Christian Wrocklage, Bernd Schröder · 2009 · International Journal of Clinical Pharmacology and Therapeutics
  138. Biosynthesis of leupeptin.
    Makoto Hori, Hiromichi Hemmi, Kayoko Suzukake · 1978 · The Journal of Antibiotics
  139. Boophilus microplus cathepsin L-like (BmCL1) cysteine protease: Specificity study using a peptide phage display library
    Renan Orsati Clara, Tatiane Sanches Soares, Ricardo J.S. Torquato · 2011 · Veterinary Parasitology
  140. Quantitative Evaluation of Each Catalytic Subsite of Cathepsin B for Inhibitory Activity Based on Inhibitory Activity–Binding Mode Relationship of Epoxysuccinyl Inhibitors by X-ray Crystal Structure Analyses of Complexes
    Daiya Watanabe, Atsushi Yamamoto, Koji Tomoo · 2006 · Journal of Molecular Biology
  141. Cystatin C Deficiency Promotes Epidermal Dysplasia in K14-HPV16 Transgenic Mice
    Weifang Yu, Jian Liu, Michael A. Shi, Jianan Wang, Meixiang Xiang, Shiro Kitamoto, Bing Wang, Galina K. Sukhova, Gëorge F. Murphy, Gabriela Orasanu et al. · 2010 · PLoS ONE
  142. RAT PROCATHEPSIN B
    Mirek Cygler, Jayaraman Sivaraman, Paweł Grochulski · 1996 · Worldwide Protein Data Bank
  143. Imaging Proteolysis by Living Human Glioma Cells
    Mansoureh Sameni, Julie Dosescu, Bonnie F. Sloane · 2001 · Biological Chemistry
  144. Sorting of Non-Glycosylated Human Procathepsin S in Mammalian Cells
    K Nissler, Stefan Kreusch, Winfried Rommerskirch · 1998 · Biological Chemistry
  145. Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.
    Tadeusz Sebzda, Yousif Saleh, Jakub Gburek · 2006 · PubMed
  146. Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide
    Virginie Hervé‐Grépinet, Florian Veillard, Emmanuel Godat, Nathalie Heuzé‐Vourc'h, Fabien Lecaille, Gilles Lalmanach · 2008 · FEBS Letters
  147. Cathepsin X cleavage of the β2 integrin regulates talin-binding and LFA-1 affinity in T cells
    Zala Jevnikar, Nataša Obermajer, Bojan Doljak, Samo Turk, Stanislav Gobec, Urban Švajger, Stephan Hailfinger, Margot Thome, Janko Kos · 2011 · Journal of Leukocyte Biology
  148. Cathepsin X cleaves the β2 cytoplasmic tail of LFA‐1 inducing the intermediate affinity form of LFA‐1 and α‐actinin‐1 binding
    Zala Jevnikar, Nataša Obermajer, Urša Pečar‐Fonović · 2009 · European Journal of Immunology
  149. Modulation of hypotensive effects of kinins by cathepsin K
    Fabien Lecaille, Christophe Vandier, Emmanuel Godat, Virginie Hervé‐Grépinet, Dieter Brömme, Gilles Lalmanach · 2006 · Archives of Biochemistry and Biophysics
  150. A fragment of the major histocompatibility complex class II – associated p41 invariant chain inhibits cruzipain, the major cysteine proteinase from Trypanosoma cruzi
    Tadeja Bevec, Veronika Stoka, Galina Pungerčič · 1997 · FEBS Letters
  151. Conserved cystatin segments as models for designing specific substrates and inhibitors of cysteine proteinases
    Gilles Lalmanach, Carole Serveau, Michéle Brillard‐Bourdet · 1995 · Journal of Protein Chemistry
  152. Drug delivery strategies for cathepsin inhibitors in joint diseases
    Dong Wang, Dieter Brömme · 2005 · Expert Opinion on Drug Delivery
  153. Lysosomal Proteases: Revival of the Sleeping Beauty
    Klaudia Brix · 2013
  154. The Occluding Loop of Cathepsin B Prevents Its Effective Inhibition by Human Kininogens
    Clément Naudin, Fabien Lecaille, S. Chowdhury · 2010 · Journal of Molecular Biology
  155. Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates
    Marcela Oliveira, Ricardo J.S. Torquato, Márcio F.M. Alves · 2010 · Peptides
  156. Potent Inactivation of Cathepsins S and L by Peptidyl (Acyloxy)methyl Ketones
    Dieter Brömme, Roger A. Smith, Peter J. Coles · 1994 · Biological Chemistry Hoppe-Seyler
  157. Correction: Article on Lysosomal Cathepsin B Functions in Podosome
    2008 · Cancer Research
  158. High Molecular Weight Kininogen Activates B2 Receptor Signaling Pathway in Human Vascular Endothelial Cells
    Dhaval Sanjeev Kolte, Noah J. Osman, Jia Yang · 2011 · Journal of Biological Chemistry
  159. Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent
    Jeffrey K. Kerns, Hong Nie, William E. Bondinell et al. · 2011 · Bioorganic & Medicinal Chemistry Letters
  160. Modification of S1 subsite specificity in the cysteine protease cathepsin B
    Ted Fox, Patrizia Mason, Andrew C. Storer · 1995 · Protein Engineering Design and Selection
  161. A structural network associated with the kallikrein-kinin and renin-angiotensin systems
    Veronika Stoka, Vito Türk · 2010 · Biological Chemistry
  162. The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression
    Lydiane Funkelstein, VIVIAN Y. H. HOOK · 2011 · Methods in molecular biology
  163. Serum cysteine proteases and their inhibitors in rheumatoid arthritis: relation to disease activity and radiographic progression
    The DRD and TIRA study groups, Iben Jørgensen, Janko Kos · 2010 · Clinical Rheumatology
  164. The combined action of two enzymes in human serum can mimic the activity of cathepsin B
    John S. Mort, Michèle S. Leduc · 1984 · Clinica Chimica Acta
  165. Resistance of cathepsin L compared to elastase to proteolysis when complexed with the serpin endopin 2C, and recovery of cathepsin L activity
    Shin‐Rong Hwang, Veronika Stoka, Vito Türk · 2006 · Biochemical and Biophysical Research Communications
  166. SERUM CATHEPSIN-B LEVELS AND URINARY-EXCRETION OF CATHEPSIN-B IN THE PATIENTS WITH COLORECTAL-CANCER - POSSIBLE INDICATORS FOR TUMOR MALIGNANCY
    T HIRANO, S TAKEUCHI · 1994 · International Journal of Oncology
  167. Cathepsins S, L, and K and Their Pathophysiological Relevance in Obesity
    Jean-Charles Lafarge, Karine Clément, Michèle Guerre-Millo · 2011 · Clinical Reviews in Bone and Mineral Metabolism
  168. Protein Superfamilies
    Florencio Pazos, Luis Sánchez‐Pulido · 2014 · Encyclopedia of Life Sciences