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Cited by 68Cancer-related Molecular PathwaysCellular transport and secretionHippo pathway signaling and YAP/TAZ

BAR the door: Cancer suppression by amphiphysin-like genes

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Prendergast, George C., Muller, Alexander J., Ramalingam, Arivudanambi, Chang, Mee Young·2009·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
DOI 10.1016/j.bbcan.2008.09.001PMC PMC2874822
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Abstract

The evolutionarily conserved amphiphysin-like genes Bin1 and Bin3 function in membrane and actin dynamics, cell polarity, and stress signaling. Recent genetic studies in mice discriminate non-essential roles in endocytic processes commonly ascribed to amphiphysins from essential roles in cancer suppression. Bin1 acts in default pathways of apoptosis and senescence that are triggered by the Myc and Raf oncogenes in primary cells, and Bin1 gene products display a 'moonlighting function' in the nucleus where a variety of other 'endocytic' proteins are also found. Together, genetic investigations in yeast, flies, and mice suggest that amphiphysin-like adapter proteins may suppress cancer by helping integrate cell polarity signals generated by actin and vesicle dynamics with central regulators of cell cycle arrest, apoptosis, and immune surveillance.

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Crossref · 10.1016/j.bbcan.2008.09.001

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  • BIN1 is broadly expressed in several tissues, with the highest expression in skeletal muscle.

    “Unlike its close paralog Amphiphysin 1, BIN1 is broadly expressed in several tissues, with the highest expression in skeletal muscle [2, 4, 6, 11].”

    From Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts (2016) · cites this paper as [11]

    The Introduction says BIN1 is expressed ubiquitously in mammalian cells, unlike Amphiphysin I, which is primarily restricted to neurons. The section on muscle development describes high BIN1 expression in skeletal muscle, but our copy does not establish that skeletal muscle has the highest expression of any tissue. No page numbers were provided for these passages. (LLM, conf=0.86)

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  1. [1]Ren G Vajjhala P Lee JS Winsor B Munn AL The BAR domain proteins: molding membranes in fission, fusion, and phagy Microbiol Mol Biol Rev 70 2006 37 120 16524918 PMC1393252
  2. [2]Sakamuro D Elliott K Wechsler-Reya R Prendergast GC BIN1 is a novel MYC-interacting protein with features of a tumor suppressor Nature Genet 14 1996 69 77 8782822
  3. [3]Peter BJ Kent HM Mills IG Vallis Y Butler PJ Evans PR McMahon HT BAR domains as sensors of membrane curvature: the amphiphysin BAR structure Science 303 2003 495 499 14645856
  4. [4]Habermann B The BAR domain family of proteins: a case of bending and binding? EMBO Rep 5 2004 250 255 14993925 PMC1299016
  5. [5]Itoh T Erdmann KS Roux A Habermann B Werner H De Camilli P Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins Dev Cell 9 2005 791 804 16326391
  6. [6]Pilecka I Banach-Orlowska M Miaczynska M Nuclear functions of endocytic proteins Eur J Cell Biol 86 2007 533 547 17583371
  7. [7]Wechsler-Reya R Elliott K Herlyn M Prendergast GC The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein whose localization is altered in malignant cells Cancer Res 57 1997 3258 3263 9242458
  8. [8]Elliott K Sakamuro D Basu A Du W Wunner W Staller P Gaubatz S Zhang H Prochownik E Eilers M Prendergast GC Bin1 functionally interacts with Myc in cells and inhibits cell proliferation by multiple mechanisms Oncogene 18 1999 3564 3573 10380878
  9. [9]Miaczynska M Christoforidis S Giner A Shevchenko A Uttenweiler-Joseph S Habermann B Wilm M Parton RG Zerial M APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment Cell 116 2004 445 456 15016378
  10. [10]Casal E Federici L Zhang W Fernandez-Recio J Priego EM Miguel RN DuHadaway JB Prendergast GC Luisi BF Laue ED The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition Biochemistry 45 2006 12917 12928 17059209 PMC2572078
  11. [11]Dawson JC Legg JA Machesky LM Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis Trends Cell Biol 16 2006 493 498 16949824
  12. [12]Itoh T De Camilli P BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature Biochim Biophys Acta 1761 2006 897 912 16938488
  13. [13]Chitu V Stanley ER Pombe Cdc15 homology (PCH) proteins: coordinators of membrane-cytoskeletal interactions Trends Cell Biol 17 2007 145 156 17296299
  14. [15]Tsutsui K Maeda Y Tsutsui K Seki S Tokunaga A cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants Biochem Biophys Res Comm 236 1997 178 183 9223448
  15. [16]Kadlec L Pendergast A-M The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation Proc Natl Acad Sci U S A 94 1997 12390 12395 9356459 PMC24959
  16. [17]Sparks AB Hoffman NG McConnell SJ Fowlkes DM Kay BK Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins Nat Biotech 14 1996 741 744 9630982
  17. [18]Wechsler DS Dang CV Opposite orientations of DNA bending by c-Myc and Max Proc Natl Acad Sci USA 89 1992 7635 7639 1323849 PMC49765
  18. [19]DuHadaway JB Sakamuro D Ewert DL Prendergast GC Bin1 mediates apoptosis by c-Myc in transformed primary cells Cancer Res 16 2001 3151 3156 11306501
  19. [20]Elliott K Ge K Du W Prendergast GC The c-Myc-interacting adapter protein Bin1 activates a caspase-independent cell death program Oncogene 19 2000 4669 4684 11032017
  20. [21]Galderisi U Di Bernardo G Cipollaro M Jori FP Piegari E Cascino A Peluso G Melone MAB Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein J Cell Biochem 74 1999 313 322 10412034
  21. [22]Ge K DuHadaway J Du W Herlyn M Rodeck U Prendergast GC Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma Proc Natl Acad Sci USA 96 1999 9689 9694 10449755 PMC22271
  22. [23]Ge K Minhas F DuHadaway J Mao N-C Wilson D Sakamuro D Buccafusca R Nelson P Malkowicz SB Tomaszewski JT Prendergast GC Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma Int J Cancer 86 2000 155 161 10738240
  23. [24]Ge K DuHadaway J Sakamuro D Wechsler-Reya R Reynolds C Prendergast GC Losses of the tumor suppressor Bin1 in breast carcinoma are frequent and reflect deficits in a programmed cell death capacity Int J Cancer 85 2000 376 383 10652430
  24. [25]Li FQ Coonrod A Horwitz M Selection of a dominant negative retinoblastoma protein (RB) inhibiting satellite myoblast differentiation implies an indirect interaction between MyoD and RB Mol Cell Biol 20 2000 5129 5139 10866669 PMC85962
  25. [26]Pineda-Lucena A Ho CS Mao DY Sheng Y Laister RC Muhandiram R Lu Y Seet BT Katz S Szyperski T Penn LZ Arrowsmith CH A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants J Mol Biol 351 2005 182 194 15992821
  26. [28]Muller AJ DuHadaway JB Donover PS Sutanto-Ward E Prendergast GC Targeted deletion of the suppressor gene Bin1/Amphiphysin2 enhances the malignant character of transformed cells Cancer Biol Ther 3 2004 1236 1242 15611650
  27. [29]Tajiri T Liu X Thompson PM Tanaka S Suita S Zhao H Maris JM Prendergast GC Hogarty MD Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features Clin Cancer Res 9 2003 3345 3355 12960121
  28. [30]Mao NC Steingrimsson E DuHadaway J Wasserman W Ruiz JC Copeland NG Jenkins NA Prendergast GC The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2 Genomics 56 1999 51 58 10036185
  29. [31]Wechsler-Reya R Elliott K Prendergast GC A role for the putative tumor suppressor Bin1 in muscle cell differentiation Mol Cell Biol 18 1998 566 575 9418903 PMC121524
  30. [33]Routhier EL Burn TC Abbaszade I Summers M Albright CF Prendergast GC Human Bin3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p J Biol Chem 276 2001 2167 21677 11274158
  31. [34]Ramalingam A Duhadaway JB Sutanto-Ward E Wang Y Dinchuk J Huang M Donover PS Boulden J McNally LM Soler AP Muller AJ Duncan MK Prendergast GC Bin3 deletion causes cataracts and increased susceptibility to lymphoma during aging Cancer Res 68 2008 1683 1690 18339847
  32. [35]Pierrat B Simonen M Cueto M Mestan J Ferrigno P Heim J SH3GLB, a new endophilin-related protein family featuring an SH3 domain Genomics 71 2001 222 234 11161816
  33. [36]Takahashi Y Karbowski M Yamaguchi H Kazi A Wu J Sebti SM Youle RJ Wang HG Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis Mol Cell Biol 25 2005 9369 9382 16227588 PMC1265816
  34. [37]Karbowski M Jeong SY Youle RJ Endophilin B1 is required for the maintenance of mitochondrial morphology J Cell Biol 166 2004 1027 1039 15452144 PMC2172012
  35. [38]Modregger J Schmidt AA Ritter B Huttner WB Plomann M Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1 J Biol Chem 278 2003 4160 4167 12456676
  36. [39]Mitsuuchi Y Johnson SW Sonoda G Tanno S Golemis EA Testa JR Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2 Oncogene 18 1999 4891 4898 10490823
  37. [40]Yang L Lin HK Altuwaijri S Xie S Wang L Chang C APPL suppresses androgen receptor transactivation via potentiating Akt activity J Biol Chem 278 2003 16820 16827 12621049
  38. [41]Kovacs EM Makar RS Gertler FB Tuba stimulates intracellular N-WASP-dependent actin assembly J Cell Sci 119 2006 2715 2726 16757518
  39. [42]Salazar MA Kwiatkowski AV Pellegrini L Cestra G Butler MH Rossman KL Serna DM Sondek J Gertler FB De Camilli P Tuba: A novel protein containing Bin/Amphiphysin/Rvs (BAR) and Dbl homology domains links dynamin to regulation of the actin cytoskeleton J Biol Chem 2003 14506234
  40. [43]Parks WT Frank DB Huff C Renfrew Haft C Martin J Meng X de Caestecker MP McNally JG Reddi A Taylor SI Roberts AB Wang T Lechleider RJ Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases J Biol Chem 276 2001 19332 19339 11279102
  41. [44]Borkhardt A Bojesen S Haas OA Fuchs U Bartelheimer D Loncarevic IF Bohle RM Harbott J Repp R Jaeger U Viehmann S Henn T Korth P Scharr D Lampert F The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q Proc Natl Acad Sci U S A 97 2000 9168 9173 10908648 PMC16840
  42. [45]Ge K Prendergast GC Bin2, a functionally nonredundant member of the BAR adaptor gene family Genomics 67 2000 210 220 10903846
  43. [46]Antoine JC Absi L Honnorat J Boulesteix JM de Brouker T Vial C Butler M De Camilli P Michel D Antiamphiphysin antibodies are associated with various paraneoplastic neurological syndromes and tumors Arch Neurol 56 1999 172 177 10025422
  44. [47]Hildebrand JD Taylor JM Parsons JT An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase Mol Cell Biol 16 1996 3169 3178 8649427 PMC231310
  45. [48]Siesser PM Hanks SK The signaling and biological implications of FAK overexpression in cancer Clin Cancer Res 12 2006 3233 3237 16740741
  46. [49]Mon NN Ito S Senga T Hamaguchi M FAK signaling in neoplastic disorders: a linkage between inflammation and cancer Ann N Y Acad Sci 1086 2006 199 212 17185517
  47. [50]Ishibashi Y Maita H Yano M Koike N Tamai K Ariga H Iguchi-Ariga SM Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus FEBS Lett 506 2001 33 38 11591366
  48. [51]Chen JL Limnander A Rothman PB Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene Blood 111 2008 1677 1685 18042805
  49. [52]Muller AJ Baker JF DuHadaway JB Ge K Farmer G Donover PS Meade R Reid C Grzanna R Roach AH Shah N Soler AP Prendergast GC Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation Mol Cell Biol 23 2003 4295 4306 12773571 PMC156129
  50. [53]Crouzet M Urdaci M Dulau L Aigle M Yeast mutant affected for viability upon nutrient starvation: characterization and cloning of the RVS161 gene Yeast 7 1991 727 743 1776363
  51. [54]Bauer F Urdaci M Aigle M Crouzet M Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns Mol Cell Biol 13 1993 5070 5084 8336735 PMC360159
  52. [55]Munn AL Stevenson BJ Geli MI Riezman H end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae Mol Biol Cell 6 1995 1721 1742 8590801 PMC301328
  53. [56]Friesen H Colwill K Robertson K Schub O Andrews B Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking Genetics 170 2005 555 568 15802519 PMC1450407
  54. [57]Germann M Swain E Bergman L Nickels JT Jr Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p J Biol Chem 280 2005 4270 4278 15561700
  55. [58]Navarro P Durrens P Aigle M Protein-protein interaction between the RVS161 and RVS167 gene products of Saccharomyces cerevisiae Biochim Biophys Acta 1343 1997 187 192 9434108
  56. [59]Lombardi R Riezman H Rvs161p and Rvs167p, the two yeast amphiphysin homologs, function together in vivo J Biol Chem 276 2001 6016 6022 11096097
  57. [60]Friesen H Humphries C Ho Y Schub O Colwill K Andrews B Characterization of the yeast amphiphysins Rvs161p and Rvs167p reveals roles for the Rvs heterodimer in vivo Mol Biol Cell 17 2006 1306 1321 16394103 PMC1382319
  58. [61]Friesen H Murphy K Breitkreutz A Tyers M Andrews B Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation Mol Biol Cell 14 2003 3027 3040 12857883 PMC165695
  59. [62]Lee J Colwill K Aneuliunas V Tennyson c Moore L Ho Y Andrews B Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton Curr Biol 8 1998 1310 1321 9843683
  60. [63]Floyd SR Porrom EB Slepnev VI Ochoa GC Tsai LH De Camilli P Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2 J Biol Chem 276 2001 8104 8110 11113134
  61. [64]Huang D Patrick G Moffat J Tsai LH Andrews B Mammalian cdk5 is a functional homologue of the budding yeast Pho85 Proc Natl Acad Sci USA 96 1999 14445 14450 10588725 PMC24456
  62. [65]Tan TC Valova VA Malladi CS Graham ME Berven LA Jupp OJ Hansra G McClure SJ Sarcevic B Boadle RA Larsen MR Cousin MA Robinson PJ Cdk5 is essential for synaptic vesicle endocytosis Nat Cell Biol 5 2003 701 710 12855954
  63. [66]Smith DS Tsai LH Cdk5 behind the wheel: a role in trafficking and transport? Trends Cell Biol 12 2002 28 36 11854007
  64. [67]Patrick GN Zukerberg L Nikolic M de la Monte S Dikkes P Tsai LH Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Nature 402 1999 615 622 10604467
  65. [68]Sivadon P Bauer F Aigle M Crouzet M Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin Mol Gen Genet 246 1995 485 495 7891662
  66. [69]Breton AM Aigle M Genetic and functional relationship between Rvsp, myosin and actin in Saccharomyces cerevisiae Curr Genet 34 1998 280 286 9799361
  67. [70]Balguerie A Sivadon P Bonneu M Aigle M Rvs167p, the budding yeast homolog of amphiphysin, colocalizes with actin patches J Cell Sci 112 1999 2529 2537 10393809
  68. [71]Brizzio V Gammie AE Rose MD Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae J Cell Biol 141 1998 567 584 9566960 PMC2132759
  69. [72]Drees BL Sundin B Brazeau E Caviston JP Chen GC Guo W Kozminski KG Lau MW Moskow JJ Tong A Schenkman LR McKenzie Ar Brennwald P Longtine M Bi E Chan C Novick P Boone C Pringle JR Davis TN Fields S Drubin DG A protein interaction map for cell polarity development J Cell Biol 154 2001 549 571 11489916 PMC2196425
  70. [73]Routhier EL Donover PS Prendergast GC hob1+, the homolog of Bin1 in fission yeast, is dispensable for endocytosis but required for the response to starvation or genotoxic stress Oncogene 22 2003 637 648 12569356
  71. [74]Huang A Fuchs D Widner B Glover C Henderson DC Allen-Mersh TG Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer Br J Cancer 86 2002 1691 1696 12087451 PMC2375406
  72. [75]Ramalingam A Prendergast GC Bin1 homolog hob1 supports a rad6-set1 pathway of transcriptional repression in fission yeast Cell Cycle 6 2007 1655 1662 17611416
  73. [77]Knoepfler PS Zhang XY Cheng PF Gafken PR McMahon SB Eisenman RN Myc influences global chromatin structure EMBO J 25 2006 2723 2734 16724113 PMC1500848
  74. [78]Koch HB Zhang R Verdoodt B Bailey A Zhang CD Yates JR 3rd Menssen A Hermeking H Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach Cell Cycle 6 2007 205 217 17314511
  75. [79]Coll PM Rincon SA Izquierdo RA Perez P Hob3p, the fission yast ortholog of human Bin3, localizes Cdc42p to the division site and regulates cytokinesis EMBO J 26 2007 1865 1877 17363901 PMC1847667
  76. [80]Rincon S Coll PM Perez P Spatial regulation of Cdc42 during cytokinesis Cell Cycle 6 2007 1687 1691 17637568
  77. [81]Razzaq A Robinson IM McMahon HT Skepper JN Su Y Zelhof AC Jackson AP Gay NJ O’Kane CJ Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila Genes Dev 15 2001 2967 2979 11711432 PMC312829
  78. [82]Zelhof AC Bao H Hardy RW Razzaq A Zhang B Doe CQ Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis Development 128 2001 5005 5015 11748137
  79. [83]Humbert P Russell S Richardson H Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer Bioessays 25 2003 542 553 12766944
  80. [84]Pagliarini RA Xu T A genetic screen in drosophila for metastatic behavior Science 302 2003 1227 1231 14551319
  81. [85]Chang M Boulden J Sutanto-Ward E Duhadaway JB Soler AP Muller AJ Prendergast GC Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression Cancer Res 67 2007 100 107 17210688
  82. [86]Chang M Boulden J Katz JB Wang L Meyer TJ Soler AP Muller AJ Prendergast GC Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer Cancer Res 67 2007 7605 7612 17699764
  83. [87]Moreno E Basler K dMyc transforms cells into super-competitors Cell 117 2004 117 129 15066287
  84. [88]Kajiho H Saito K Tsujita K Kontani K Araki Y Kurosu H Katada T RIN3 a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway J Cell Sci 116 2003 4159 4168 12972505
  85. [89]Hirst M Ho C Sabourin L Rudnicki M Penn L Sadowski I A two-hybrid system for transactivator bait proteins Proc Natl Acad Sci U S A 98 2001 8726 8731 11447261 PMC37503
  86. [90]EntrezBin1, http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSe arch=274&ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
  87. [91]DuHadaway JB Lynch FJ Brisbay S Bueso-Ramos C Troncoso P McDonnell T Prendergast GC Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: Diverse sites of nuclear expression and losses in prostate cancer J Cell Biochem 88 2003 635 642 12532338
  88. [92]Wechsler-Reya R Sakamuro D Zhang J Duhadaway J Prendergast GC Structural analysis of the human BIN1 gene: evidence for tissue-specific transcriptional regulation and alternate RNA splicing J Biol Chem 272 1997 31453 31458 9395479
  89. [93]Gold ES Morrissette NS Underhill DM Guo J Bassetti M Aderem A Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis Immunity 12 2000 285 292 10755615
  90. [94]Ramjaun AR Micheva KD Bouchelet I McPherson PS Identification and characterization of a nerve terminal-enriched amphiphysin isoform J Biol Chem 272 1997 16700 16706 9195986
  91. [95]Lee E Marcucci M Daniell L Pypaert M Weisz OA Ochoa GC Farsad K Wenk MR De Camilli P Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle Science 297 2002 1193 1196 12183633
  92. [96]Karni R de Stanchina E Lowe SW Sinha R Mu D Krainer AR The gene encoding the splicing factor SF2/ASF is a proto-oncogene Nat Struct Mol Biol 2007 PMC4595851 17310252
  93. [97]Xu Q Lee C Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences Nucleic Acids Res 31 2003 5635 5643 14500827 PMC206480
  94. [98]Roy M Xu Q Lee C Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms Nucleic Acids Res 33 2005 5026 5033 16147986 PMC1201329
  95. [99]Nesbit CE Grove LE Yin X Prochownik EV Differential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins Cell Growth Diff 9 1998 731 741 9751117
  96. [100]Kinney EL Tanida S Rodrigue AA Johnson JK Tompkins VS Sakamuro D Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism J Cell Physiol 2008 18348166
  97. [101]Ghaneie A Zemba-Palko V Itoh H Itoh K Sakamuro D Nakamura S Soler AP Prendergast GC Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival Cancer Biol Ther 6 2007 17218774
  98. [102]Hogarty MD Liu X Thompson PM White PS Sulman EP Maris JM Brodeur GM BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification Med Pediatr Oncol 35 2000 559 562 11107117
  99. [103]Huang H Colella S Kurrer M Yonekawa Y Kleihues P Ohgaki H Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays Cancer Res 60 2000 6868 6874 11156382
  100. [104]Cher ML Bova GS Moore DH Small EJ Carroll PR Pin SS Epstein JI Isaacs WB Jensen RH Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping Cancer Res 56 1996 3091 3102 8674067
  101. [105]DuHadaway JB Du W Liu A-X Baker J Donover PS Sharp DM Muller AJ Prendergast GC Transformation selective apoptosis by farnesyltransferase inhibitors requires Bin1 Oncogene 22 2003 3578 3588 12789266
  102. [106]McCarthy NJ Whyte MKB Gilbert CS Evan GI Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak J Cell Biol 136 1997 215 227 9008715 PMC2132458
  103. [107]Quignon F De Bels F Koken M Feunteun J Ameisen JC de The H PML induces a novel caspase-independent death process Nat Genet 20 1998 259 265 9806544
  104. [108]Wang ZG Ruggero D Ronchetti S Zhong S Gaboli M Rivi R Pandolfi PP PML is essential for multiple apoptotic pathways Nat Genet 20 1998 266 272 9806545
  105. [109]Partanen JI Nieminen AI Makela TP Klefstrom J Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization Proc Natl Acad Sci U S A 104 2007 14694 14699 17766436 PMC1976192
  106. [110]Baas AF Smit L Clevers H LKB1 tumor suppressor protein: PARtaker in cell polarity Trends Cell Biol 14 2004 312 319 15183188
  107. [111]Frisch SM E1a induces the expression of epithelial characteristics J Cell Biol 127 1994 1085 1096 7525602 PMC2200048
  108. [112]Frisch SM The epithelial cell default-phenotype hypothesis and its implications for cancer Bioessays 19 1997 705 709 9264253
  109. [113]Grooteclaes ML Frisch SM Evidence for a function of CtBP in epithelial gene regulation and anoikis Oncogene 19 2000 3823 3828 10949939
  110. [114]Shiio Y Donohoe S Yi EC Goodlett DR Aebersold R Eisenman RN Quantitative proteomic analysis of Myc oncoprotein function EMBO J 21 2002 5088 5096 12356725 PMC129047
  111. [115]Telfer JF Urquhart J Crouch DH Suppression of MEK/ERK signalling by Myc: role of Bin-1 Cell Signal 17 2005 701 708 15722194
  112. [116]Prendergast GC Mechanisms of apoptosis by c-Myc Oncogene 18 1999 2966 2986 10378693
  113. [117]Soucie EL Annis MG Sedivy J Filmus J Leber B Andrews DW Penn LZ Myc potentiates apoptosis by stimulating Bax activity at the mitochondria Mol Cell Biol 21 2001 4725 4736 11416148 PMC87151
  114. [118]Nieminen AI Partanen JI Hau A Klefstrom J c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis EMBO J 26 2007 1055 1067 17268552 PMC1852827
  115. [119]Janicke RU Lee FH Porter AG Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cells Mol Cell Biol 14 1994 5661 5670 8065303 PMC359091
  116. [120]Klefstrom J Arighi E Littlewood T Jaattela M Saksela E Evan GI Alitalo K Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation EMBO J 16 1997 7382 7392 9405367 PMC1170338
  117. [121]Klefstrom J Vastrik I Saksela E Valle J Eilers M Alitalo K c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha EMBO J 13 1994 5442 5450 7957110 PMC395501
  118. [122]Prendergast GC Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects Curr Opin Cell Biol 12 2000 166 173 10712917
  119. [124]Cheng SW Davies KP Yung E Beltran RJ Yu J Kalpana GV c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function Nat Genet 22 1999 102 105 10319872
  120. [125]Novitch BG Mulligan GJ Jacks T Lassar AB Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle J Cell Biol 135 1996 441 456 8896600 PMC2121049
  121. [127]Ramalingam A Duhadaway JB Sutanto-Ward E Wang Y Dinchuk J Huang M Donover PS Boulden J McNally LM Soler AP Muller AJ Duncan MK Prendergast GC Bin3 deletion causes cataracts and elevates the incidence of lymphomas during aging Cancer Res in press 2008 18339847
  122. [128]Di Paolo G Sankaranarayanan S Wenk MR Daniell L Perucco E Caldarone BJ Flavell R Picciotto MR Ryan TA Cremona O De Camilli P Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice Neuron 33 2002 789 804 11879655
  123. [129]Jung M Poepping I Perrot A Ellmer AE Wienker TF Dietz R Reis A Osterziel KJ Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22 Am J Hum Genet 65 1999 1068 1077 10486326 PMC1288240
  124. [130]Owen DJ Wigge P Vallis Y Moore JD Evans PR McMahon HT Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation EMBO J 17 1998 5273 5285 9736607 PMC1170855
  125. [131]Leprince C Le Scolan E Meunier B Fraisier V Brandon N De Gunzburg J Camonis J Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking J Cell Sci 116 2003 1937 1948 12668730
  126. [132]Sinn E Muller W Pattengale P Tepler I Wallace R Leder P Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo Cell 49 1987 465 475 3032456
  127. [133]Lakso M Pichel JG Gorman JR Sauer B Okamoto Y Lee E Alt FW Westphal H Efficient in vivo manipulation of mouse genomic sequences at the zygote stage Proc Natl Acad Sci USA 93 1996 5860 5865 8650183 PMC39152
  128. [134]Wigge P Vallis Y McMahon HT Inhibition of receptor-mediated endoctosis by the amphiphysin SH3 domain Curr Biol 7 1997 554 560 9259551
  129. [135]Anggono V Robinson PJ Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis J Neurochem 102 2007 931 943 17437541
  130. [136]De Camilli P Thomas A Cofiell R Folli F Lichte B Piccolo G Meinck HM Austoni M Fassetta G Bottazzo G The synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer J Exp Med 178 1993 2219 2223 8245793 PMC2191289
  131. [137]Prendergast GC Immune escape as a fundamental trait of cancer: focus on IDO Oncogene 2008 18317452
  132. [138]Rubio-Moscardo F Blesa D Mestre C Siebert R Balasas T Benito A Rosenwald A Climent J Martinez JI Schilhabel M Karran EL Gesk S Esteller M deLeeuw R Staudt LM Fernandez-Luna JL Pinkel D Dyer MJ Martinez-Climent JA Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes Blood 106 2005 3214 3222 16051735
  133. [139]Chang BL Liu W Sun J Dimitrov L Li T Turner AR Zheng SL Isaacs WB Xu J Integration of somatic deletion analysis of prostate cancers and germline linkage analysis of prostate cancer families reveals two small consensus regions for prostate cancer genes at 8p Cancer Res 67 2007 4098 4103 17483320
  134. [140]Ye H Pungpravat N Huang BL Muzio LL Mariggio MA Chen Z Wong DT Zhou X Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma Cancer Genet Cytogenet 176 2007 100 106 17656251 PMC2000851
  135. [143]Munn DH Mellor AL Indoleamine 2,3-dioxygenase and tumor-induced tolerance J Clin Invest 117 2007 1147 1154 17476344 PMC1857253
  136. [144]Muller AJ Prendergast GC Indoleamine 2,3-dioxygenase in immune suppression and cancer Curr Cancer Drug Targets 7 2007 31 40 17305476
  137. [145]Bild AH Turkson J Jove R Cytoplasmic transport of Stat3 by receptor-mediated endocytosis EMBO J 21 2002 3255 3263 12093727 PMC126099
  138. [146]Muller AJ Prendergast GC Marrying immunotherapy with chemotherapy: why say IDO? Cancer Res 65 2005 8065 8068 16166276
  139. [147]Muller AJ Scherle PA Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors Nat Rev Cancer 6 2006 613 625 16862192

Cited by

Sorted by citations

Authors
Prendergast, G. C., Muller, A. J., Ramalingam, A., & Chang, M. Y.
Affiliations
  • Thomas Jefferson University (US)
  • Lankenau Institute for Medical Research (US)
Corresponding author
Prendergast, George C.
ORCID
Venue
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher
Elsevier BV
Published
2009-01
Volume
1795
Issue
1
Pages
25-36
ISSN
0304-419X (ISSN-L)
DOI
10.1016/j.bbcan.2008.09.001
PMC
PMC2874822
OpenAlex
W1975151320
Cited by
68
References
7
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 7 · 2013: 1 · 2012: 6
FWCI
0.59
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA100123, R01CA109542)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
BIN1, tumor suppression, moonlighting proteins, endocytosis, apoptosis, senescence, MYC oncogene, cell polarity, actin dynamics, vesicle dynamics, cell cycle arrest, immune surveillance, adaptor proteins
MeSH terms
Animals, Humans, Microfilament Proteins, Models, Biological, Neoplasms, Nerve Tissue Proteins, Nuclear Proteins, Stress, Physiological, Genes, Tumor Suppressor, Cell Polarity, Tumor Suppressor Proteins, Adaptor Proteins, Signal Transducing

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