Small nucleolar RNA and its potential role in breast cancer – A comprehensive review
Abstract
Small Nucleolar RNAs (snoRNAs) are known for their canonical functions, including ribosome biogenesis and RNA modification. snoRNAs act as endogenous sponges that regulate miRNA expression. Thus, precise snoRNA expression is critical for fine-tuning miRNA expression. snoRNAs processed into miRNA-like sequences play a crucial role in regulating the expression of protein-coding genes similar to that of miRNAs. Recent studies have linked snoRNA deregulation to breast cancer (BC). Inappropriate snoRNA expression contributes to BC pathology by facilitating breast cells to acquire cancer hallmarks. Since snoRNAs show significant differential expression in normal and cancer conditions, measuring snoRNA levels could be useful for BC prognosis and diagnosis. The present article provides a comprehensive overview of the role of snoRNAs in breast cancer pathology. More specifically, we have discussed the regulation, biological function, signaling pathways, and clinical utility of abnormally expressed snoRNAs in BC. Besides, we have also discussed the role of snoRNA host genes in breast tumorigenesis and emerging and future research directions in the field of snoRNA and cancer.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Members of SNORD113 and SNORD114 clusters identified as differentially enriched are relatively highly expressed in liver, breast, ovary and prostate.
“the members of SNORD113 and SNORD114 clusters identified differentially enriched in our study are relatively highly expressed in liver, breast, ovary and prostate (Dsouza et al., 2021).”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Dsouza et al., 2021
Cites
Biogenesis of small nucleolar ribonucleoproteins
Filipowicz, W., & Pogačić, V. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00334-4 · Cited by 394 · see citing works
Vulliamy, T., Beswick, R., Kirwan, M., Marrone, A., Digweed, M., Walne, A., & Dokal, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800042105 · Cited by 334 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Fitz, N. F., Wang, J., Kamboh, M. I., Koldamova, R., & Lefterov, I. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105481 · Cited by 49 · see citing works
“According to the sequencing data available in snoDB the members of SNORD113 and SNORD114 clusters identified differentially enriched in our study are relatively highly expressed in liver, breast, ovary and prostate (Dsouza et al., 2021).”
- Authors
- Dsouza, V. L., Adiga, D., Sriharikrishnaa, S., Suresh, P. S., Chatterjee, A., & Kabekkodu, S. P.
- Affiliations
- Manipal Academy of Higher Education (IN)
- National Institute of Technology Calicut (IN)
- University of Otago (NZ)
- Corresponding author
- Kabekkodu, Shama Prasada
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 1875
- Issue
- 1
- Pages
- 188501
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W3120645441
- Cited by
- 48
- References
- 2
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 12 · 2021: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society Te Apārangi
- Department of Science and Technology, Ministry of Science and Technology, India (EMR/2016/002314, ID-2019/4115/CMB/BMS)
- University of Otago
- Science and Engineering Research Board
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- small nucleolar RNA, breast cancer, microRNA sponge, miRNA expression regulation, ribosome biogenesis, RNA modification, cancer hallmarks, cancer prognosis, tumor diagnosis, signaling pathways, breast tumorigenesis
- MeSH terms
- Breast Neoplasms, Female, Humans, Prognosis, Ribosomes, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, RNA, Small Nucleolar, MicroRNAs, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
